Gastric per-oral endoscopic myotomy for refractory gastroparesis: a detailed description of the procedure, our experience, and review of the literature
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Background and Aims
Gastric per-oral endoscopic myotomy (G-POEM) was introduced four years ago as an investigational procedure for refractory gastroparesis. The safety and efficacy were currently evaluated. With our recent studies on G-POEM, we share our experience and knowledge through the discussion of a detailed description of the procedure and review of the literature. To our knowledge, this is the first systemic review on this new therapeutic endoscopic procedure.
The indications and contraindications, various aspects of the procedure, and efficacy assessment are discussed based on our experience and current available data.
Preoperative preparation, detailed description of the procedure, post-procedural care, and results in the literature are presented. The procedure is safe and effective. 70–80% of patients have significant improvement in overall symptoms and quality of life in short-term (6 months) follow-up, as assessed by Gastric Cardinal Symptom Index and Short Form 36.
G-POEM is a feasible and effective procedure for refractory gastroparesis based on early and limited data. Well-designed prospective studies are expected to advance and evaluate this new procedure in the future.
KeywordsGastroparesis G-POEM Per-oral pyloromyotomy
LL, wrote the first draft and revised of the manuscript; RS, CQ, YY, SL, HC, HX revised the manuscript; QC designed the study, performed the procedures, provided all the figures, and revised the manuscript.
Compliance with ethical standards
Drs Lianyong Li, Robert Spandorfer, Changmin Qu, Yongtao Yang, Shuwen Liang, Huimin Chen, Hanbing Xue, and Qiang Cai have no conflicts of interest or financial ties to disclose.
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