Surgical Endoscopy

, Volume 29, Issue 8, pp 2352–2358 | Cite as

Efficacy and long-term outcome of pre-emptive endoscopic resection and surgery for multiple synchronous gastric cancers

  • Masao Yoshida
  • Naomi KakushimaEmail author
  • Masanori Tokunaga
  • Masaki Tanaka
  • Kohei Takizawa
  • Kenichiro Imai
  • Kinichi Hotta
  • Hiroyuki Matsubayashi
  • Yutaka Tanizawa
  • Etsuro Bando
  • Taiichi Kawamura
  • Masanori Terashima
  • Hiroyuki Ono



In cases of synchronous gastric cancers (SGC) that include one for surgical indication and another for endoscopic resection (ER) in two different regions of the stomach, patients can avoid total gastrectomy and undergo subtotal gastrectomy following successful pre-emptive ER. The aim of this study was to evaluate the feasibility and efficacy of pre-emptive endoscopic resection and surgery (PRES) with curative intent for such SGCs.


Between September 2002 and December 2012, 34 patients with SGCs (72 lesions) underwent PRES. Our institutional principals of PRES ensure the following: (1) treatment with curative intent, (2) multiple lesions indicated for ER and surgery, (3) evasion of TG following successful pre-emptive ER, (4) exclusion of type 4 and large type 3 (>80 mm) tumors, and (5) nonemergent cases such as hemorrhage, perforation, and obstruction. Clinicopathological characteristics and technical data were evaluated for all patients, and long-term outcomes were analyzed in patients who obtained curative ER and underwent subtotal gastrectomy.


Curative ER was obtained in 31 patients (91.1 %), and subtotal gastrectomy was performed a median of 44 days after ER. Final stages were as follows: stage I, 25 patients (80.6 %); stage II, four patients (12.9 %); stage III, one patient (3.2 %); and stage IV, one patient (3.2 %). The 5-year overall and cause-specific survival rates were 96.3 % (95 % confidence interval 89.4–100 %) and 100 %, respectively.


PRES was feasible and effective as the first treatment of choice for multiple SGCs. PRES enables minimally invasive surgery with promising oncological outcomes.


Gastric cancer Endoscopic resection Gastrectomy Minimally invasive surgery Quality of life 



The authors thank the SCC clinical trial management center (Mr. Keita Mori) for data management and helpful comments about statistics.


Masao Yoshida, Naomi Kakushima, Masanori Tokunaga, Masaki Tanaka, Kohei Takizawa, Kenichiro Imai, Kinichi Hotta, Hiroyuki Matsubayashi, Yutaka Tanizawa, Etsuro Bando, Taiichi Kawamura, Masanori Terashima, and Hiroyuki Ono have no conflict of interest or financial ties to disclose.


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Masao Yoshida
    • 1
  • Naomi Kakushima
    • 1
    Email author
  • Masanori Tokunaga
    • 2
  • Masaki Tanaka
    • 1
  • Kohei Takizawa
    • 1
  • Kenichiro Imai
    • 1
  • Kinichi Hotta
    • 1
  • Hiroyuki Matsubayashi
    • 1
  • Yutaka Tanizawa
    • 2
  • Etsuro Bando
    • 2
  • Taiichi Kawamura
    • 2
  • Masanori Terashima
    • 2
  • Hiroyuki Ono
    • 1
  1. 1.Division of EndoscopyShizuoka Cancer CenterSunto-gunJapan
  2. 2.Division of Gastric SurgeryShizuoka Cancer CenterShizuokaJapan

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