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Surgical Endoscopy

, Volume 28, Issue 6, pp 1753–1773 | Cite as

EAES recommendations for the management of gastroesophageal reflux disease

  • Karl Hermann FuchsEmail author
  • Benjamin Babic
  • Wolfram Breithaupt
  • Bernard Dallemagne
  • Abe Fingerhut
  • Edgar Furnee
  • Frank Granderath
  • Peter Horvath
  • Peter Kardos
  • Rudolph Pointner
  • Edoardo Savarino
  • Maud Van Herwaarden-Lindeboom
  • Giovanni Zaninotto
Consensus Statement

Abstract

Background

Gastroesophageal reflux disease (GERD) is one of the most frequent benign disorders of the upper gastrointestinal tract. Management of GERD has always been controversial since modern medical therapy is very effective, but laparoscopic fundoplication is one of the few procedures that were quickly adapted to the minimal access technique. The purpose of this project was to analyze the current knowledge on GERD in regard to its pathophysiology, diagnostic assessment, medical therapy, and surgical therapy, and special circumstances such as GERD in children, Barrett’s esophagus, and enteroesophageal and duodenogastroesophageal reflux.

Methods

The European Association of Endoscopic Surgery (EAES) has tasked a group of experts, based on their clinical and scientific expertise in the field of GERD, to establish current guidelines in a consensus development conference. The expert panel was constituted in May 2012 and met in September 2012 and January 2013, followed by a Delphi process. Critical appraisal of the literature was accomplished. All articles were reviewed and classified according to the hierarchy of level of evidence and summarized in statements and recommendations, which were presented to the scientific community during the EAES yearly conference in a plenary session in Vienna 2013. A second Delphi process followed discussion in the plenary session.

Results

Recommendations for pathophysiologic and epidemiologic considerations, symptom evaluation, diagnostic workup, medical therapy, and surgical therapy are presented. Diagnostic evaluation and adequate selection of patients are the most important features for success of the current management of GERD. Laparoscopic fundoplication is the most important therapeutic technique for the success of surgical therapy of GERD.

Conclusions

Since the background of GERD is multifactorial, the management of this disease requires a complex approach in diagnostic workup as well as for medical and surgical treatment. Laparoscopic fundoplication in well-selected patients is a successful therapeutic option.

Keywords

GERD Gastroesophageal reflux disease Laparoscopic fundoplication Barrett’s esophagus Proton pump inhibitor PPI 

Notes

Acknowledgments

The panelists express their gratitude to the EAES and the scientific community during the 21st EAES Congress 2013 in Vienna for their support of this work.

Disclosures

Karl Hermann Fuchs, Benjamin Babic, Wolfram Breithaupt, Bernard Dallemagne, Abe Fingerhut, Edgar Furnee, Frank Granderath, Peter Horvath, Peter Kardos, Rudolph Pointner, Edoardo Savarino, Maud Van Herwaarden-Lindeboom, and Giovanni Zaninotto have no conflicts of interest or financial ties to disclose.

References

  1. 1.
    Eypasch E, Neugebauer E, Fischer F, Troidl H (1997) Laparoscopic antireflux surgery for gastroesophageal reflux disease (GERD). Results of a consensus development conference. Surg Endosc 11:413–426Google Scholar
  2. 2.
    Fuchs KH, Feussner H, Bonavina L, Collard JM, Coosemans W, European Study Group for Antireflux Surgery (1997) Current status and trends in laparoscopic antireflux surgery: results of a consensus meeting. Endoscopy 29:298–308PubMedGoogle Scholar
  3. 3.
    Dent J, Brun J, Fendrick AM, Fennerry MB, Janssens J et al (1999) Genval Workshop Group: An evidence-based appraisal of reflux disease management. Gut 44:S1–S16PubMedCentralGoogle Scholar
  4. 4.
    Kahrilas PJ, Shaheen NJ, Vaezi MF, Hiltz SW, Black E, Modlin IM, Johnson SP, Allen J, Brill JV (2008) American Gastroenterological Association Medical Position Statement on the management of gastroesophageal reflux disease. Gastroenterology 135:1383–1391PubMedGoogle Scholar
  5. 5.
    Vakil N, van Zanten SV, Kahrilas PJ, Dent J, Jones R, Global Consensus Group (2006) The Montreal Definition and Classification of GERD: a global evidence-based consensus. Am J Gastroenterol 101:1900–1920PubMedGoogle Scholar
  6. 6.
    Stefanidis D, Hope WW, Kohn GP, Reardon PR, Richardson WS, Fanelli RD, SAGES Guideline committee (2010) SAGES guidelines for surgical treatment of GERD. Surg Endosc 24(11):2647–2669PubMedGoogle Scholar
  7. 7.
    Neudecker J, Sauerland S, Neugebauer E, Bergamaschi R, Bonjer HJ, Cuschieri A, Fuchs KH, Jacobi C, JansenFW, Koivusalo AM, Lacy A, McMahon MJ, Millat B, Schwenk W (2002) The European Association for Endoscopic Surgery clinical practice guideline on the pneumoperitoneum for laparoscopic surgery. Surg Endosc 16:1121–1143PubMedGoogle Scholar
  8. 8.
    Neugebauer AM, Becker M, Buess GF, Cuschieri A, Dauben HP, Fingerhut A, Fuchs KH, Habermalz B, Lantsberg L, Morino M, Reiter-Theil S, Soskuty G, Wayand W, Welsch T (2010) EAES recommendations on methodology of innovation management in endoscopic surgery. Surg Endosc 24:1594–1615PubMedGoogle Scholar
  9. 9.
    Center for Evidence Based Medicine, University of Oxford (2011) Level of Evidence, Oxford criteria. www.cebm.net. Accessed 10 Oct 2013
  10. 10.
    Savary M, Miller G (1977) Der Ösophagus. Gassmann Verlag, Solothurn, SwitzerlandGoogle Scholar
  11. 11.
    Lundell LR, Dent J, Bennett JR, Blum AL, Armstrong D, Galmiche JP, Johnson F, Hongo M, Richter JE, Spechler SJ et al (1999) Endoscopic assessment of oesophagitis: clinical and functional correlates and further validation of the Los Angeles classification. Gut 45:172–180PubMedCentralPubMedGoogle Scholar
  12. 12.
    Savarino E, Zentilin P, Savarino V (2013) NERD: an umbrella term including heterogeneous subpopulations. Nat Rev Gastroenterol Hepatol 10:371–380PubMedGoogle Scholar
  13. 13.
    Zentilin P, Savarino V, Mastracci L, Spaggiari P, Dulbecco P, Ceppa P, Savarino E, Parodi A, Mansi C, Fiocca R (2005) Reassessment of the diagnostic value of histology in patients with GERD, using multiple biopsy sites and an appropriate control group. Am J Gastroenterol 100(10):2299–2306PubMedGoogle Scholar
  14. 14.
    DeMeester TR (1987) Definition, detection and pathophysiology of gastroesophageal reflux disease. In: DeMeester TR, Matthews HR (eds) International trends in general thoracic surgery. Benign esophageal disease, vol 3. Mosby, St. Louis, pp 99–127Google Scholar
  15. 15.
    Zaninotto G, DeMeester TR, Schwizer W, Johansson KE, Cheng SC (1988) The lower esophageal sphincter in health and disease. Am J Surg 155:104–111PubMedGoogle Scholar
  16. 16.
    Kuster E, Ros E, Toledo-Pimentel V, Pujol A, Bordas JM, Grande IC (1994) Predictive factors of the long term outcome in gastro-oesophageal reflux disease: six year follow up of 107 patients. Gut 35(1):8–14PubMedCentralPubMedGoogle Scholar
  17. 17.
    Fuchs KH, Freys SM, Heimbucher J, Fein M, Thiede A (1995) Pathophysiologic spectrum in patients with gastroesophageal reflux disease in a surgical GI function laboratory. Dis Esophagus 8:211–217Google Scholar
  18. 18.
    Fein M, Ireland AP, Ritter MP, Peters JH, Hagen JA, Bremner CG, DeMeester TR (1997) Duodenogastric reflux potentiates the injurious effects of gastroesophageal reflux. J Gastrointest Surg 1:27–33PubMedGoogle Scholar
  19. 19.
    Lord RV, DeMeester SR, Peters JH, Hagen JA, Elyssnia D, Sheth CT, DeMeester TR (2009) Hiatal hernia, lower esophageal sphincter incompetence, and effectiveness of nissen fundoplication in the spectrum of gastroesophageal reflux disease. J Gastrointest Surg 13:602–610PubMedGoogle Scholar
  20. 20.
    Fein M, Ritter M, DeMeester TR, Oberg S, Peters JH, Hagen JA, Bremner CG (1999) Role of lower esophageal sphincter and hiatal hernia in the pathogenesis of GERD. J Gastrointest Surg 3(4):405–410PubMedGoogle Scholar
  21. 21.
    Mattioli S, Lugaresi ML, Costantini M, Del Genio A, Di Martino N, Fei L, Fumagalli U, Maffettone V, Monaco L, Morino M, Rebecchi F, Rosati R, Rossi M, Sant S, Trapani V, Zaninotto G (2008) The short esophagus: intraoperative assessment of esophageal length. J Thorac Cardiovasc Surg 136:1610Google Scholar
  22. 22.
    El-Serag H, Hill C, Jones R (2009) Systematic review: the epidemiology of gastro-oesophageal reflux disease in primary care, using the UK General Practice Research Database. Aliment Pharmacol Ther 29:470–480PubMedGoogle Scholar
  23. 23.
    Dent J, El-Serag HB, Wallander MA, Johansson S (2005) Epidemiology of gastro-oesophageal reflux disease: a systematic review. Gut 54:710–717PubMedCentralPubMedGoogle Scholar
  24. 24.
    Ruigomez A, Garcia Rodrıguez LA, Wallander MA, Johansson S, Graffner H, Dent J (2004) Natural history of gastro-oesophageal reflux disease diagnosed in general practice. Aliment Pharmacol Ther 20:751–760PubMedGoogle Scholar
  25. 25.
    Malfertheiner P, Nocon M, Vieth M, Stolte M, Jaspersen D, Koelz HR, Labenz J, Leodolter A, Lind T, Richter K, Willich SN (2012) Evolution of gastro-oesophageal reflux disease over 5 years under routine medical care—the ProGERD study. Aliment Pharmacol Ther 35(1):154–164PubMedGoogle Scholar
  26. 26.
    Rantanen TK, Salo JA (1999) GERD as a cause of death: analysis of fatal cases under conservative therapy. Scand J Gastroenterol 34(3):229–233PubMedGoogle Scholar
  27. 27.
    Kahrilas PJ, Spiess AE (1992) Hiatus hernia. In: Castell DO, Richter J (eds) The Esophagus, 3rd edn. Lippincott Williams & Wilkins, Philadelphia, p 381Google Scholar
  28. 28.
    Jones MP, Sloan SS, Rabine JC (2001) Hiatal hernia size is the dominant determinant of esophagitis presence and severity in gastroesophageal reflux disease. Am J Gastroenterol 96:1711–1717PubMedGoogle Scholar
  29. 29.
    Stylopoulos N, Rattner DW (2005) The history of hiatal hernia surgery: from Bowditch to laparoscopy. Ann Surg 241:185–193PubMedCentralPubMedGoogle Scholar
  30. 30.
    Hill LD (1994) The gastroesophageal flap valve: in vitro and in vivo observations. Gastrointest Endosc 44:541Google Scholar
  31. 31.
    Kamolz T, Granderath Pointner R (2003) Laparoscopic antireflux surgery: disease-related quality of life assessment before and after surgery in GERD patients with and without Barrett’s esophagus. Surg Endosc 17:880–885PubMedGoogle Scholar
  32. 32.
    Oelschlager BK, Pellegrini CA, Hunter J, Soper N, Brunt M, Sheppard B, Jobe B, Polissar N, Mitsumori L, Nelson J, Swanstrom L (2006) Biologic prosthesis reduces recurrence after laparoscopic paraesophageal hernia repair: a multicenter, prospective, randomized trial. Ann Surg 244:481–490PubMedCentralPubMedGoogle Scholar
  33. 33.
    Granderath FA, Carlson MA, Champion JK, Szold A, Basso N, Pointner R, Frantzides CT (2006) Prosthetic closure of the esophageal hiatus in large hiatal hernia repair and laparoscopic antireflux surgery. Surg Endosc 20:367–379PubMedGoogle Scholar
  34. 34.
    Shamiyeh A, Szabo K, Granderath FA, Syré G, Wayand W, Zehetner J (2010) The esophageal hiatus: what is the normal size? Surg Endosc 24(5):988PubMedGoogle Scholar
  35. 35.
    Granderath FA (2007) Measurement of the esophageal hiatus by calculation of the hiatal surface area (HSA). Why, when and how? Surg Endosc 21:2224–2225PubMedGoogle Scholar
  36. 36.
    Klauser AG, Schindlbeck NE, Müller-Lissner SA (1990) Symptoms in gastroesophageal reflux disease. Lancet 335:205–208PubMedGoogle Scholar
  37. 37.
    Costantini M, Crookes PF, Bremner RM, Hoeft SF, Ehsan A, Peters JH, Bremner CG, DeMeester TR (1993) Value of physiologic assessment of foregut symptoms in a surgical practice. Surgery 114(4):780–786PubMedGoogle Scholar
  38. 38.
    Fuchs KH, Ulbricht F, Breithaupt W, Reinisch A, Schulz T, Varga G, Babic B, Musial F (2014) Differentiation between GERD and somatoform disorders in patients with foregut symtoms. Dis Esophagus (in preparation)Google Scholar
  39. 39.
    Savarino E, Zentilin P, Tutuian R, Pohl D, Casa DD, Frazzoni M, Cestari R, Savarino V (2008) The role of nonacid reflux in NERD: lessons learned from impedance-pH monitoring in 150 patients off therapy. Am J Gastroenterol 103(11):2685–2693PubMedGoogle Scholar
  40. 40.
    Vela MF, Camacho-Lobato L, Srinivasan R, Tutuian R, Katz PO, Castell DO (2001) Simultaneous intraesophageal impedance and pH measurement of acid and nonacid gastroesophageal reflux: effect of omeprazole. Gastroenterology 120(7):1599–1606PubMedGoogle Scholar
  41. 41.
    Tack J, Caenepeel P, Arts J, Lee KJ, Sifrim D, Janssens J (2005) Prevalence of acid reflux functional dyspepsia and its association with symptom profile. Gut 54(10):1370–1376PubMedCentralPubMedGoogle Scholar
  42. 42.
    Oustamanolakis P, Tack J (2012) Dyspepsia—organ versus functional. J Clin Gastroenterol 46:175–190PubMedGoogle Scholar
  43. 43.
    Kahrilas PJ, Jonsson A, Denison H, Wernerson B, Hughes N, Howden CW (2012) Concomitant symptoms itemized in the Reflux Disease Questionnaire are associated with attenuated heartburn response to acid suppression. Am J Gastroenterol 107(9):1354–1360PubMedGoogle Scholar
  44. 44.
    Mearin F, Ponce J, Ponce M, Balboa A, Gónzalez MA, Zapardiel J (2012) Frequency and clinical implications of supraesophageal and dyspeptic symptoms in gastroesophageal reflux disease. Eur J Gastroenterol Hepatol 24(6):665–674PubMedGoogle Scholar
  45. 45.
    Savarino E, Pohl D, Zentilin P, Dulbecco P, Sammito G, Sconfienza L, Vigneri S, Camerini G, Tutuian R, Savarino V (2009) Functional heartburn has more in common with functional dyspepsia than with non-erosive reflux disease. Gut 58(9):1185–1191PubMedCentralPubMedGoogle Scholar
  46. 46.
    Gasiorowska A, Poh CH, Fass R (2009) Gastroesophageal reflux disease (GERD) and irritable bowel syndrome (IBS) – is it one disease or an overlap of two disorders? Dig Dis Sci 54(9):1829–1834PubMedGoogle Scholar
  47. 47.
    Savarino V, Savarino E, Parodi A, Dulbecco P (2007) Functional heartburn and non-erosive reflux disease. Dig Dis 25(3):172–174 (review)PubMedGoogle Scholar
  48. 48.
    Grande M, Sileri P, Attinà GM, Villa M, de Luca E, Ciano P, Ciangola CI, Cadeddu F (2012) Nonerosive gastroesophageal reflux disease and mild degree of esophagitis: comparison of symptoms, endoscopic, manometric and pH-metric patterns. World J Surg Oncol 10:84PubMedCentralPubMedGoogle Scholar
  49. 49.
    Zerbib F, Belhocine K, Simon M, Capdepont M, Mion F, Bruley des Varannes S, Galmiche JP (2012) Clinical, but not oesophageal pH-impedance, profiles predict response to proton pump inhibitors in gastro-oesophageal reflux disease. Gut 61(4):501–506PubMedGoogle Scholar
  50. 50.
    Lee JH, Park SY, Cho SB, Lee WS, Park CH, Koh YI, Joo YE, Kim HS, Choi SK, Rew JS (2012) Reflux episode reaching the proximal esophagus are associated with chronic cough. Gut Liver 6(2):197–202PubMedCentralPubMedGoogle Scholar
  51. 51.
    Roberts JR, Aravapalli A, Pohl D, Freeman J, Castell DO (2012) Extraesophageal gastroesophageal reflux disease (GERD) symptoms are not more frequently associated with proximal esophageal reflux than typical GERD symptoms. Dis Esophagus 25(8):678–681PubMedGoogle Scholar
  52. 52.
    Agrawal A, Roberts J, Sharma N, Tutuian R, Vela M, Castell DO (2009) Symptoms with acid and nonacid reflux may be produced by different mechanisms. Dis Esophagus 22(5):467–470PubMedGoogle Scholar
  53. 53.
    Kahrilas PJ, Jonsson A, Denison H, Wernersson B, Hughes N, Howden CW (2012) Regurgitation is less responsive to acid suppression than heartburn in patients with gastroesophageal reflux disease. Clin Gastroenterol Hepatol 10(6):612–619PubMedGoogle Scholar
  54. 54.
    Ours TM, Kavuru MS, Schilz RJ, Richter JED (1999) A prospective evaluation of esophageal testing and a double-blind, randomized study of omeprazole in a diagnostic and therapeutic algorithm for chronic cough. Am J Gastroenterol 94:3131–3138PubMedGoogle Scholar
  55. 55.
    Kiljander TO, Salomaa ER, Hietanen EK, Terho EO (2000) Chronic cough and gastro-esophageal reflux: A double-blind placebo-controlled study with omeprazole. Eur Respir J 16:633–638PubMedGoogle Scholar
  56. 56.
    Allen CJ, Anvari M (1998) Gastro-esophageal reflux related cough and its response to laparoscopic fundoplication. Thorax 53:963–968PubMedCentralPubMedGoogle Scholar
  57. 57.
    Kamel PL, Hanson D, Kahrilas PJ (1994) Prospective trial of omeprazole in the treatment of posterior laryngitis. Am J Med 96:321–326PubMedGoogle Scholar
  58. 58.
    El-Serag HB, Lee P, Buchner A et al (2001) Lansoprazole treatment of patients with chronic idiopathic laryngitis: A placebo-controlled trial. Am J Gastroenterol 96:979–983PubMedGoogle Scholar
  59. 59.
    Sontag SJ, O’Connell S, Khandelwal S et al (2003) Asthmatics with gastro-esophageal reflux: Long term results of a randomized trial of medical and surgical antireflux therapies. Am J Gastroenterol 98:987–999PubMedGoogle Scholar
  60. 60.
    Field SK, Sutherland LR (1998) Does medical antireflux therapy improve asthma in asthmatics with gastroesophageal reflux? A critical review of the literature. Chest 114:275–283PubMedGoogle Scholar
  61. 61.
    Munoz JV, Herreros B, Sanchiz V et al (2003) Dental and periodontal lesions in patients with gastro-esophageal reflux disease. Dig Liver Dis 35:461–467PubMedGoogle Scholar
  62. 62.
    Weaver EM (2003) Association between gastro-esophageal reflux and sinusitis, otitis media, and laryngeal malignancy: a systematic review of the evidence. Am J Med 115:81S–89SPubMedGoogle Scholar
  63. 63.
    Groen JN, Smout AJ (2003) Supra-oesophageal manifestations of gastro-esophageal reflux disease. Eur J Gastroenterol Hepatol 15:1339–1350PubMedGoogle Scholar
  64. 64.
    Savarino E, Bazzica M, Zentilin P, Pohl D, Parodi A, Cittadini G, Negrini S, Indiveri F, Tutuian R, Savarino V, Ghio M (2009) Gastroesophageal reflux and pulmonary fibrosis in scleroderma: a study using pH-impedance monitoring. Am J Respir Crit Care Med 179(5):408–413PubMedGoogle Scholar
  65. 65.
    Savarino E, Carbone R, Marabotto E, Furnari M, Sconfienza L, Ghio M, Zentilin P, Savarino V (2013) Gastro-oesophageal reflux and gastric aspiration in idiopathic pulmonary fibrosis patients. Eur Respir J 42(5):1322–1331PubMedGoogle Scholar
  66. 66.
    Katz PO, Gerson LB, Vela MF (2013) Guidelines for the diagnosis and management of gastroesophageal reflux disease. Gastroenterology 108:308–328Google Scholar
  67. 67.
    Smith JA, Decalmer S, Kelsall A et al (2010) Acoustic cough-reflux associations in chronic cough: potential triggers and mechanisms. Gastroenterology 139:754–762PubMedGoogle Scholar
  68. 68.
    Pacheco-Galvan A, Hart SP, Morice AH (2011) Relationship between gastro-oesophageal reflux and airway diseases: the airway reflux paradigm. Arch Broncopneumol 47:195–203Google Scholar
  69. 69.
    Ayazi S, Hagen JA, Zehetner J et al (2010) Proximal esophageal pH monitoring: improved definition of normal values and determination of a composite pH score. J Am Coll Surg 210:345–350PubMedGoogle Scholar
  70. 70.
    Chang AB, Lasserson TJ, Gaffney J et al (2011) Gastro-oesophageal reflux treatment for prolonged non-specific cough in children and adults. Cochrane Database Syst Rev 1:CD004823PubMedGoogle Scholar
  71. 71.
    Dallemagne B, Weertz J, Markiewicz S, Dewandre JM, Wahlen C, Monami B, Jehaes C (2006) Clinical results of laparoscopic fundoplication ten years after surgery. Surg Endosc 20:159–165PubMedGoogle Scholar
  72. 72.
    Fein M, Bueter M, Thalheimer A, Pachmayer V, Heimbucher J, Freys SM, Fuchs KH (2008) Ten year outcome of laparoscopic antireflux procedures. J Gastrointest Surg 12:1893–1899PubMedGoogle Scholar
  73. 73.
    Martinez SD, Malagon I, Garewal HS et al (2003) Non-erosive reflux disease (NERD)—acid reflux and symptom patterns. Aliment Pharmacol Ther 17:537–545PubMedGoogle Scholar
  74. 74.
    Savarino E, Zentilin P, Mastracci L, Dulbecco P, Marabotto E, Gemignani L, Bruzzone L, de Bortoli N, Frigo AC, Fiocca R, Savarino V (2013) Microscopic esophagitis distinguishes patients with non-erosive reflux disease from those with functional heartburn. J Gastroenterol 48:473–482PubMedGoogle Scholar
  75. 75.
    Zerbib F, des Varannes SB, Roman S, Pouderoux P, Artigue F, Chaput U, Mion F, Caillol F, Verin E, Bommelaer G, Ducrotté P, Galmiche JP, Sifrim D (2005) Normal values and day-to-day variability of 24-h ambulatory oesophageal impedance-pH monitoring in a Belgian-French cohort of healthy subjects. Aliment Pharmacol Ther 22(10):1011–1021PubMedGoogle Scholar
  76. 76.
    Zerbib F, Roman S, Ropert A, des Varannes SB, Pouderoux P, Chaput U, Mion F, Vérin E, Galmiche JP, Sifrim D (2006) Esophageal pH-impedance monitoring and symptom analysis in GERD: a study in patients off and on therapy. Am J Gastroenterol 101(9):1956–1963PubMedGoogle Scholar
  77. 77.
    Mainie I, Tutuian R, Shay S, Vela M, Zhang X, Sifrim D, Castell DO (2006) Acid and non-acid reflux in patients with persistent symptoms despite acid suppressive therapy: a multicentre study using combined ambulatory impedance-pH monitoring. Gut 55(10):1398–1402PubMedCentralPubMedGoogle Scholar
  78. 78.
    Bredenoord AJ, Weusten BL, Timmer R, Smout AJ (2006) Characteristics of gastro-esophageal reflux in symptomatic patients with and without excessive esophageal acid exposure. Am J Gastroenterol 101:2470–2475PubMedGoogle Scholar
  79. 79.
    Hemmink GJ, Bredenoord AJ, Weusten BL, Monkelbaan JF, Timmer R, Smout AJ (2008) Esophageal pH-impedance monitoring in patients with therapy-resistant reflux symptoms: ‘on’ or ‘off’ proton pump inhibitor? Am J Gastroenterol 103(10):2446–2453PubMedGoogle Scholar
  80. 80.
    Kahrilas PJ, Sifrim D (2008) High-resolution manometry and impedance-pH/manometry: valuable tools in clinical and investigational esophagology. Gastroenterology 135(3):756–769PubMedCentralPubMedGoogle Scholar
  81. 81.
    Savarino E, Tutuian R, Zentilin P, Dulbecco P, Pohl D, Marabotto E, Parodi A, Sammito G, Gemignani L, Bodini G, Savarino V (2010) Characteristics of reflux episodes and symptom association in patients with erosive esophagitis and nonerosive reflux disease: study using combined impedance-pH off therapy. Am J Gastroenterol 105:1053–1061PubMedGoogle Scholar
  82. 82.
    Savarino E, Marabotto E, Zentilin P (2011) The added value of impedance-pH monitoring to Rome III criteria in distinguishing functional heartburn from non-erosive reflux disease. Dig Liver Dis 43:542–547PubMedGoogle Scholar
  83. 83.
    Broeders JA, Draaisma WA, Bredenoord AJ, Smout AJ, Broeders IA, Gooszen HG (2011) Impact of symptom-reflux-association analysis on long-term outcome after Nissen fundoplication. Br J Surg 98:247–254PubMedGoogle Scholar
  84. 84.
    Slaughter JC, Goutte M, Rymer JA, Oranu AC, Schneider JA, Garrett CG, Hagaman D, Vaezi MF (2011) Caution about overinterpretation of symptom indexes in reflux monitoring for refractory GERD. Clin Gastroenterol Hepatol 9(19):868–874PubMedGoogle Scholar
  85. 85.
    Campos GM, Peters JH, DeMeester TR et al (1999) Multivariate analysis of factors predicting outcome after laparoscopic Nissen fundoplication. J Gastrointest Surg 3(3):292–300PubMedGoogle Scholar
  86. 86.
    Stein HJ, Barlow AP, DeMeester TR, Hinder RA (1992) Complications of gastroesophageal reflux disease. Role of the lower esophageal sphincter, esophageal acid and acid/alkaline exposure, and duodenogastric reflux. Ann Surg 216(1):35–43PubMedCentralPubMedGoogle Scholar
  87. 87.
    Raman A, Steinbach J, Babajide A, Sheth K, Schwaitzberg S (2010) When does testing for GERD become cost effective in an integrated health network? Surg Endosc 24:1245–1249PubMedGoogle Scholar
  88. 88.
    Savarino E, Gemignani L, Pohl D, Zentilin P, Dulbecco P, Assandri L, Marabotto E, Bonfanti D, Inferrera S, Fazio V, Malesci A, Tutuian R, Savarino V (2011) Oesophageal motility and bolus transit abnormalities increase in parallel with the severity of gastro-oesophageal reflux disease. Aliment Pharmacol Ther 34(4):476–486PubMedGoogle Scholar
  89. 89.
    Kessing BF, Bredenoord AJ, Smout AJ (2011) Erroneous diagnosis of gastroesophageal reflux disease in achalasia. Clin Gastroenterol Hepatol 9(12):1020–1024PubMedGoogle Scholar
  90. 90.
    Ang D, Ang TL, Teo EK, Hsu PP, Tee A, Poh CH, Tan J, Ong J, Fock KM (2011) Is impedance pH monitoring superior to the conventional 24-h pH-monitoring in the evaluation of patients with laryngorespiratory symptoms suspected to be due to gastroesophageal reflux disease? J Dig Dis 12:341–348PubMedGoogle Scholar
  91. 91.
    de Bortoli N, Nacci A, Savarino E, Martinucci I, Bellini M, Fattori B, Ceccarelli L, Costa F, Mumolo MG, Ricchiuti A, Savarino V, Berrettini S, Marchi S (2012) How many cases of laryngopharyngeal reflux suspected by laryngoscopy are gastroesophageal reflux disease-related? World J Gastroenterol 18(32):4363–4370PubMedCentralPubMedGoogle Scholar
  92. 92.
    Chan WW, Haroian LR, Gyawali CP (2011) Value of preoperative esophageal function studies before laparoscopic antireflux surgery. Surg Endosc 25:2943–2949PubMedGoogle Scholar
  93. 93.
    Tack J, Koek G, Demedts I, Sifrim D, Janssens J (2004) Gastroesophageal reflux disease poorly responsive to single-dose proton pump inhibitors in patients without Barrett’s esophagus: acid reflux, bile reflux, or both? Am J Gastroenterol 99:981–988PubMedGoogle Scholar
  94. 94.
    Fein M, Maroske J, Fuchs KH (2006) Importance of duodenogastric reflux in gastro-oesophageal reflux disease. Br J Surg 93(12):1475–1482PubMedGoogle Scholar
  95. 95.
    Wayman J, Myers JC, Jamieson GG (2007) Preoperative gastric emptying and patterns of reflux as predictors of outcome after laparoscopic fundoplication. Br J Surg 94(5):592–598PubMedGoogle Scholar
  96. 96.
    DeVault KR, Castell DO, American College of Gastroenterology (2005) Updated guidelines for the diagnosis and treatment of gastroesophageal reflux disease. Am J Gastroenterol 100(1):190–200PubMedGoogle Scholar
  97. 97.
    Revicki DA, Crawley JA, Zodet MW, Levine DS, Joelsson BO (1999) Complete resolution of heartburn symptoms and health-related quality of life in patients with GERD. Aliment Pharmacol Ther 13(12):1621–1630PubMedGoogle Scholar
  98. 98.
    Mathias SD, Colwell HH, Miller DP, Pasta DJ, Henning JM, Ofman JJ (2001) Health-related quality-of-life and quality-days incrementally gained in symptomatic nonerosive GERD patients treated with lansoprazole or ranitidine. Dig Dis Sci 46(11):2416–2423PubMedGoogle Scholar
  99. 99.
    Savarino V, Dulbecco P (2004) Optimizing symptom relief and preventing complications in adults with gastro-oesophageal reflux disease. Digestion 69(Suppl 1):9–16PubMedGoogle Scholar
  100. 100.
    Becher A, El-Serag H (2011) Systematic review: the association between symptomatic response to proton pump inhibitors and health-related quality of life in patients with gastro-oesophageal reflux disease. Aliment Pharmacol Ther 34(6):618–627PubMedGoogle Scholar
  101. 101.
    Lind T, Havelund T, Carlsson R et al (1997) Heartburn without esophagitis: efficacy of omeprazole therapy and features determining therapeutic response. Scand J Gastroenterol 32:974–979PubMedGoogle Scholar
  102. 102.
    Kitchin LI, Castell DO (1991) Rationale and efficacy of conservative therapy for gastroesophageal reflux disease. Arch Intern Med 151(3):448–454PubMedGoogle Scholar
  103. 103.
    Harvey RF, Gordon PC, Hadley N, Long DE, Gill TR, Macpherson RI (1987) Effects of sleeping with the bed-head raised and of ranitidine in patients with severe peptic oesophagitis. Lancet 2:1200–1203PubMedGoogle Scholar
  104. 104.
    El-Serag H (2008) Role of obesity in GORD-related disorders. Gut 57:281–284PubMedGoogle Scholar
  105. 105.
    Savarino E, Zentilin P, Marabotto E, Bonfanti D, Inferrera S, Assandri L, Sammito G, Gemignani L, Furnari M, Dulbecco P, Savarino V (2011) Overweight is a risk factor for both erosive and non-erosive reflux disease. Dig Liver Dis 43(12):940–945PubMedGoogle Scholar
  106. 106.
    Pace F, Coudsy B, DeLemos B et al (2011) Does BMI affect the clinical efficacy of proton pump inhibitor therapy in GERD? The case for rabeprazole. Eur J Gastroenterol Hepatol 23(10):845–851PubMedGoogle Scholar
  107. 107.
    Maton PN, Burton ME (1999) Antacids revisited: a review of their clinical pharmacology and recommended therapeutic use. Drugs 57:855–870PubMedGoogle Scholar
  108. 108.
    Zentilin P, Dulbecco P, Savarino E, Parodi A, Iiritano E, Bilardi C, Reglioni S, Vigneri S, Savarino V (2005) An evaluation of the antireflux properties of sodium alginate by means of combined multichannel intraluminal impedance and pH-metry. Aliment Pharmacol Ther 21:29–34PubMedGoogle Scholar
  109. 109.
    Giannini EG, Zentilin P, Dulbecco P, Iiritano E, Bilardi C, Savarino E, Mansi C, Savarino V (2006) A comparison between sodium alginate and magaldrate anhydrous in the treatment of patients with gastroesophageal reflux symptoms. Dig Dis Sci 51:1904–1909PubMedGoogle Scholar
  110. 110.
    Kwiatek MA, Roman S, Fareeduddin A, Pandolfino JE, Kahrilas PJ (2011) An alginate-antacid formulation (Gaviscon Double Action Liquid) can eliminate or displace the postprandial ‘acid pocket’ in symptomatic GERD patients. Aliment Pharmacol Ther 34:59–66PubMedCentralPubMedGoogle Scholar
  111. 111.
    Savarino E, de Bortoli N, Zentilin P, Martinucci I, Bruzzone L, Furnari M, Marchi S, Savarino V (2012) Alginate controls heartburn in patients with erosive and nonerosive reflux disease. World J Gastroenterol 18(32):4371–4378PubMedCentralPubMedGoogle Scholar
  112. 112.
    DeVault KR, Castell DO (1995) Guidelines for the diagnosis and treatment of gastroesophageal reflux disease. Practice Parameters Committee of the American College of Gastroenterology. Arch Intern Med 155(20):2165–2173PubMedGoogle Scholar
  113. 113.
    Chiba N, De Gara CJ, Wilkinson JM, Hunt RH (1997) Speed of healing and symptom relief in grade II to IV gastroesophageal reflux disease: a meta-analysis. Gastroenterology 112(6):1798–1810PubMedGoogle Scholar
  114. 114.
    Mainie I, Tutuian R, Castell DO (2008) Addition of a H2 receptor antagonist to PPI improves acid control and decreases nocturnal acid breakthrough. J Clin Gastroenterol 42(6):676–679PubMedGoogle Scholar
  115. 115.
    Qvigstad G, Arnestad JS, Brenna E, Waldum HL (1998) Treatment with proton pump inhibitors induces tolerance to histamine-2 receptor antagonists in Helicobacter pylori-negative patients. Scand J Gastroenterol 33:1244–1248PubMedGoogle Scholar
  116. 116.
    Vigneri S, Termini R, Leandro G, Badalamenti S, Pantalena M, Savarino V, Di Mario F, Battaglia G, Mela GS, Pilotto A et al (1995) A comparison of five maintenance therapies for reflux esophagitis. N Engl J Med 333(17):1106–1110PubMedGoogle Scholar
  117. 117.
    Galmiche JP, Hatlebakk J, Attwood S, Ell C, Fiocca R, Eklund S, Långström G, Lind T, Lundell L, LOTUS Trial Collaborators (2011) Laparoscopic antireflux surgery vs esomeprazole treatment for chronic GERD: the LOTUS randomized clinical trial. JAMA 305(19):1969–1977PubMedGoogle Scholar
  118. 118.
    Chen J, Yuan JC, Leontiadis GI, Howden CW (2012) Recent safety concerns with proton pump inhibitors. J Clin Gastroenterol 46:93–114PubMedGoogle Scholar
  119. 119.
    Savarino V, Di Mario F, Scarpignato C (2009) Proton pump inhibitors in GORD: an overview of their pharmacology, efficacy and safety. Pharmacol Res 59(3):135–153PubMedGoogle Scholar
  120. 120.
    Edwards SJ, Lind T, Lundell L (2001) Systematic review of proton pump inhibitors for the acute treatment of reflux oesophagitis. Aliment Pharmacol Ther 15:1729–1736PubMedGoogle Scholar
  121. 121.
    Castell DO, Kahrilas PJ, Richter JE, Vakil NB, Johnson DA, Zuckerman S et al (2002) Esomeprazole (40 mg) compared with lansoprazole (30 mg) in the treatment of erosive esophagitis. Am J Gastroenterol 97:575–583PubMedGoogle Scholar
  122. 122.
    Dekkers CP, Beker JA, Thjodleifsson B, Gabryelewicz A, Bell NE, Humphries TJ (1999) Double-blind comparison [correction of double-blind, placebo-controlled comparison] of rabeprazole 20 mg vs. omeprazole 20 mg in the treatment of erosive or ulcerative gastro-oesophageal reflux disease. The European Rabeprazole Study Group. Aliment Pharmacol Ther 13(1):49–57PubMedGoogle Scholar
  123. 123.
    Hatlebakk JG, Katz PO, Camacho-Lobato L, Castell DO (2000) Proton pump inhibitors: better acid suppression when taken before a meal than without a meal. Aliment Pharmacol Ther 14(10):1267–1272PubMedGoogle Scholar
  124. 124.
    van Rensburg CJ, Honiball PJ, Grundling HD, van Zyl JH, Spies SK, Eloff FP, Simjee AE, Segal I, Botha JF, Cariem AK, Marks IN, Theron I, Bethke TD (1996) Efficacy and tolerability of pantoprazole 40 mg versus 80 mg in patients with reflux oesophagitis. Aliment Pharmacol Ther 10(3):397–401PubMedGoogle Scholar
  125. 125.
    Fass R, Murthy U, Hayden CW, Malagon IB, Pulliam G, Wendel C, Kovacs TO (2000) Omeprazole 40 mg once a day is equally effective as lansoprazole 30 mg twice a day in symptom control of patients with gastro-oesophageal reflux disease (GERD) who are resistant to conventional-dose lansoprazole therapy - a prospective, randomized, multi-centre study. Aliment Pharmacol Ther 14(12):1595–1603PubMedGoogle Scholar
  126. 126.
    Frazzoni M, De Micheli E, Grisendi A, Savarino V (2003) Effective intra-oesophageal acid suppression in patients with gastro-oesophageal reflux disease: lansoprazole vs. pantoprazole. Aliment Pharmacol Ther 17(2):235–241PubMedGoogle Scholar
  127. 127.
    Katzka DA, Paoletti V, Leite L, Castell DO (1996) Prolonged ambulatory pH monitoring in patients with persistent gastroesophageal reflux disease symptoms: testing while on therapy identifies the need for more aggressive anti-reflux therapy. Am J Gastroenterol 91(10):2110–2113PubMedGoogle Scholar
  128. 128.
    Lundell L, Miettinen P, Myrvold HE, Pedersen SA, Thor K, Lamm M, Blomqvist A, Hatlebakk JG, Janatuinen E, Levander K, Nyström P, Wiklund I (2000) Long-term management of gastro-oesophageal reflux disease with omeprazole or open antireflux surgery: results of a prospective, randomized clinical trial. The Nordic GORD Study Group. Eur J Gastroenterol Hepatol 12(8):879–887PubMedGoogle Scholar
  129. 129.
    Sifrim D, Zerbib F (2012) Diagnosis and management of patients with reflux symptoms refractory to proton pump inhibitors. Gut 61(9):1340–1354PubMedGoogle Scholar
  130. 130.
    Savarino E, Marabotto E, Zentilin P, Frazzoni M, Sammito G, Bonfanti D, Sconfienza L, Assandri L, Gemignani L, Malesci A, Savarino V (2011) The added value of impedance-pH monitoring to Rome III criteria in distinguishing functional heartburn from non-erosive reflux disease. Dig Liver Dis 43(7):542–547PubMedGoogle Scholar
  131. 131.
    Brogden RN, Carmine AA, Heel RC, Speight TM, Avery GS (1982) Domperidone. A review of its pharmacological activity, pharmacokinetics and therapeutic efficacy in the symptomatic treatment of chronic dyspepsia and as an antiemetic. Drugs 24(5):360–400 (review)PubMedGoogle Scholar
  132. 132.
    Ganzini L, Casey DE, Hoffman WF, McCall AL (1993) The prevalence of metoclopramide-induced tardive dyskinesia and acute extrapyramidal movement disorders. Arch Intern Med 153(12):1469–1475PubMedGoogle Scholar
  133. 133.
    Metha S, Bennett J, Mahon D, Rhodes M (2006) Prospective trial of laparoscopic Nissen fundoplication versus proton pump inhibitor therapy for gastroesophageal reflux disease: seven-year follow-up. J Gastrointest Surg 10(9):1312–1317Google Scholar
  134. 134.
    Anvari M, Allen C, Marshall J, Armstrong D, Goree R, Ungar W, Goldsmith C (2011) A randomized controlled trial of laparoscopic Nissen fundoplication versus proton pump inhibitors for the treatment of patients with chronic gastrooesophageal reflux disease (GERD): 3 year outcomes. Surg Endosc 25(8):2547–2554PubMedGoogle Scholar
  135. 135.
    Faria R, Bojke L, Epstein D, Corbacho B, Sculpher M on behalf of the REFLUX trial group (2013) Cost effectiveness of laparoscopic fundoplication versus continued medical management for the treatment of GERD based on long-term follow-up of the REFLUX trial. Br J Surg 100:1205–1213Google Scholar
  136. 136.
    Wileman SM, McCann S, Grant AM, Krukowski ZH, Bruce J (2010) Medical versus surgical management for GERD in adults. Cochrane Database Syst Rev 3:CD003243PubMedGoogle Scholar
  137. 137.
    Frazzoni M, Piccoli M, Conigliaro R, Manta R, Frazzoni L, Melotti G (2013) Refractory gastroesophageal reflux disease as diagnosed by impedance-pH monitoring can be cured by laparoscopic fundoplication. Surg Endosc 27(8):2940–2946PubMedGoogle Scholar
  138. 138.
    Broeders JA, Bredenoord AJ, Hazebroek EJ, Broeders IA, Gooszen HG, Smout AJ (2011) Effects of anti-reflux surgery on weakly acidic reflux and belching. Gut 60(4):435–441PubMedGoogle Scholar
  139. 139.
    Rydberg L, Ruth M, Abrahamsson H, Lundell L (1999) Tailoring antireflux surgery: a randomized clinical trial. World J Surg 23:612–618PubMedGoogle Scholar
  140. 140.
    Fibbe C, Layer P, Keller J, Strate U, Emmermann A, Zornig C (2001) Esophageal motility in reflux disease before and after fundoplication: a prospective, randomized, clinical, and manometric study. Gastroenterology 121:5–14PubMedGoogle Scholar
  141. 141.
    Strate U, Emmermann A, Fibbe C, Layer P, Zornig C (2008) Laparoscopic fundoplication: Nissen versus Toupet two-year outcome of prospective randomized study of 200 patients regarding preoperative esophaegal motility. Surg Endosc 22:21–30PubMedGoogle Scholar
  142. 142.
    Novitsky YW, Wong J, Kercher KW, Litwin DE, Swanstrom LL, Heniford BT (2007) Severely disordered esophageal peristalsis is not a contraindication to laparoscopic Nissen fundoplication. Surg Endosc 21:950–954PubMedGoogle Scholar
  143. 143.
    Watson DI, Jamieson GG, Bessell JR, Devitt PG (2006) Laparoscopic fundoplication in patients with an aperistaltic esophagus and gastroesophageal reflux. Dis Esophagus 19:94–98PubMedGoogle Scholar
  144. 144.
    Broeders JA, Sportel IG, Jamieson GG, Nijjar RS, Granchi N, Myers JC, Thompson SK (2011) Impact of ineffective oesophageal motility and wrap type on dysphagia after laparoscopic fundoplication. Br J Surg 98:1414–1421PubMedGoogle Scholar
  145. 145.
    Pizza F, Rosetti G, Del Genio G, Maffettone V, Brusciano L, Del Genio A (2008) Influence of esophageal motility in the outcome of laparoscopic total fundoplication. Dis Esophagus 21:78–85PubMedGoogle Scholar
  146. 146.
    Broeders JA, Draaisma WA, Bredenoord AJ, Smout AJ, Broeders IA, Gooszen HG (2010) Long-term outcome of Nissen fundoplication in non-erosive and erosive gastro-oesophageal reflux disease. Br J Surg 97:845–852PubMedGoogle Scholar
  147. 147.
    Broeders JA, Draaisma WA, Bredenoord AJ, de Vries DR, Rijnhart-de Jong HG, Smout AJ, Gooszen HG (2009) Oesophageal acid hypersensitivity is not a contraindication to Nissen fundoplication. Br J Surg 96(9):1023–1030PubMedGoogle Scholar
  148. 148.
    Allen CJ, Anvari M (2004) Does laparoscopic fundoplication provide long-term control of GERD related cough? Surg Endosc 18(4):633–637PubMedGoogle Scholar
  149. 149.
    Mainie I, Tutuian R, Agrawal A et al (2006) Combined multichannel-intraluminal impedance-pH monitoring to select patients with persistent gastro-oesophageal reflux for laparoscopic Nissen fundoplication. Br J Surg 93:1483–1487PubMedGoogle Scholar
  150. 150.
    Kaufmann JA, Houghland JE, Quiroga E, Cahill M, Pellegrini CA, Oelschlager BK (2006) Long-term outcomes of laparoscopic antireflux surgery for gastroesophageal reflux disease (GERD)-related airway disorder. Surg Endosc 20:1824–1830Google Scholar
  151. 151.
    Catania RA, Kavic SM, Roth S, Lee TH, Meyer T, Fantry GT, Castellanos PF, Park A (2007) Laparoscopic Nissen fundoplication effectively relieves symptoms in patient with laryngopharyngeal reflux. J Gastrointest Surg 11:1579–1588PubMedGoogle Scholar
  152. 152.
    Salminen P, Sala E, Koskenvuo J, Karvonen J, Ovaska J (2007) Reflux laryngitis: a feasible indication for laparoscopic antireflux surgery. Surg Laparosc Endosc Percutan Tech 17:73–78PubMedGoogle Scholar
  153. 153.
    Barry DW, Vaezi MF (2010) Laryngopharyngeal reflux: more questions than answers. Cleve Clin J Med 77:327–334PubMedGoogle Scholar
  154. 154.
    Zainabadi K, Courcoulas AP, Awais O, Raftopoulos I (2008) Laparoscopic revision of Nissen fundoplication to Roux-en-Y gastric bypass in morbidly obese patients. Surg Endosc 22(12):2737–2740PubMedGoogle Scholar
  155. 155.
    Braghetto I, Korn O, Csendes A, Gutierrez L, Valladares H, Chacon M (2012) Laparoscopic treatment of obese patients with GERD and Barrett’s esophagus: a prospective study. Obes Surg 22(5):764–772PubMedGoogle Scholar
  156. 156.
    Nissen R (1956) Eine einfache operation zur Beeinflussung des Refluxösophagitis. Schweiz Med Wschr 86:590PubMedGoogle Scholar
  157. 157.
    DeMeester TR, Bonavina L, Albertucci M (1986) Nissen fundoplication for gastroesophageal reflux disease. Evaluation of primary repair in 100 consecutive patients. Ann Surg 204(1):9–20PubMedCentralPubMedGoogle Scholar
  158. 158.
    Katkhouda N, Khalil N, Manhas S, Grant S, Velmahos GC, Umbach TW, Kaiser AM (2002) Andre Toupet: surgeon technician par excellence. Ann Surg 235:591–599PubMedCentralPubMedGoogle Scholar
  159. 159.
    Watson DI, Jamieson GG, Pike GK, Davies N, Richardson M, Devitt PG (1999) Prospective randomized double blind trial between laparoscopic Nissen fundoplication and anterior partial fundoplication. Br J Surg 86:123–130PubMedGoogle Scholar
  160. 160.
    Zornig C, Strate U, Fibbe C, Emmermann A, Layer P (2002) Nissen vs Toupet laparoscopic fundoplication. Surg Endosc 16(5):758–766PubMedGoogle Scholar
  161. 161.
    Laws HL, Clements RH, Swillie CM (1997) A randomized, prospective comparison of the Nissen fundoplication versus the Toupet fundoplication for gastroesophageal reflux disease. Ann Surg 225(6):647–653PubMedCentralPubMedGoogle Scholar
  162. 162.
    Watson DI, Jamieson GG, Ludemann R, Game PA, Devitt PG (2004) Laparoscopic total versus anterior 180 degree fundoplication – Five year follow-up of a prospective randomised trial. Dis Esophagus 17(Suppl 1):A81Google Scholar
  163. 163.
    Ludemann R, Watson DI, Jamieson GG, Game PA, Devitt PG (2005) Five-year follow up of a randomized clinical trial of laparoscopic total versus anterior 180 degrees fundoplication. Br J Surg 92(2):240–243PubMedGoogle Scholar
  164. 164.
    Baigrie RJ, Cullis SN, Ndhluni AJ, Cariem A (2005) Randomized double-blind trial of laparoscopic Nissen fundoplication versus anterior partial fundoplication. Br J Surg 92:819–823PubMedGoogle Scholar
  165. 165.
    Spence GM, Watson DI, Jamieson GG, Lally CJ, Devitt PG (2006) Single center prospective randomized trial of laparoscopic Nissen versus anterior 90 degrees fundoplication. J Gastrointest Surg 10:698–705PubMedGoogle Scholar
  166. 166.
    Engström C, Lonroth H, Mardani, Lundell L (2007) An anterior or posterior approach to partial fundoplication? Long-term results of a randomized trial. World J Surg 31(6):1221–1225PubMedGoogle Scholar
  167. 167.
    Guerin E, Betroune K, Closset J, Mehdi A, Lefebre JC, Houben JJ, Gelin M, Vaneukem P, El Nakadi I (2007) Nissen versus Toupet fundoplication: results of a randomized and multicenter trial. Surg Endosc 21:1985–1990PubMedGoogle Scholar
  168. 168.
    Antanas M, Žilvinas E, Mindaugas, Laimas J, Limas K, Almantas M, Juzonas P (2008) Influence of wrap length on the effectiveness of Nissen and Toupet fundoplication: a prospective randomized study. Surg Endosc 22:2269–2276Google Scholar
  169. 169.
    Booth MI, Stratford J, Jones L, Dehn TC (2008) Randomized clinical trial of laparoscopic Nissen versus posterior partial Toupet fundoplication for GERD based on preoperative manometry. Br J Surg 95:57–63PubMedGoogle Scholar
  170. 170.
    Strate U, Emmermann A, Fibbe C, Layer P, Zornig C (2008) Laparoscopic fundoplication: Nissen versus Toupet two-year outcome of prospective randomized study of 200 patients regarding preoperative esophageal motility. Surg Endosc 22:21–30PubMedGoogle Scholar
  171. 171.
    Nijjar RS, Watson D, Jamieson GG, Archer S, Bessell JR, Booth M, Cade R, Cullingford GL, Cullingford GL, Devitt PG, Fletcher DR, Hurley J, Kiroff G, Martin IJ, Nathanson LK, Windsor JA, International Society for the Diseases of the Esophagus-Australasian Section (2010) Five-year follow-up of a multicenter, double-blind randomized clinical trial of laparoscopic Nissen vs. anterior 90° partial fundoplication. Arch Surg 145(6):552–557PubMedGoogle Scholar
  172. 172.
    Shaw JM, Bornmann PC, Callanan MD, Beckingahm IJ, Metz DC (2010) Long-term outcome of laparoscopic Nissen and laparoscopic Toupet fundoplication for gastroesopahgeal reflux disease: a prospective, randomized trial. Surg Endosc 24:924–932PubMedGoogle Scholar
  173. 173.
    Markar SR, Karthikesalingam AP, Wagner OJ, Jackson D, Hewes JC, Vyas S et al (2011) Systematic review and meta-analysis of laparoscopic Nissen fundoplication with or without division of the short gastric vessels. Br J Surg 98:1056–1062PubMedGoogle Scholar
  174. 174.
    Koch OO, Kaindlstorfer A, Antoniou SA, Asche KU, Granderath FA, Pointner R (2012) Laparoscopic Nissen versus Toupet fundoplication: objective and subjective results of a prospective randomized trial. Surg Endosc 26(2):413–422PubMedGoogle Scholar
  175. 175.
    Catarci M, Gentileschi P, Papi C, Carrara A, Marrese R, Gaspari AL, Grassi GB (2004) Evidence-based appraisal of antireflux fundoplication. Ann Surg 239:325–337PubMedCentralPubMedGoogle Scholar
  176. 176.
    Neufeld M, Graham A (2007) Levels of evidence available for techniques in antireflux surgery. Dis Esophagus 20:161–167PubMedGoogle Scholar
  177. 177.
    Varin O, Velstra B, De Sutter S, Ceelen W (2009) Total vs partial fundoplication in the treatment of gastroesophageal reflux disease: a meta-analysis. Arch Surg 144(3):273–278PubMedGoogle Scholar
  178. 178.
    Davis CS, Baldea A, Johns JR, Joehl RJ, Fisichella PM (2010) The evolution and long-term results of laparoscopic antireflux surgery fort he treatment of gastroesophageal reflux disease. JSLS 14(3):332–341PubMedCentralPubMedGoogle Scholar
  179. 179.
    Fein M, Seyfried F (2010) Is there a role for anything other than a Nissen operation? J Gastrointest Surg 14(Suppl 1):S67–S74PubMedGoogle Scholar
  180. 180.
    Broeders JA, Mauritz FA, Ahmed Ali U, Draaisma WA, Ruurda JP, Gooszen HG, Smout AJ, Broeders IA, Hazebroek EJ (2002) Systematic review and meta-analysis of laparoscopic Nissen versus Toupet fundoplication for gastro-esophageal reflux disease. Br J Surg 97:1318–1330Google Scholar
  181. 181.
    Tan G, Yang Z, Wang Z (2011) Meta-analysis of laparoscopic total Nissen versus posterior Toupet fundoplication for GERD based on randomized clinical trials. ANZ J Surg 81:246–252PubMedGoogle Scholar
  182. 182.
    Antoniou SA, Antoniou GA, Koch OO, Pointner R, Granderath FA (2012) Lower recurrence rates after mesh-reinforced versus simple hiatal hernia repair: a meta-analysis of randomized trials. Surg Laparosc Endosc Percutan Tech 22(6):498–502PubMedGoogle Scholar
  183. 183.
    Jobe BA, Wallace J, Hansen PD, Swanström LL (1997) Evaluation of laparoscopic Toupet fundoplication as a primary repair for all patients with medically resistant gastroesophageal reflux. Surg Endosc 11:1080–1083PubMedGoogle Scholar
  184. 184.
    Horvath KD, Jobe BA, Herron DM, Swanström LL (1999) Laparoscopic Toupet fundoplication is an inadequate procedure for patients with severe reflux disease. J Gastrointest Surg 3:583–591PubMedGoogle Scholar
  185. 185.
    Peters JH, DeMeester TR, Crookes P, Oberg S, de Vos Shoop M, Hagen JA, Bremner CG (1998) The treatment of gastroesophageal reflux disease with laparoscopic Nissen fundoplication. Ann Surg 228(1):40–50PubMedCentralPubMedGoogle Scholar
  186. 186.
    Patti MG, Robinson T, Galvani C, Gorodner MV, Fisichella PM, Way LW (2004) Total fundoplication is superior to partial fundoplication even when esophageal peristalsis is weak. J Am Coll Surg 198:863–869PubMedGoogle Scholar
  187. 187.
    Fuchs KH, Breithaupt W, Fein M, Maroske J, Hammer I (2005) Laparoscopic Nissen repair: Indications, techniques and long term benefits. Langenbecks Arch Surg 390:197–202PubMedGoogle Scholar
  188. 188.
    Morgenthal CB, Shane MD, Stival A, Gletsu N, Milam G, Swafford S, Hunter JG, Smith CD (2007) The durability of laparoscopic Nissen fundoplication: 11-year outcome. J Gastrointest Surg 11:693–700PubMedGoogle Scholar
  189. 189.
    Sgromo B, Irvine L, Cuschieri A (2008) Long-term comparative outcome between laparoscopic total Nissen and Toupet fundoplication: Symptomatic relief, patient satisfaction and quality of life. Surg Endosc 22:1048–1053PubMedGoogle Scholar
  190. 190.
    Oelschlager BK, Petersen RP, Brunt LM, Soper NJ, Sheppard BC, Mitsumori L, Rohrmann C, Swanstrom LL, Pellegrini CA (2012) Laparoscopic paraesophageal hernia repair of large, complicated hiatal hernia. J Gastrointest Surg 16(3):453–459PubMedGoogle Scholar
  191. 191.
    Basso N, Rosato P, De Leo A, Genco A, Rea S, Neri T (1999) “Tension-free” hiatoplasty, gastrophenic anchorage and 360 degrees fundoplication in the laparoscopic treatment of paraesophageal hernia. Surg Laparosc Endosc Percutan Tech 9(4):257–262PubMedGoogle Scholar
  192. 192.
    Frantzides CT, Madan AK, Carlson MA, Stavropoulos GP (2002) A prospective randomized trial of laparoscopic polytetrafluoroethylene (PTFE) patch repair vs simple cruroplasty for large hiatal hernia. Arch Surg 137(6):649–652PubMedGoogle Scholar
  193. 193.
    Granderath FA, Schweiger UM, Kamolz T, Asche KU, Pointner R (2005) Laparoscopic Nissen fundoplication with prosthetic hiatal closure reduces postoperative intrathoracic wrap herniation: preliminary results of a prospective randomized functional and clinical study. Arch Surg 140:40–48PubMedGoogle Scholar
  194. 194.
    Granderath FA, Carlson MA, Champion JK, Szold A, Basso N, Pointner R, Frantzides CT (2006) Prosthetic closure of the esophageal hiatus in large hiatal hernia repair and laparoscopic antireflux surgery. Surg Endosc 20:367–379PubMedGoogle Scholar
  195. 195.
    Soricelli E, Basso N, Genco A, Cipriano M (2009) Long-term results of hiatal hernia mesh repair and antireflux laparoscopic surgery. Surg Endosc 23:2499–2504PubMedGoogle Scholar
  196. 196.
    Antoniou SA, Antoniou GA, Berger J, Asche U, Pointner R (2012) Lower recurrence rates after mesh-reinforced versus simple hiatal repair: a meta-analysis of randomized trials. Surg Laparosc Endosc Percutan Tech 22:498–502PubMedGoogle Scholar
  197. 197.
    Targarona EM, Bendahan G, Balague C, Garriga J, Trias M (2004) Mesh in the hiatus: a controversial issue. Arch Surg 139(12):1286–1296PubMedGoogle Scholar
  198. 198.
    Pallabazzer G, Santi S, Parise P, Solito B, Giusti P, Rossi M (2011) Giant hiatal hernias: direct hiatus closure has an acceptable recurrent rate. Updates Surg 63(2):75–81PubMedGoogle Scholar
  199. 199.
    Tatum RP, Shalhub S, Oelschlager BK, Pellegrini CA (2008) Complications of PTFE mesh at the diaphragmatic hiatus. J Gastrointest Surg 12:953–957PubMedGoogle Scholar
  200. 200.
    Stadlhuber RJ, Sherif AE, Mittal SK, Fitzgibbons RJ, Brunt LM, Hunter JG, DeMeester TR, Swanstrom LL, Smith CD, Filipi CJ (2009) Mesh complications after prosthetic reinforcement of hiatal closure: a 28-case series. Surg Endosc 23:1219–1226PubMedGoogle Scholar
  201. 201.
    Parker M, Bowers SP, Bray JM, Harris AS, Belli EV, Pfluke JM, Preissler S, Asbun HJ, Smith CD (2010) Hiatal mesh is associated with major resection at revisional operation. Surg Endosc 24(12):3095–3101PubMedGoogle Scholar
  202. 202.
    Swanstrom LL, Marcus DR, Galloway GQ (1996) Laparoscopic Collis gastroplasty is the treatment of choice for the shortened esophagus. Am J Surg 171(5):477–481PubMedGoogle Scholar
  203. 203.
    Gastal OL, Hagen JH, Campos GM, Hashemi M, Theisen J, Bremner CG, DeMeester TR (1999) Short esophagus: analysis of predictors and clinical implications. Arch Surg 134(6):633–636PubMedGoogle Scholar
  204. 204.
    Youssef YK, Shekar N, Lutfi R, Richards WO, Torquati A (2006) Long-term evaluation of patient satisfaction and reflux symptoms after laparoscopic fundoplicatio with Collis gastroplasty. Surg Endosc 20:1702–1705PubMedGoogle Scholar
  205. 205.
    Metha S, Boddy A, Rhodes M (2006) Review of outcome after laparoscopic paraesophageal hiatal hernia repair. Surg Laparosc Endosc Percutan Tech 16(5):301–306Google Scholar
  206. 206.
    Rathore MA, Andrabi SI, Bhatti MI, Najfi SM, McMurray A (2007) Meta-analysis of recurrence after laparoscopic repair of paraesophageal hernia. JSLS 11(4):456–460PubMedCentralPubMedGoogle Scholar
  207. 207.
    O’Rourke RW, Khajanchee YS, Urbach DR, Lee NN, Lockhart B, Hansen PD, Swanstrom LL (2003) Extended transmediastinal dissection: an alternative to gastroplasty for short esophagus. Arch Surg 138(7):735–740PubMedGoogle Scholar
  208. 208.
    Oelschlager BK, Yamamoto K, Woltman T, Pellegrini C (2008) Vagotomy during hiatal hernia repair: a benign esophageal lengthening procedure. J Gastrointest Surg 12(7):1155–1162PubMedGoogle Scholar
  209. 209.
    Schiefke I, Zabel-Langhennig A, Neumann S, Feisthammel J, Moessner J, Caca K (2005) Long term failure of endoscopic gastroplication (EndoCinch). Gut 54(6):752–758PubMedCentralPubMedGoogle Scholar
  210. 210.
    Triadafilopoulos G, DiBaise JK, Nostrant TT, Stollman NH, Anderson PK, Wolfe MM, Rothstein RI, Wo JM, Corley DA, Patti MG, Antignano LV, Goff JS, Edmundowicz SA, Castell DO, Rabine JC, Kim MS, Utley DS (2002) The Stretta procedure for the treatment of GERD: 6 and 12 months follow-up of the US open-label trial. Gastrointest Endosc 55(2):149–156PubMedGoogle Scholar
  211. 211.
    Schumacher B, Neuhaus H, Ortner M, Laugier R, Benson M, Boyer J, Ponchon T, Hagenmüller F, Grimaud JC, Rampal P, Rey JF, Fuchs KH, Allgaier HP, Hochberger J, Stein HJ, Armengol JA, Siersema PD, Deviere J (2005) Reduced medication dependency and improved symptoms and quality of life 12 months after ENTERYX implantation for GERD. J Clin Gastroenterol 39(3):212–219PubMedGoogle Scholar
  212. 212.
    von Renteln D, Schiefke I, Fuchs KH, Raczynski S, Philipper M, Breithaupt W, Caca K, Neuhaus H (2009) Endoscopic full-thickness plication for the treatment of gastroesophageal reflux disease using multiple plicator implants: 12-month multicenter study results. Surg Endosc 23(8):1866–1875Google Scholar
  213. 213.
    Cadière GB, Van Sante N, Graves JE, Gawlicka AK, Rajan A (2009) Two-year results of a feasibility study on antireflux transoral incisionless fundoplication using EsophyX. Surg Endosc 23(5):957–964PubMedGoogle Scholar
  214. 214.
    Bonavina L, DeMeester T, Fockens P, Dunn D, Saino G, Bona D, Lipham J, Bemelman W, Ganz RA (2010) Laparoscopic sphincter augmentation device eliminates reflux symptoms and normalizes esophageal acid exposure: one- and 2-year results of a feasibility trial. Ann Surg 252(5):857–862PubMedGoogle Scholar
  215. 215.
    Ganz RA, Peters JH, Horgan S, Bemelmann WA, Dunst CM, Edmundowicz SA, Lipham JC, Luketich JD, Melvin WS, Oelschlager BK, Schlack-Haerer SC, Smith CD, Smith CC, Dunn D, Taiganides PA (2013) Esophageal sphincter device for GERD. N Engl J Med 368(8):719–727PubMedGoogle Scholar
  216. 216.
    Pointner R, Bammer T, Then P, Kamolz T (1999) Laparoscopic refundoplications after failed antireflux surgery. Am J Surg 178(6):541–544PubMedGoogle Scholar
  217. 217.
    Donkervoort SC, Bais JE, Rijnhart-de Jong H, Gooszen HG (2003) Impact of anatomical wrap position on the outcome of Nissen fundoplication. Br J Surg 90:854–859PubMedGoogle Scholar
  218. 218.
    Draaisma WA, Rijnhart-de Jong HG, Broeders IA, Smout AJ, Furnee EJ, Gooszen HG (2006) Five-year subjective and objective results of laparoscopic and conventional Nissen fundoplication: a randomized trial. Ann Surg 244:34–41PubMedCentralPubMedGoogle Scholar
  219. 219.
    Furnée EJ, Draaisma WA, Broeders IA, Smout AJ, Vlek AL, Gooszen HG (2008) Predictors of symptomatic and objective outcomes after surgical reintervention for failed antireflux surgery. Br J Surg 95:1369–1374PubMedGoogle Scholar
  220. 220.
    Furnée EJ, Draaisma WA, Broeders IA, Gooszen HG (2009) Surgical reintervention after failed antireflux surgery: a systematic review of the literature. J Gastrointest Surg 13:1539–1549PubMedCentralPubMedGoogle Scholar
  221. 221.
    Kessing BF, Bredenoord AJ, Smout AJ (2011) Erroneous diagnosis of gastroesophageal reflux disease in achalasia. Clin Gastroenterol Hepatol 9(12):1020–1024PubMedGoogle Scholar
  222. 222.
    Luostarinen ME, Isolauri JO, Koskinen MO, Laitinen JO, Matikainen MJ, Lindholm TS (1993) Refundoplication for recurrent gastroesophageal reflux. World J Surg 17:587–593PubMedGoogle Scholar
  223. 223.
    Bonavina L, Chella B, Segalin A, Incarbone R, Peracchia A (1998) Surgical therapy in patients with failed antireflux repairs. Hepatogastroenterology 45:1344–1347PubMedGoogle Scholar
  224. 224.
    Hunter JG, Smith CD, Branum GD, Waring JP, Trus TL, Cornwell M, Galloway K (1999) Laparoscopic fundoplication failures: patterns of failure and response to fundoplication revision. Ann Surg 230:595–604PubMedCentralPubMedGoogle Scholar
  225. 225.
    Heniford BT, Matthews BD, Kercher KW, Pollinger H, Sing RF (2002) Surgical experience in fifty-five consecutive reoperative fundoplications. Am J Surg 68:949–954Google Scholar
  226. 226.
    Dutta S, Bamehriz F, Boghossian T, Pottruff CG, Anvari M (2004) Outcome of laparoscopic redo fundoplication. Surg Endosc 18:440–443PubMedGoogle Scholar
  227. 227.
    Byrne JP, Smithers BM, Nathanson LK, Martin I, Ong HS, Gotley DC (2005) Symptomatic and functional outcome after laparoscopic reoperation for failed antireflux surgery. Br J Surg 92:996–1001PubMedGoogle Scholar
  228. 228.
    Wykypiel H, Kamolz T, Steiner P, Klingler A, Granderath FA, Pointner R, Wetscher GJ (2005) Austrian experience with redo antireflux surgery. Surg Endosc 19(11):1439–1446Google Scholar
  229. 229.
    Furnee EJ, Draaisma WA, Broeders IA, Smout AJ, Gooszen HG (2008) Surgical reintervention after antireflux surgery for gastroesophageal reflux disease: a prospective cohort study in 130 patients. Arch Surg 143:267–274PubMedGoogle Scholar
  230. 230.
    Weusten BL, Roelofs JM, Akkermans LM, Van Berge-Henegouwen GP, Smout AJ (1994) The symptom-association probability: an improved method for symptom analysis of 24-hour esophageal pH data. Gastroenterology 107:1741–1745PubMedGoogle Scholar
  231. 231.
    Kessing BF, Smout AJ, Bredenoord AJ (2012) Clinical applications of esophageal impedance monitoring and high-resolution manometry. Curr Gastroenterol Rep 14:197–205PubMedCentralPubMedGoogle Scholar
  232. 232.
    Yang H, Meun C, Sun X, Watson DI (2012) Outcome following management of dysphagia after laparoscopic anti-reflux surgery. World J Surg 36:838–843PubMedGoogle Scholar
  233. 233.
    Velanovich V, Vallance SR, Gusz JR, Tapia FV, Harkabus MA (1996) Quality of life scale for gastroesophageal reflux disease. J Am Coll Surg 183:217–224PubMedGoogle Scholar
  234. 234.
    Association American Gastroenterological, Spechler SJ, Sharma P, Souza RF, Inadomi JM, Shaheen NJ (2011) American Gastroenterological Association medical position statement on the management of Barrett’s esophagus. Gastroenterology 140:1084–1091Google Scholar
  235. 235.
    Playford RJ (2006) New British Society of Gastroenterology (BSG) guidelines for the diagnosis and management of Barrett’s oesophagus. Gut 3:442–443Google Scholar
  236. 236.
    Reid BJ, Haggitt RC, Rubin LE, Rabinovictch PS (1987) Barrett’s esophagus: correlation between flow cytometry and histology in detection of patients at risk for adenocarcinoma. Gastroenterology 93:1–11PubMedGoogle Scholar
  237. 237.
    Hvid-Jensen F, Pedersen L, Drewes AM, Sorensen HT, Fuch-Jensen P (2011) Incidence of adenocarcinoma in patients with Barrett’s esophagus. New Engl J Med 365(15):1375–1383PubMedGoogle Scholar
  238. 238.
    Rugge M, Zaninotto G, Parente P, Zanatta L et al (2012) Barrett’s esophagus and risk of adenocarcinoma: the experience of the North-East Italian registry (EBRA). Ann Surg 256:788–794PubMedGoogle Scholar
  239. 239.
    Horwhath JD, Baroni D, Maydonowitch C, Osgard E, Orsmeth E et al (2006) Normalization of intestinal metaplasia in the esophagus and esophagogastric junction: incidence and clinical data. Am J Gastroenterol 101:1–10Google Scholar
  240. 240.
    Spechler SJ, Sharma P, Traxler B, Levine D, Falk GW (2006) Gastric and esophageal pH in patients with Barrett’s esophagus treated with three omeprazole dosages: a randomized double-blind crossover trial. Am J Gastroenterol 101:1964–1971PubMedGoogle Scholar
  241. 241.
    Parrilla P, de Martınez Haro ML, Ortiz A, Munitiz V et al (2003) Long-term results of a randomized prospective study comparing medical and surgical treatment of Barrett’s esophagus. Ann Surg 237:2Google Scholar
  242. 242.
    Farrell TM, Smith CD, Metreveli RE, Johnson AB et al (1999) Fundoplication provides effective and durable symptom relief in patients with Barrett’s esophagus. Am J Surg 178:18–21PubMedGoogle Scholar
  243. 243.
    Gurski RA, Peters JH, Hagen JA, DeMeester SD (2003) Barrett’s esophagus can and does regress after antireflux surgery: a study of prevalence and predictive features. J Am Coll Surg 196:706–713PubMedGoogle Scholar
  244. 244.
    Abbas EA, Deschamps C, Cassivi SD, Allen MS et al (2004) Barrett’s esophagus: the role of fundoplication. Ann Thorac Surg 77:393–396PubMedGoogle Scholar
  245. 245.
    Biertho L, Dallemagne B, Dewandre JM, Jehaes C et al (2007) Laparoscopic treatment of Barrett’s esophagus. Long-term results. Surg Endosc 21:11–15PubMedGoogle Scholar
  246. 246.
    Cowgill SM, Al-Saadi S, Villadolid D, Zervos EE, Rosemurgy AS (2006) Does Barrett’s esophagus impact outcome after laparoscopic Nissen fundoplication? Am J Surg 192:622–626PubMedGoogle Scholar
  247. 247.
    Attwood SE, Lundell L, Hatlebakk JG, Eklund S, Junghard O et al (2008) Medical or surgical management of GERD patients with Barrett’s esophagus: the LOTUS trial three-year experience. J Gastrointest Surg 12:1646–1655PubMedGoogle Scholar
  248. 248.
    Caygill CP, Watson A, Lao-Siriex P, Fitzgerald RC (2004) Barrett’s oesophagus and adenocarcinoma. World J Surg Oncol 2:12PubMedCentralPubMedGoogle Scholar
  249. 249.
    Avidan B, Sonnenberg A, Schnell TG, Chejfeg G, Metz A, Sontag SJ (2002) Hiatal hernia size, Barrett’s length and severity of reflux are all risk factors for esophageal adenocarcinoma. Am J Gastroenterol 97:1930–1936PubMedGoogle Scholar
  250. 250.
    Oelschlager BK, Barreca M, Chang L, Oleynikov D, Pellegrini CA (2003) Clinical and pathologic response of Barrett’s esophagus to laparoscopic antireflux surgery. Ann Surg 238:458–466PubMedCentralPubMedGoogle Scholar
  251. 251.
    Zaninotto G, Parente P, Salvador R, Farinati F, Tieppo C et al (2012) Long-term follow-up of Barrett’s epithelium: medical versus antireflux surgical therapy. J Gastrointest Surg 16:7–15PubMedGoogle Scholar
  252. 252.
    Csendes A, Braghetto I, Burdiles P, Smok G et al (2006) Regression of intestinal metaplasia to cardiac or fundic mucosa in patients with Barrett’s esophagus submitted to vagotomy, partial gastrectomy and duodenal diversion. A prospective study of 78 patients with more than 5 years of follow-up. Surgery 139:46–53PubMedGoogle Scholar
  253. 253.
    Zaninotto G, Cassaro M, Pennelli G, Battaglia G, Farinati F et al (2005) Barrett’s epithelium after antireflux surgery. J Gastrointest Surg 9:1253–1261PubMedGoogle Scholar
  254. 254.
    Chang EY, Morris CD, Seltman AK, O’Rourke RW et al (2007) The effect of antireflux surgery on esophageal carcinogenesis in patients with Barrett esophagus: a systematic review. Ann Surg 246:11–21PubMedCentralPubMedGoogle Scholar
  255. 255.
    Corey KE, Schmitz SM, Shaheen NJ (2003) Does a surgical antireflux procedure decrease the incidence of esophageal adenocarcinoma in Barrett’s esophagus? A meta-analysis. Am J Gastroenterol 98:2390–2394PubMedGoogle Scholar
  256. 256.
    Csendes A, Burdiles P, Braghetto I, Korn O (2004) Adenocarcinoma appearing very late after antireflux surgery for Barrett’s esophagus: long-term follow-up, review of the literature, and addition of six patients. J Gastrointest Surg 8:434–441PubMedGoogle Scholar
  257. 257.
    Ortiz A, Martinez de Haro LF, Parrilla P et al (1999) Conservative treatment versus antireflux surgery in Barrett’s oesophagus: long-term results of a prospective study. Br J Surg 83:274–278Google Scholar
  258. 258.
    McDonald ML, Trastek VF, Allen MS et al (1996) Barrett’s esophagus: does an antireflux procedure reduce the need for endoscopic surveillance? J Thorac Cardiovasc Surg 111:1135–1138PubMedGoogle Scholar
  259. 259.
    Lofdahl HE, Lu Y, Lagergren P, Lagergren J (2013) Risk factors for esophageal adenocarcinoma after antireflux surgery. Ann Surg 257:579–582PubMedGoogle Scholar
  260. 260.
    Nelson SP, Chen EH, Syniar GM (1997) Prevalence of symptoms of gastroesophageal reflux during infancy. A pediatric practice-based survey. Pediatric Practice Research Group. Arch Pediatr Adolesc Med 151:569–572PubMedGoogle Scholar
  261. 261.
    Martin AJ, Pratt N, Kennedy JD (2002) Natural history and familial relationships of infant spilling to 9 years of age. Pediatrics 109:1061–1067PubMedGoogle Scholar
  262. 262.
    Stanford EA, Chambers CT, Craig KD (2006) The role of developmental factors in predicting young children’s use of a self-report scale for pain. Pain 120:16–23PubMedGoogle Scholar
  263. 263.
    von Baeyer CL, Spagrud LJ (2007) Systematic review of observational (behavioral) measures of pain for children and adolescents aged 3–18 years. Pain 127:140–150Google Scholar
  264. 264.
    Vandenplas Y, Rudolph CD, Di Lorenzo C, Hassall E, Liptak G, Mazur L, Sondheimer J, Staiano A, Thomson M, Veereman-Wauters G, Wenzl TG, North American Society for Pediatric Gastroenterology Hepatology and Nutrition, European Society for Pediatric Gastroenterology Hepatology and Nutrition (2009) Pediatric gastroesophageal reflux clinical practice guidelines: joint recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPHAN) and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN). J Pediatr Gastroenterol Nutr 49:498–547PubMedGoogle Scholar
  265. 265.
    Gupta SK, Hassall E, Chiu Y-L, Amer F, Heyman MB (2006) Presenting symptoms of nonerosive and erosive esophagitis in pediatric patients. Dig Dis Sci 51:858–863PubMedGoogle Scholar
  266. 266.
    Kinsbourne M (1964) Hiatus hernia with contortions of the neck. Lancet 13:1058–1061Google Scholar
  267. 267.
    Cerimagic D, Ivkic G, Bilic E (2008) Neuroanatomical basis of Sandifer’s syndrome: a new vagal reflex? Med Hypotheses 70:957–961PubMedGoogle Scholar
  268. 268.
    Rasquin A, Di Lorenzo C, Forbes D (2006) Childhood functional gastrointestinal disorders: child/adolescent. Gastroenterology 130:1527–1537PubMedGoogle Scholar
  269. 269.
    Sullivan PB (1997) Gastrointestinal problems in the neurologically impaired child. Baillieres Clin Gastroenterol 11(3):529–546PubMedGoogle Scholar
  270. 270.
    Vandenplas Y, Hassall E (2002) Mechanisms of gastroesophageal reflux and gastroesophageal reflux disease. J Paediatr Gastroenterol Nutr 35:119–136Google Scholar
  271. 271.
    Kawahara H, Dent J, Davidson G (1997) Mechanisms responsible for gastroesophageal reflux in children. Gastroenterology 113:399–408PubMedGoogle Scholar
  272. 272.
    Orenstein SR (1994) Gastroesophageal reflux. In: Hyman PE (ed) Pediatric gastrointestinal motility disorders. Academy Professional Information Services, New York, pp 55–88Google Scholar
  273. 273.
    Furuta GT, Liacouras CA, Collins MH et al (2007) Eosinophilic esophagitis in children and adults: a systematic review and consensus recommendations for diagnosis and treatment. Gastroenterology 133:1342–1363PubMedGoogle Scholar
  274. 274.
    Heine RG, Nethercote M, Rosenbaum J, Allen KJ (2011) Emerging management concepts for eosinophilic esophagitis in children. J Gastroenterol Hepatol 26(7):1106–1113PubMedGoogle Scholar
  275. 275.
    Bohmer CJ, Klinkenberg-Knol EC, Niezen-de Boer MC et al (2000) Gastroesophageal reflux disease in intellectually disabled individuals: how often, how serious, how manageable? Am J Gastroenterol 95:1868–1872PubMedGoogle Scholar
  276. 276.
    Koivusalo A, Pakarinen MP, Rintala RJ (2007) The cumulative incidence of significant gastrooesophageal reflux in patients with oesophageal atresia with a distal fistula—a systematic clinical, pH-metric, and endoscopic follow-up study. J Pediatr Surg 42:370–374PubMedGoogle Scholar
  277. 277.
    Button BM, Roberts S, Kotsimbos TC et al (2005) Gastroesophageal reflux (symptomatic and silent): a potentially significant problem in patients with cystic fibrosis before and after lung transplantation. J Heart Lung Transplant 24:1522–1529PubMedGoogle Scholar
  278. 278.
    Orenstein SR, Shalaby TM, Cohn JF (1996) Reflux symptoms in 100 normal infants: diagnostic validity of the infant gastroesophageal reflux questionnaire. Clin Pediatr 35:607–614Google Scholar
  279. 279.
    Deal L, Gremse DA, Gremse DA, Winter HS, Peters SB, Fraga PD, Mack ME, Gaylord SM, Tolia V, Fitzgerald JF (2005) Age-specific questionnaires distinguish GERD symptom frequency and severity in infants and young children: development and initial validation. J Pediatr Gastroenterol Nutr 41(2):178–185PubMedGoogle Scholar
  280. 280.
    Vandenplas Y, Goyvaerts H, Helven R (1991) Gastroesophageal reflux, as measured by 24-hour pH monitoring, in 509 healthy infants screened for risk of sudden infant death syndrome. Pediatrics 88(4):834–840PubMedGoogle Scholar
  281. 281.
    Loots CM, Benninga MA, Davidson GP, Omari TI (2009) Addition of pH-impedance monitoring to standard pH monitoring increases the yield of symptom association analysis in infants and children with gastroesophageal reflux. J Pediatr 154(2):248–252PubMedGoogle Scholar
  282. 282.
    Thompson JK, Koehler RE, Richter JE (1994) Detection of gastroesophageal reflux: value of barium studies compared with 24-hr pH monitoring. AJR Am J Roentgenol 162:621–626PubMedGoogle Scholar
  283. 283.
    Van Den Driessche M, Veereman-Wauters G (2003) Gastric emptying in infants and children. Acta Gastroenterol Belg 66(4):274–282Google Scholar
  284. 284.
    Sherman PM, Hassall E, Fagundes-Neto U et al (2009) A global, evidence-based consensus on the definition of gastroesophageal reflux disease in the pediatric population. Am J Gastroenterol 104(5):1278–1295PubMedGoogle Scholar
  285. 285.
    Vandenplas Y (1993) Hiatal hernia and gastro-oesophageal reflux. Elsevier Science, Management of Digestive and Liver Disorders in Infants and Children, Amsterdam, pp 103–116Google Scholar
  286. 286.
    Kumar Y, Sarvananthan R (2008) GORD in children. Clin Evid (Online) Pii:0310Google Scholar
  287. 287.
    Mauritz FA, van Herwaarden-Lindeboom MYA, Stomp W et al (2011) The effects and efficacy of antireflux surgery in children with gastroesophageal reflux disease: a systematic review. J Gastrointest Surg 15:1872–1878PubMedCentralPubMedGoogle Scholar
  288. 288.
    Siddiqui MR, Abdulaal Y, Nisar A et al (2011) A meta-analysis of outcomes after open and laparoscopic Nissen’s fundoplication for gastro-oesophageal reflux disease in children. Pediatr Surg Int 27(4):359–366PubMedGoogle Scholar
  289. 289.
    Esposito C, Montupet P, van Der Zee D, Settimi A, Paye-Jaouen A, Centonze A et al (2006) Long-term outcome of laparoscopic Nissen, Toupet, and Thal antireflux procedures for neurologically normal children with gastroesophageal reflux disease. Surg Endosc 20(6):855–858PubMedGoogle Scholar
  290. 290.
    Fonkalsrud EW, Ashcraft KW, Coran AG et al (1998) Surgical treatment of gastroesophageal reflux in children: a combined hospital study of 7467 patients. Pediatrics 101(3 Pt 1):419–422PubMedGoogle Scholar
  291. 291.
    Kubiak R, Andrews J, Grant HW (2011) Long-term outcome of laparoscopic Nissen fundoplication compared with laparoscopic thal fundoplication in children: a prospective, randomized study. Ann Surg 253(1):44–49PubMedGoogle Scholar
  292. 292.
    Mauritz FA, Blomberg BA, van Herwaarden-Lindeboom MYA et al (2013) Complete versus partial fundoplication in children with gastroesophageal reflux disease: results of a systematic review and meta-analysis. J Gastrointest Surg 17(10):1883–1892PubMedGoogle Scholar
  293. 293.
    Stein HJ, Kauer WK, Feussner H, Siewert JR (1999) Bile acids as components of duodenogastric refluate: detection, relationship to bilirubin, mechanism of injury, and clinical relevance. Hepatogastroenterology 46:66–73PubMedGoogle Scholar
  294. 294.
    Bektas H, Schrem H, Lehner F, Schmidt U, Kreczik H, Klempenauer J, Becker T (2006) The value of reoperative procedures after unusual reconstructions in the gastrointestinal tract associated with substantial morbidity. J Gastrointest Surg 10:111–122PubMedGoogle Scholar
  295. 295.
    Fuchs KH, Thiede A, Engemann R, Deltz E, Stremme O, Hamelmann H (1995) Reconstruction of the food passage after total gastrectomy: randomized trial. World J Surg 19:698–705PubMedGoogle Scholar
  296. 296.
    De Corso E, Baroni S, Agostino S, Cammarota G, Mascagna G, Mannocci A, Rignate M, Galli J (2007) Bile acids and total bilirubin detection in saliva of patients submitted to gastric surgery and in particular to subtotal Billroth II resection. Ann Surg 245:880–885PubMedCentralPubMedGoogle Scholar
  297. 297.
    Chan DC, Fan YM, Lin CK, Chen CJ, Chen CY, Chao YC (2007) Roux-en-Y reconstruction after distal gastrectomy to reduce enterogastric reflux and Helicobacter pylori infection. J Gastrointest Surg 11:1732–1740PubMedGoogle Scholar
  298. 298.
    Fein M, Fuchs KH, Thalheimer A, Freys S, Heimbucher J, Thiede A (2008) Long-term benefits of Roux-en-Y pouch reconstruction after total gastrectomy: a randomized trial. Ann Surg 247:759–765PubMedGoogle Scholar
  299. 299.
    Awais O, Luketich JD, Tam J, Irshad K, Schuchert MJ, Landreneau RJ, Pennathur A (2008) Rouy-en-Y near esophago-jejunostomy for intractable gastroesophageal reflux after antireflux surgery. Ann Thorac Surg 85:1954–1961PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Karl Hermann Fuchs
    • 1
    Email author
  • Benjamin Babic
    • 1
  • Wolfram Breithaupt
    • 1
  • Bernard Dallemagne
    • 2
  • Abe Fingerhut
    • 3
  • Edgar Furnee
    • 4
  • Frank Granderath
    • 5
  • Peter Horvath
    • 6
  • Peter Kardos
    • 7
  • Rudolph Pointner
    • 8
  • Edoardo Savarino
    • 9
  • Maud Van Herwaarden-Lindeboom
    • 10
  • Giovanni Zaninotto
    • 11
  1. 1.Department of SurgeryAGAPLESION Markus KrankenhausFrankfurtGermany
  2. 2.IRCAD InstituteStrasbourgFrance
  3. 3.PoissyFrance
  4. 4.University Medical Center UtrechtUtrechtThe Netherlands
  5. 5.Department of SurgeryKrankenhaus NeuwerkMönchengladbachGermany
  6. 6.Department of SurgeryUniversity of PecsPecsHungary
  7. 7.Group Practice & Respiratory UnitMaingau KrankenhausGermany
  8. 8.Department of SurgeryKrankenhaus Zell am SeeZell am SeeAustria
  9. 9.Department of GastroenterologyUniversity of PaduaPaduaItaly
  10. 10.Department of Pediatric SurgeryUniversity of UtrechtUtrechtThe Netherlands
  11. 11.Department of SurgeryImperial CollegeLondonUK

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