Surgical Endoscopy

, Volume 30, Issue 5, pp 1705–1712 | Cite as

Laparoscopic versus open surgery for complicated appendicitis in adults: a randomized controlled trial

  • Yoshiro Taguchi
  • Shunichiro Komatsu
  • Eiji Sakamoto
  • Shinji Norimizu
  • Yuji Shingu
  • Hiroshi Hasegawa



The aim of this study was to assess whether laparoscopic appendectomy (LA) for complicated appendicitis (CA) effectively reduces the incidence of postoperative complications and improves various measurements of postoperative recovery in adults compared with open appendectomy (OA).


This single-center, randomized controlled trial was performed in the Nagoya Daini Red Cross Hospital. Patients diagnosed as having CA with peritonitis or abscess formation were eligible to participate and were randomly assigned to an LA group or an OA group. The primary study outcome was development of infectious complications, especially surgical site infection (SSI), within 30 days of surgery.


Between October 2008 and August 2014, 81 patients were enrolled and randomly assigned with a 1:1 allocation ratio (42, LA; 39, OA). All were eligible for study of the primary endpoint. Groups were well balanced in terms of patient characteristics and preoperative levels of C-reactive protein. SSI occurred in 14 LA group patients (33.3 %) and in 10 OA group patients (25.6 %) (OR 1.450, 95 % CI 0.553–3.800; p = 0.476). Overall, the rate of postoperative complications, including incisional or organ/space SSI and stump leakage, did not differ significantly between groups. No significant differences between groups were found in hospital stay, duration of drainage, analgesic use, or parameters for postoperative recovery except days to walking.


These results suggested that LA for CA is safe and feasible, while the distinguishing benefit of LA was not validated in this clinical trial.


Complicated appendicitis Laparoscopic surgery Open surgery Complication RCT 


Compliance with Ethical Standards


Yoshiro Taguchi, Shunichiro Komatsu, Eiji Sakamoto, Shinji Norimizu, Yuji Shingu, and Hiroshi Hasegawa have no conflict of interest.


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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Yoshiro Taguchi
    • 1
  • Shunichiro Komatsu
    • 1
    • 2
  • Eiji Sakamoto
    • 1
  • Shinji Norimizu
    • 1
  • Yuji Shingu
    • 1
  • Hiroshi Hasegawa
    • 1
  1. 1.Department of Digestive SurgeryNagoya Daini Red Cross HospitalNagoyaJapan
  2. 2.Department of Gastroenterological SurgeryAichi Medical UniversityNagakuteJapan

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