Over-the-scope-clip applications for perforated peptic ulcer
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To investigate the effectiveness of over-the-scope-clip (OTSC)-based endoscopic closure in patients with perforated peptic ulcer (PPU).
One hundred six patients diagnosed with PPU were treated with either OTSC (n = 26) or conservative treatments (n = 80), respectively. The outcome assessments included technical success rate, clinical success rate, post-treatment complications after 1 month, mortality rate, time to resume oral feeding, length of hospital stay, and the administration of antibiotics.
In the OTSC group, technical and clinical success was achieved in 100% of patients without any complications, including death, incomplete closure, duodenal obstruction, and gastrointestinal bleeding, with a median operation time of 10 min. All patients in the OTSC group were discharged, while the mortality rate in the control group was 13.8%. Subsequent surgeries were required in 30% of patients in the control group. The median times to resume oral feeding were 3.5 (interquartile range [IQR] 2.0–5.25) days in the OTSC group and 7.0 (IQR 5.0–9.0) days in the control group (p < 0.001). One month post-procedure, 30% (24/80) of patients in the control group and 0 (0/26) in the OTSC group required additional operations (p < 0.001). No significant difference was found in the length of the hospital stay and the administration of antibiotics between the two groups (p > 0.05).
OTSC-based endoscopic technique, with a high clinical success rate and a shorter time to resume oral feeding, was effective in achieving closure of PPU with a diameter < 15 mm.
KeywordsOver-the-scope system Perforated peptic ulcer Endoscopic closure Oral feeding
Compliance with ethical standards
Dr. Jing-Jing Wei, Xue-Ping Xie, Ting-Ting Lian, Zhi-Yong Yang, Yu-Feng Pan, Zhen-Lv Lin, Guang-Wei Zheng, and Ze-Hao Zhuang have no conflicts of interest or financial ties to disclose.