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Surgical Endoscopy

, Volume 33, Issue 1, pp 206–215 | Cite as

Perioperative and long-term outcomes of laparoscopic versus open liver resection for hepatocellular carcinoma with well-preserved liver function and cirrhotic background: a propensity score matching study

  • Xinqiang Wu
  • Zejian Huang
  • Wan Yee Lau
  • Wenda Li
  • Pai Lin
  • Lei ZhangEmail author
  • Yajin ChenEmail author
Article

Abstract

Background

Although laparoscopic liver resection (LLR) has advanced into a safe and effective alternative to conventional open liver resection (OLR), it has not been widely accepted by surgeons. This article aimed to investigate the perioperative and long-term benefits of LLR versus OLR for hepatocellular carcinoma (HCC) in selected patients with well-preserved liver function and cirrhotic background.

Methods

A retrospective study was conducted on 1085 patients with HCC who underwent liver resection at Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University from July 2010 to July 2015, and 346 patients with well-preserved liver function and cirrhotic background were selected. A 1:1 propensity score matching (PSM), which is the best option to overcome selection bias, was conducted to compare the surgical outcomes and long-term prognosis between LLR and OLR. After PSM, a logistic regression analysis was used to identify the predictive risk factors of posthepatectomy liver failure (PHLF).

Results

By using PSM, the two groups were well balanced with 86 patients in each group. In the LLR group, only the median operation time was significantly longer than the OLR group, but the hospital stay, overall morbidity, and the incidence of PHLF were significantly decreased compared to OLR. There were no significant differences in the overall survival and disease-free survival rates between the two groups. On multivariate analysis, OLR was identified to be the only independent risk factor for PHLF.

Conclusions

In selected HCC patients with well-preserved liver function and cirrhotic background, LLR could be a better option compared to OLR.

Keywords

Laparoscopic liver resection Hepatocellular carcinoma Cirrhosis Long-term outcomes Propensity score matching Multivariate analysis 

Notes

Acknowledgements

We really appreciate Wan Yee Lau, the former chairman of IHBPA, for his useful guidance and suggestion. This work was supported by the National Natural Science Foundation of China (Grant No. 81372562).

Compliance with ethical standards

Diclosures

Drs. Xinqiang Wu, Lei Zhang, Zejian Huang, Won Yee Lau, Wenda Li, Pai Lin, and Yajin Chen have no conflicts of interest or financial ties to disclose.

Supplementary material

464_2018_6296_MOESM1_ESM.doc (220 kb)
Supplementary material 1 (DOC 219 KB)

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Hepato-biliary Surgery, Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouPeople’s Republic of China
  2. 2.Faculty of Medicine, The Chinese University of Hong KongPrince of Wales HospitalHong Kong SARPeople’s Republic of China

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