Surgical Endoscopy

, Volume 28, Issue 8, pp 2412–2420

Comparative effects of gastric bypass and sleeve gastrectomy on plasma osteopontin concentrations in humans

  • Andoni Lancha
  • Rafael Moncada
  • Víctor Valentí
  • Amaia Rodríguez
  • Victoria Catalán
  • Sara Becerril
  • Beatriz Ramírez
  • Leire Méndez-Giménez
  • María J. Gil
  • Fernando Rotellar
  • Secundino Fernández
  • Javier Salvador
  • Gema Frühbeck
  • Javier Gómez-Ambrosi
Article

DOI: 10.1007/s00464-014-3490-1

Cite this article as:
Lancha, A., Moncada, R., Valentí, V. et al. Surg Endosc (2014) 28: 2412. doi:10.1007/s00464-014-3490-1

Abstract

Background

Bariatric surgery (BS) has proven to be an effective treatment for morbid obesity. Osteopontin (OPN) is a proinflammatory cytokine involved in the development of obesity. The aim of our study was to determine the effect of weight loss following BS on circulating levels of OPN in humans.

Methods

Body composition and circulating concentrations of OPN and markers of bone metabolism were determined in obese patients who underwent Roux-en-Y gastric bypass (RYGB; n = 40) or sleeve gastrectomy (SG; n = 11).

Results

Patients who underwent RYGB or SG showed decreased body weight (P < 0.001) and body fat percentage (P < 0.001) as well as lower insulin resistance. However, plasma OPN levels were significantly increased after RYGB (P < 0.001) but remained unchanged following SG (P = 0.152). Patients who underwent RYGB also showed significantly increased C-terminal telopeptide of type-I collagen (ICTP) (P < 0.01) and osteocalcin (P < 0.001) while bone mineral density tended to decrease (P = 0.086). Moreover, OPN concentrations were positively correlated with the bone resorption marker ICTP after surgery. On the other hand, patients who underwent SG showed significantly increased ICTP levels (P < 0.05), and the change in OPN was positively correlated with the change in ICTP and negatively with the change in vitamin D after surgery (P < 0.05).

Conclusions

RYGB increased circulating OPN levels, while they remained unaltered after SG. The increase in OPN levels after RYGB could be related to the increased bone resorption in relation to its well-known effects on bone of this malabsorptive procedure in comparison to the merely restrictive SG.

Keywords

Osteopontin Roux-en-Y gastric bypass Sleeve gastrectomy Bone 

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Andoni Lancha
    • 1
    • 2
  • Rafael Moncada
    • 3
  • Víctor Valentí
    • 2
    • 4
  • Amaia Rodríguez
    • 1
    • 2
  • Victoria Catalán
    • 1
    • 2
  • Sara Becerril
    • 1
    • 2
  • Beatriz Ramírez
    • 1
    • 2
  • Leire Méndez-Giménez
    • 1
    • 2
  • María J. Gil
    • 2
    • 5
  • Fernando Rotellar
    • 2
    • 4
  • Secundino Fernández
    • 2
    • 6
  • Javier Salvador
    • 2
    • 7
  • Gema Frühbeck
    • 1
    • 2
    • 7
  • Javier Gómez-Ambrosi
    • 1
    • 2
  1. 1.Metabolic Research LaboratoryClínica Universidad de NavarraPamplonaSpain
  2. 2.CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn)Instituto de Salud Carlos IIIPamplonaSpain
  3. 3.Department of AnesthesiaClínica Universidad de NavarraPamplonaSpain
  4. 4.Department of SurgeryClínica Universidad de NavarraPamplonaSpain
  5. 5.Department of BiochemistryClínica Universidad de NavarraPamplonaSpain
  6. 6.Department of OtorhinolaryngologyClínica Universidad de NavarraPamplonaSpain
  7. 7.Department of Endocrinology & NutritionClínica Universidad de NavarraPamplonaSpain

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