Surgical Endoscopy

, Volume 31, Issue 4, pp 1550–1557 | Cite as

Outcomes in patients with over 1-year follow-up after peroral endoscopic myotomy (POEM)

  • Marc A. WardEmail author
  • Matt Gitelis
  • Lava Patel
  • Yalini Vigneswaran
  • Joann Carbray
  • Michael B. Ujiki



Peroral endoscopic myotomy (POEM) is a promising therapy in the treatment of achalasia. The study was designed to report outcomes, including quality of life, in patients with at least 1-year follow-up.


Patients from an institutional review board-approved protocol underwent POEM and were followed prospectively. Health-related quality of life was measured preoperatively and 1 year post-operatively using Short Form-36 Health Survey version 2 (SF-36v2). Comparisons were made with patients from a prospective database who underwent laparoscopic Heller myotomy (LHM) over the same period. Paired t tests were used to analyze all normally distributed data, while Wilcoxon signed-rank tests were used to analyze SF-36 data, as it does not follow a normal distribution.


We analyzed 41 consecutive POEM patients with at least 1-year follow-up. Significant improvements in quality of life between baseline and 1 year were found in role limitations due to physical health (81.8 ± 25.8 vs. 65.9 ± 31.6, p = 0.01) and social functioning (83 ± 19.1 vs. 64.6 ± 31.3, p = 0.01). When compared to 24 patients who underwent LHM, there was no difference in average Eckardt scores (0.9 ± 1.6 vs. 1.0 ± 1.3, p > 0.05) or incidence of PPI use (43.5 vs. 47.5 %, p = 0.71). However, when looking at just type III patients, POEM patients had a higher remission rate (100 vs. 62.5 %) and significantly lower post-operative Eckardt scores at 1 year (1.1 vs. 3.1, p < 0.05). The average myotomy length of type III achalasia patients undergoing POEM was 18.6 cm (±6.9) compared to 10.3 cm (±1.0) in LHM patients (p < 0.01), which may have contributed to this difference.


POEM provides a significant quality of life benefit at 1 year while having similar relief of dysphagia and post-operative PPI use compared to LHM. Type III achalasia patients may have better outcomes with POEM compared to LHM.


Achalasia Peroral endoscopic myotomy (POEM) Eckardt score Type III achalasia Laparoscopic Heller myotomy 



There are no funding sources to disclose in relation to this project.

Compliance with ethical standards


Dr. Ward, Mr. Gitelis, Dr. Patel, Dr. Vigneswaran, Mrs. Carbray, and Dr. Ujiki have no conflicts of interest or financial ties to disclose.


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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Marc A. Ward
    • 1
    Email author
  • Matt Gitelis
    • 2
  • Lava Patel
    • 2
  • Yalini Vigneswaran
    • 1
  • Joann Carbray
    • 2
  • Michael B. Ujiki
    • 1
    • 2
  1. 1.Department of SurgeryUniversity of ChicagoChicagoUSA
  2. 2.Department of SurgeryNorthShore University HealthSystemEvanstonUSA

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