Surgical Endoscopy

, Volume 31, Issue 11, pp 4419–4424 | Cite as

Predictive factors for lymph node metastasis in early gastric cancer with lymphatic invasion after endoscopic resection

  • Ji Won Park
  • Sangjeong Ahn
  • Hyuk Lee
  • Byung-Hoon Min
  • Jun Haeng Lee
  • Poong-Lyul Rhee
  • Kyoung-Mee Kim
  • Jae J. KimEmail author



Lymph node (LN) metastasis is found in only about 5–10% of the patients who undergo additional surgery after non-curative endoscopic resection. Lymphatic invasion after endoscopic submucosal dissection (ESD) is regarded as non-curative resection due to risk of reginal LN metastasis. This study was aimed to identify clinicopathologic predictive factors for LN metastasis in early gastric cancer (EGC) with lymphatic invasion after endoscopic resection.


Among a total of 2036 patients who underwent endoscopic resection for EGC at Samsung Medical Center from April 2000 to May 2011, 146 patients were diagnosed with lymphatic invasion. And 123 patients who had gastrectomy with LN dissection due to presence of lymphatic invasion as one of the non-curative factors were included in this study. Demographics, endoscopic tumor findings, histological findings, surgical findings with pathologic reports, and follow-up data were collected from the patient’s medical records. Pathological re-evaluation of resected specimens was performed.


Among a total of 123 patients, LN metastases were found in seven patients (5.7%). The univariate analysis revealed that the LN metastasis was significantly more frequent in patients with certain morphology of lymphatic invasion that shows adhesion to endothelium of lymphatic tumor emboli (p = 0.016), higher number of lymphatic tumor emboli in whole section (p < 0.001) and papillary adenocarcinoma component (p = 0.024). In multivariate analysis, the number of lymphatic tumor emboli [OR 93.5, 95% CI (2.62–3330.81)] and the presence of papillary adenocarcinoma component [OR 552.5, 95% CI (1.20–254871.81)] were identified as independent predictors of LN metastasis in patients with lymphatic invasion after endoscopic resection.


The number of lymphatic tumor emboli and the presence of papillary adenocarcinoma component were significant predictors for LN metastasis in patients with lymphatic invasion after endoscopic resection.


Lymph node metastasis Early gastric cancer Lymphatic invasion Endoscopic resection 


Compliance with ethical standards


Drs Ji Won Park, Sangjeong Ahn, Hyuk Lee, Byung-Hoon Min, MD, Jun Haeng Lee, Poong-Lyul Rhee, Kyoung-Mee Kim, and Jae J. Kim have no conflicts of interest or financial ties to disclose.


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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • Ji Won Park
    • 1
  • Sangjeong Ahn
    • 2
  • Hyuk Lee
    • 1
  • Byung-Hoon Min
    • 1
  • Jun Haeng Lee
    • 1
  • Poong-Lyul Rhee
    • 1
  • Kyoung-Mee Kim
    • 2
  • Jae J. Kim
    • 1
    Email author
  1. 1.Department of Medicine, Samsung Medical CenterSungkyunkwan University School of MedicineSeoulSouth Korea
  2. 2.Department of Pathology, Samsung Medical CenterSungkyunkwan University School of MedicineSeoulSouth Korea

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