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Surgical Endoscopy

, Volume 28, Issue 7, pp 2097–2105 | Cite as

Clinicopathologic factors and outcomes of histologic discrepancy between differentiated and undifferentiated types after endoscopic resection of early gastric cancer

  • Choong Nam Shim
  • Hyunki Kim
  • Dong Wook Kim
  • Hyun Soo Chung
  • Jun Chul Park
  • Hyuk Lee
  • Sung Kwan Shin
  • Sang Kil Lee
  • Yong Chan LeeEmail author
Article

Abstract

Background

Histologic discrepancies among specimens obtained by forceps biopsy and endoscopic resection (ER) between the differentiated and undifferentiated types often occur in early gastric cancer (EGC). This study aimed to evaluate the predictive clinicopathologic characteristics and clinical implications of histologic discrepancies in EGC.

Methods

From August 2005 to March 2012, 596 lesions from 579 patients underwent ER for EGC. The lesions studied were diagnosed as the differentiated histologic type from forceps biopsy specimens. The lesions were grouped according to the occurrence of histologic discrepancy between the differentiated and undifferentiated types in specimens obtained by ER as concordant (n = 570) or discordant (n = 26). The main outcome measures were en bloc resection, complete resection, and curative resection rates.

Results

The histologic discrepancy rate was 4.4 % among the studied lesions. Larger size, lesion location in the mid third of the stomach, easy friability, exudates, and submucosal invasion shown on endoscopic ultrasound were significantly related to histologic discrepancy in the univariate analysis. In the multivariate analysis, lesion location in the mid third of the stomach [odds ratio (OR) 5.34, 95 % confidence interval (CI) 1.59–19.13] and easy friability (OR 29.26, 95 % CI 2.30 to >999.9) were significant factors associated with histologic discrepancy. The complete resection and curative resection rates were significantly lower and the additional operation rates after ER were significantly higher in the discordant group.

Conclusions

The EGCs with histologic discrepancy between the differentiated and undifferentiated types changed the therapeutic outcomes of ER. Easily friable lesions located in the mid third of the stomach carry a significant risk for histologic discrepancy in undifferentiated histology when ER of EGCs is performed.

Keywords

Early gastric cancer Endoscopic resection Histology Discrepancy 

Abbreviations

ER

Endoscopic resection

EGC

Early gastric cancer

EUS

Endoscopic ultrasound

EMR

Endoscopic mucosal resection

ESD

Endoscopic submucosal dissection

Notes

Disclosures

Choong Nam Shim, Hyunki Kim, Dong Wook Kim, Hyun Soo Chung, Jun Chul Park, Hyuk Lee, Sung Kwan Shin, Sang Kil Lee, and Yong Chan Lee have no conflicts of interest or financial ties to disclose.

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Choong Nam Shim
    • 1
  • Hyunki Kim
    • 2
  • Dong Wook Kim
    • 3
  • Hyun Soo Chung
    • 1
  • Jun Chul Park
    • 1
  • Hyuk Lee
    • 1
  • Sung Kwan Shin
    • 1
  • Sang Kil Lee
    • 1
  • Yong Chan Lee
    • 1
    Email author
  1. 1.Department of Internal Medicine, Institute of GastroenterologyYonsei University College of MedicineSeoulKorea
  2. 2.Department of PathologyYonsei University College of MedicineSeoulKorea
  3. 3.Biostatistics Collaboration UnitYonsei University College of MedicineSeoulKorea

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