Surgical Endoscopy

, Volume 31, Issue 1, pp 462–468 | Cite as

Application of clip traction in endoscopic submucosal dissection to the treatment of early esophageal carcinoma and precancerous lesions

  • Xia Xie
  • Jian-Ying Bai
  • Chao-Qiang Fan
  • Xin Yang
  • Xiao-Yan Zhao
  • Hui Dong
  • Shi-Ming YangEmail author
  • Jing YuEmail author
Dynamic Manuscript


Background and aim

It is usually difficult to obtain a good view of the dissection plane during esophageal endoscopic submucosal dissection (ESD). Therefore, the aim of this study was to investigate the efficacy and safety of clip traction in ESD for the treatment of early esophageal carcinoma (EEC) or precancerous lesions.


This is a case-matched comparative study. We selected 100 EEC patients who had undergone ESD. Fifty cases underwent ESD without clip traction (non-clip group), and 50 cases underwent ESD with clip traction (clip group). The patient-related variables, dissection time, data regarding muscularis propria injury, etc. were statistically analyzed.


ESD was successful in all cases without complication. There were no significant differences between the two groups with respect to age, gender, the longitudinal diameter of the lesions, etc. Wide visual field exposure of the submucosal tissue below the lesion was obtained by applying clip traction. The dissection time of ESD was shorter in the clip group than in the non-clip group [22.02 (6.77) min vs 26.48 (12.56); P = 0.018] when the extent of lesion was less than half of the circumference of the esophagus; otherwise, there was no difference between the two groups (P = 0.252). Moreover, the muscularis propria injuries in the clip group were obviously less than the non-clip group (10 vs 30 %, P = 0.007).


Clip traction can decrease the rate of muscularis propria injury and shorten the dissection time. It is recommended as a safe and effective auxiliary procedure for the treatment of esophageal ESD.


Early esophageal carcinoma Endoscopic submucosal dissection Clip Submucosa 1 High-grade intraepithelial neoplasia Low-grade intraepithelial neoplasia 



This work was supported by the Science Foundation of Xinqiao Hospital, Third Military Medical University (No. 2014LCXJS 014).

Compliance with ethical standards


Xia Xie, Jian-Ying Bai, Chao-Qiang Fan, Xin Yang, Xiao-Yan Zhao, Hui Dong, Shi-Ming Yang, and Jing Yu declare that they have no conflicts of interest or financial ties to disclose.

Supplementary material

Supplementary material 1 (AVI 19348 kb)


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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  1. 1.Department of Gastroenterology, Xinqiao HospitalThird Military Medical UniversityChongqingPeople’s Republic of China

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