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Surgical Endoscopy

, Volume 33, Issue 4, pp 1235–1243 | Cite as

Sentinel node navigation surgery using near-infrared indocyanine green fluorescence in early gastric cancer

  • Dong-Wook Kim
  • Bosu Jeong
  • Il-hyung Shin
  • Uk Kang
  • Yoontaek Lee
  • Young Suk Park
  • Sang-Hoon AhnEmail author
  • Do Joong Park
  • Hyung-Ho Kim
Article

Abstract

Background

The aim of this study was to evaluate the feasibility of indocyanine green (ICG) fluorescent method for sentinel lymph node detection in early gastric cancer.

Methods

Between December 2012 and December 2014, 28 cases of pilot examination were performed at Seoul National University Bundang Hospital. Advanced version of multispectral fluorescence organoscope was used to identify sentinel node by quantitative estimation of ICG fluorescent signal intensity. Sensitivity, specificity, false positive value were analyzed and compared with dual tracer method.

Results

A total of 443 lymph nodes in 28 cases were examined and 184 sentinel nodes (41.5%) were identified by dual tracer method. The sensitivity using near-infrared ICG method was 98.9%. The specificity was 76.0% and false positive rate was 25.4% compared with dual tracer method. The adequate threshold for sentinel node detection was considered as 10% of maximum signal intensity.

Conclusion

New near-infrared ICG fluorescent method could be a promising protocol for sentinel node navigation surgery in early gastric cancer.

Keywords

Sentinel node navigation surgery Early gastric cancer ICG fluorescent signal intensity 

Notes

Acknowledgements

This work was funded by the Seoul Metropolitan Government, Korea, under Contract of R & BD Program WR100001.

Compliance with ethical standards

Disclosure

Dong-Wook Kim, Bosu Jeong, Il-hyung Shin, Uk Kang, Yoontaek Lee, Young Suk Park, Sang-Hoon Ahn, Do Joong Park, and Hyung-Ho Kim have no conflicts of interest or financial ties to disclose.

Ethical approval

The study was approved by Institutional Review Board of Seoul National University Bundang Hospital (registration number: E-1208/167007). The patients were fully informed of the study and filled out a written informed consent. This study was conducted according to the principles of the Declaration of Helsinki.

Supplementary material

Supplementary material 1 (MP4 189198 KB)

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of SurgerySeoul National University Bundang HospitalSeongnamRepublic of Korea
  2. 2.Department of SurgerySeoul National University College of MedicineSeoulRepublic of Korea
  3. 3.Advanced Medical Device Research DivisionKorea Electrotechnology Research InstituteSeoulRepublic of Korea
  4. 4.Biomedical Research InstituteSeoul National University HospitalSeoulRepublic of Korea

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