Surgical Endoscopy

, Volume 15, Issue 9, pp 1030–1033

Preincisional intravenous low-dose ketamine and local infiltration with ropivacaine reduces postoperative pain after laparoscopic cholecystectomy

  • B. Papaziogas
  • H. Argiriadou
  • P. Papagiannopoulou
  • T. Pavlidis
  • M. Georgiou
  • E. Sfyra
  • T. Papaziogas
Original Articles

DOI: 10.1007/s004640090124

Cite this article as:
Papaziogas, B., Argiriadou, H., Papagiannopoulou, P. et al. Surg Endosc (2001) 15: 1030. doi:10.1007/s004640090124

Abstract

Background

The preincisional use of ketamine combined with local tissue infiltration with Ropivacaine may reduce noxious input during surgery. The goal of this study was to examine whether this combination improves postoperative pain control after laparoscopic cholecystectomy.

Methods

A total of 55 patients were randomly assigned to one of three groups. Group 1 received placebos preincisional. Group 2 received preincisional saline IV and local infiltration with 20 ml ropivacaine (10 mg/ml). Group 3 received preincisional ketamine 1 mg/kg IV and local infiltration with 20 ml ropivacaine (10 mg/ml). Postoperative pain was rated at 0, 3, 6, 12, 24, and 48 h postoperatively by visual analogue scale scores (VAS). Cumulative analgesic consumption and time until first analgesic medication request were recorded.

Results

Group 3 experienced significantly (p<0.05) less pain than group 2 at 6 h and 12 h postoperatively. Groups 2 and 3 did not differ significantly by VAS at 0 h, 3 h, 24 h, and 48 h. Group 1 had significantly higher VAS scores than groups 2 and 3 at 0 h, 3 h, 6 h, 12 h, and 24 h postoperatively. The consumption of analgesics was significantly higher in group 1 than in groups 2 and 3. Although the consumption of analgesics was higher in group 3 than in group 2, this difference did not reach statistical significance. The time to first request for analgesics was significantly longer in groups 2 and 3 than in group 1, with no statistical difference between groups 2 and 3.

Conclusion

Preincisional treatment with low-dose IV ketamine and local infiltration with ropivacaine 1% reduces postoperative pain after laparoscopic cholecystectomy.

Key words

Preemptive pain therapy Ketamine Ropivacaine Laparoscopic cholecystectomy Cholecystectomy Pain control 

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Copyright information

© Springer-Verlag 2001

Authors and Affiliations

  • B. Papaziogas
    • 1
  • H. Argiriadou
    • 2
  • P. Papagiannopoulou
    • 2
  • T. Pavlidis
    • 1
  • M. Georgiou
    • 2
  • E. Sfyra
    • 2
  • T. Papaziogas
    • 1
  1. 1.Department of Surgery“G. Gennimatas” University HospitalThessalonikiGreece
  2. 2.Department of Anesthesiology“G. Gennimatas” University HospitalThessalonikiGreece

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