Computational Mechanics

, Volume 46, Issue 1, pp 3–16 | Cite as

A fully-coupled fluid-structure interaction simulation of cerebral aneurysms

  • Y. Bazilevs
  • M.-C. Hsu
  • Y. Zhang
  • W. Wang
  • X. Liang
  • T. Kvamsdal
  • R. Brekken
  • J. G. Isaksen
Open Access
Original Paper


This paper presents a computational vascular fluid-structure interaction (FSI) methodology and its application to patient-specific aneurysm models of the middle cerebral artery bifurcation. A fully coupled fluid-structural simulation approach is reviewed, and main aspects of mesh generation in support of patient-specific vascular FSI analyses are presented. Quantities of hemodynamic interest such as wall shear stress and wall tension are studied to examine the relevance of FSI modeling as compared to the rigid arterial wall assumption. We demonstrate the importance of including the flexible wall modeling in vascular blood flow simulations by performing a comparison study that involves four patient-specific models of cerebral aneurysms varying in shape and size.


Cerebral aneurysms Fluid-structure interaction Arterial wall tissue modeling Incompressible Navier–Stokes equations Boundary layer meshing Wall shear stress Wall tension 


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Copyright information

© The Author(s) 2009

Authors and Affiliations

  • Y. Bazilevs
    • 1
  • M.-C. Hsu
    • 1
  • Y. Zhang
    • 2
  • W. Wang
    • 2
  • X. Liang
    • 2
  • T. Kvamsdal
    • 3
  • R. Brekken
    • 4
  • J. G. Isaksen
    • 5
    • 6
  1. 1.Department of Structural EngineeringUniversity of California, San DiegoLa JollaUSA
  2. 2.Department of Mechanical EngineeringCarnegie Mellon UniversityPittsburghUSA
  3. 3.Department of Applied MathematicsSINTEF Information and Communication TechnologyTrondheimNorway
  4. 4.Department of Medical TechnologySINTEF Health ResearchTrondheimNorway
  5. 5.Departments of Neurosurgery and NeurologyUniversity Hospital of North NorwayTromsøNorway
  6. 6.Institute of Clinical MedicineUniversity of TromsøTromsøNorway

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