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Surgical Endoscopy

, Volume 14, Issue 5, pp 452–455 | Cite as

Fluorescence diagnosis of endometriosis using 5-aminolevulinic acid

  • E. Malik
  • C. Berg
  • A. Meyhöfer-Malik
  • O. Buchweitz
  • P. Moubayed
  • K. Diedrich
Article

Abstract

Background: The diagnosis of nonpigmented endometrial lesions by simple laparoscopic visualization is difficult and often inaccurate. We therefore sought to establish a new and more accurate method to visualize these nonpigmented peritoneal changes caused by endometriosis.

Methods: A total of 37 patients received 30 mg 5-aminolevulinic acid/kg body weight 10 to 14 hs prior to surgery. Laparoscopy was then performed using a D-light system (Storz, Tuttlingen, Germany). The findings were evaluated first in the white-light mode; the D-light system was then activated, and all areas of fluorescence were documented. Multiple specimens were obtained by biopsy.

Results: The sensitivity of the fluorescence diagnosis in detecting endometriosis in nonpigmented areas and normal-looking peritoneum is 100%, with a specificity of 75%. Diagnosis by simple visualization under white illumination has a sensitivity of only 69% and a specificity of 70%. Occult areas of endometriosis were discovered using fluorescence diagnosis.

Conclusions: Our findings suggest that fluorescence diagnosis using 5-aminolevulinic acid is feasible and can improve the diagnosis of endometriosis in nonpigmented and occult endometrial lesions. Fluorescence diagnosis is a promising new tool in the diagnosis of endometriosis.

Key words: Fluorescence diagnosis — Endometriosis — 5-aminolevulinic acid — Fluorescence — Photodynamic diagnosis 

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Copyright information

© Springer-Verlag New York Inc. 2000

Authors and Affiliations

  • E. Malik
    • 1
  • C. Berg
    • 1
  • A. Meyhöfer-Malik
    • 1
  • O. Buchweitz
    • 1
  • P. Moubayed
    • 2
  • K. Diedrich
    • 1
  1. 1.Department of Obstetrics and Gynecology, Medical University Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, GermanyDE
  2. 2.Institute of Pathology, Medical University of Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, GermanyDE

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