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Surgical Endoscopy

, Volume 32, Issue 8, pp 3467–3473 | Cite as

Intracorporeal versus extracorporeal anastomosis after laparoscopic left colectomy for splenic flexure cancer: results from a multi-institutional audit on 181 consecutive patients

  • Marco Milone
  • Pierluigi Angelini
  • Giovanna Berardi
  • Morena Burati
  • Francesco Corcione
  • Paolo Delrio
  • Ugo Elmore
  • Maria Lemma
  • Michele Manigrasso
  • Alfredo Mellano
  • Andrea Muratore
  • Ugo Pace
  • Daniela Rega
  • Riccardo Rosati
  • Ernesto Tartaglia
  • Giovanni Domenico De Palma
Article

Abstract

Although intracorporeal anastomosis has been demonstrated to be safe and effective after right colectomy, limited data are available about its efficacy after left colectomy for colon cancer located in splenic flexure. A multi-institutional audit was designed, including 92 patients who underwent laparoscopic left colectomy with intracorporeal anastomosis (IA) compared with 89 matched patients who underwent a laparoscopic left colectomy with extracorporeal anastomosis (EA). There was no significant difference in terms of age, sex, BMI, and ASA score between the two groups. Post-surgical history and stage of disease according to AJCC/UICC TNM were also similar. IA and EA groups demonstrated similar oncologic radicality in terms of the number of lymph nodes harvested (18.5 ± 9 vs. 17.5 ± 8.4; p = 0.48). Recovery after surgery was also better in patients who underwent IA, as confirmed by the shorter time to flatus in the IA group (2.6 ± 1.1 days vs. 3.4 ± 1.2 days; p < 0.001) and higher post-operative pain expressed in the mean VAS Scale in the EA group (1.7 ± 2.1 vs. 3.5 ± 1.6; p < 0.001). Laparoscopic left colectomy with intracorporeal anastomosis was associated with a lower rate of post-operative complications (OR 6.7, 95% CI 2.2–20; p = 0.001). However, when stratifying according to Clavien classification, the difference was consistently confirmed for less severe (class I and II) complications (OR 7.6, 95% CI 2.5–23, p = 0.001) but not for class III, IV, and V complications (OR 1.8, 95% CI 0.1–16.9; p = 0.59). Our results were consistent to hypothesize that a complete laparoscopic approach could be considered a safe method to perform laparoscopic left colectomy with the advantage of a guaranteed faster recovery after surgery. Further randomized clinical trials are needed to obtain a more definitive conclusion.

Keywords

Colorectal Splenic flexure Intracorporeal anastomosis Totally laparoscopic 

Notes

Author contributions

Milone M—conception, design, interpretation of the data and drafting of the article; Milone M, Elmore U, Angelini P, Mellano A, Pace U, Rega D, Tartaglia E, Lemma M, Berardi G, Burati M, Manigrasso M—acquisition, analysis and interpretation of the data; Muratore A, Rosati R, Delrio P, Corcione F, De Palma GD—interpretation of the data and critical revisions; De Palma GD—critical revisions and final approval.

Funding

Marco Milone, Pierluigi Angelini, Berardi G, Morena Burati, Francesco Corcione, Paolo Delrio, Ugo Elmore, Maria Lemma, Alfredo Mellano, Andrea Muratore, Ugo Pace, Daniela Rega, Riccardo Rosati, Ernesto Tartaglia, and Giovanni Domenico De Palma have no financial support to declare or financial ties to disclose.

Compliance with ethical standards

Disclosures

Marco Milone, Pierluigi Angelini, Berardi G, Morena Burati, Francesco Corcione, Paolo Delrio, Ugo Elmore, Maria Lemma, Alfredo Mellano, Andrea Muratore, Ugo Pace, Daniela Rega, Riccardo Rosati, Ernesto Tartaglia, and Giovanni Domenico De Palma have no conflict of interest to declare.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Marco Milone
    • 1
    • 6
  • Pierluigi Angelini
    • 2
  • Giovanna Berardi
    • 1
  • Morena Burati
    • 1
  • Francesco Corcione
    • 2
  • Paolo Delrio
    • 3
  • Ugo Elmore
    • 4
  • Maria Lemma
    • 4
  • Michele Manigrasso
    • 1
  • Alfredo Mellano
    • 5
  • Andrea Muratore
    • 5
  • Ugo Pace
    • 3
  • Daniela Rega
    • 3
  • Riccardo Rosati
    • 4
  • Ernesto Tartaglia
    • 2
  • Giovanni Domenico De Palma
    • 1
  1. 1.University of Naples “Federico II”NapoliItaly
  2. 2.Monaldi HospitalNapoliItaly
  3. 3.Fondazione Giovanni Pascale Cancer Institute, IRCCSNapoliItaly
  4. 4.San Raffaele Scientific Institute, Vita e salute UniversityMilanItaly
  5. 5.Candiolo Cancer Institute, IRCCSCandioloItaly
  6. 6.Department of Clinical Medicine and SurgeryUniversity of Naples “Federico II”NapoliItaly

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