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Surgical Endoscopy

, Volume 27, Issue 2, pp 400–405 | Cite as

Intraoperative assessment of esophagogastric junction distensibility during per oral endoscopic myotomy (POEM) for esophageal motility disorders

  • Erwin Rieder
  • Lee L. SwanströmEmail author
  • Silvana Perretta
  • Johannes Lenglinger
  • Martin Riegler
  • Christy M. Dunst
Article

Abstract

Background

Per oral endoscopic myotomy (POEM) is a novel treatment for esophageal motility disorders such as achalasia. To date, the extent of the myotomy has been determined based on the subjective assessment of the endoscopist. We hypothesized that the real-time measurement of esophagogastric junction (EGJ) distensibility using a novel functional lumen-imaging probe would enable objective evaluation of POEM.

Methods

Patients diagnosed with achalasia disorders electively underwent POEM. Using impedance planimetry with a transorally inserted functional lumen-imaging probe (EndoFLIP®), cross-sectional areas (CSA) and distensibilities at the EGJ were measured intraoperatively immediately before and after the transoral myotomy (n = 4). All patients completed their 6-month follow-up and two patients had repeat distensibility tests at this time. Four healthy volunteers served as a control group.

Results

POEM was successfully performed in all patients (4/4). Premyotomy measurements (40-ml fill mode) showed a median diameter of 6.5 mm (range = 5.2–7.9 mm) at the narrowest location of the EGJ and was 10.1 mm (7.3–13.2 mm) following POEM. CSA increased from 41.5 mm2 (20–49 mm2) to 86 mm2 (41–137 mm2) at a similar median intraballoon pressure (40.3 vs. 38.6 mmHg). The increased EGJ distensibility (DI, 1.0 vs. 2.4 mm2/mmHg) was comparable to that of healthy volunteers (2.7 mm2/mmHg).

Conclusion

Functional lumen distensibility measures show that POEM can result in an immediate correction of the nonrelaxing lower esophageal sphincter, which appears similar to that of healthy controls. Intraoperative EGJ profiling may be an important tool to objectively guide the needed extent and completeness of the myotomy during POEM.

Keywords

Achalasia Esophageal motility disorders Myotomy Esophagogastric junction distensibility Endoscopy 

Notes

Acknowledgments

The authors thank Olympus, USA, for providing the high-resolution upper endoscope.

Disclosures

Drs. Rieder, Swanström, Perretta, Lenglinger, Riegler, and Dunst report no conflict of interest with regard to this article and particularly had no financial or editorial involvement from Crospon Inc.

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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Erwin Rieder
    • 1
    • 3
  • Lee L. Swanström
    • 1
    Email author
  • Silvana Perretta
    • 2
  • Johannes Lenglinger
    • 3
  • Martin Riegler
    • 3
  • Christy M. Dunst
    • 1
  1. 1.Gastrointestinal and Minimally Invasive SurgeryThe Oregon ClinicPortlandUSA
  2. 2.Institute de Recherché contra les Cancers de l’Appareil Digestif (IRCAD)Strasbourg CedexFrance
  3. 3.Department of SurgeryMedical University of ViennaViennaAustria

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