Surgical Endoscopy

, Volume 30, Issue 9, pp 3987–3993 | Cite as

Diagnostic group classifications of gastric neoplasms by endoscopic resection criteria before and after treatment: real-world experience

  • Jun Hee Lee
  • Yang Won Min
  • Jun Haeng LeeEmail author
  • Eun Ran Kim
  • Hyuk Lee
  • Byung-Hoon Min
  • Jae J. Kim
  • Kee-Taek Jang
  • Kyoung-Mee Kim
  • Cheol Keun Park


Background and study aims

There are often discrepancies between the pretreatment evaluation of gastric neoplasms by endoscopy with biopsy and the final diagnosis of resected specimen in terms of pathology and depth of invasion. We evaluated the spectrum of discrepancies between pretreatment and posttreatment diagnosis which may deliver significant differences on clinical practice.

Patients and methods

A total of 2041 patients with gastric dysplasia or cancer who underwent curative endoscopic resections or surgeries in 2012 were enrolled. Patients were classified into five different diagnostic groups: low-grade dysplasia (LGD), high-grade dysplasia (HGD), absolute indication early gastric cancer (AI-EGC), beyond absolute indication early gastric cancer (BAI-EGC), and advanced gastric cancer (AGC). The choice of initial treatment and final pathologic diagnosis was analyzed.


The study patients belonged to the following pretreatment diagnostic groups: LGDs in 162, HGDs in 164, AI-EGCs in 396, BAI-EGCs in 824, and AGCs in 495 cases. Posttreatment diagnostic groups were LGDs in 140, HGDs in 121, AI-EGCs in 322, BAI-EGCs in 947, AGCs in 505, and no residual tumor in 6 cases. In general, 6.9 % (141/2041) of cases were downgraded and 15.9 % (324/2041) were upgraded. Thirty-four percent of pretreatment HGDs (56/164) were changed to cancers after endoscopic resection. Thirty-three percent of pretreatment AI-EGCs (131/396) were regrouped as posttreatment BAI-EGCs. The additional surgery rate in each pretreatment group was 0.6 % in LGD, 4.3 % in HGD, 15.7 % in AI-EGC, 23.6 % in BAI-EGC among the patients with initial endoscopic resection (p < 0.01).


Twenty-three percent of gastric neoplasms changed in their final diagnostic group after endoscopic resection or surgery. This discrepancy should be considered when the initial treatment strategy is being selected.


Stomach neoplasms Diagnosis Endoscopic submucosal dissection 


Compliance with ethical standards


Jun Hee Lee, Yang Won Min, Jun Haeng Lee, Eun Ran Kim, Hyuk Lee, Byung-Hoon Min, Jae J. Kim, Kee-Taek Jang, Kyoung-Mee Kim, and Cheol Keun Park have no conflicts of interest or financial ties to disclose.


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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Jun Hee Lee
    • 1
  • Yang Won Min
    • 1
  • Jun Haeng Lee
    • 1
    Email author
  • Eun Ran Kim
    • 1
  • Hyuk Lee
    • 1
  • Byung-Hoon Min
    • 1
  • Jae J. Kim
    • 1
  • Kee-Taek Jang
    • 2
  • Kyoung-Mee Kim
    • 2
  • Cheol Keun Park
    • 2
  1. 1.Department of Medicine, Samsung Medical CenterSungkyunkwan University School of MedicineSeoulKorea
  2. 2.Department of Pathology, Samsung Medical CenterSungkyunkwan University School of MedicineSeoulKorea

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