Surgical Endoscopy

, Volume 26, Issue 1, pp 261–266 | Cite as

Robot-assisted thymectomy is superior to transsternal thymectomy

  • Benny Weksler
  • Jonathan Tavares
  • Timothy E. Newhook
  • Christopher E. Greenleaf
  • James T. Diehl
Article

Abstract

Background

Complete thymectomy is the procedure of choice in the treatment of thymomas and in treating selected patients with myasthenia gravis. Transsternal thymectomy is the gold standard for most patients. Robot-assisted thymectomy has emerged as an alternative to open transsternal surgery. The goal of this study was to compare perioperative outcomes in patients who underwent transsternal or robot-assisted thymectomy.

Methods

We performed a retrospective review of all patients who underwent robot-assisted or transsternal thymectomy at our institution from February 2001 to February 2010. Data are presented as mean ± SD. Significance was set as P < 0.05.

Results

Fifty patients underwent either transsternal (n = 35) or robot-assisted (n = 15) thymectomy. Patient demographics and the incidence of myasthenia gravis were similar between groups. There were no intraoperative complications or conversions to open surgery in the robot-assisted group. Intraoperative blood loss was significantly higher in the transsternal group (151.43 vs. 41.67 ml, P = 0.01). There were 20 postoperative complications and 1 postoperative death in the transsternal group and 1 postoperative complication in the robot-assisted group (P = 0.001). Hospital length of stay was 4 days (range 2–27 days) in the transsternal group and 1 day (range 1–7 days) in the robot-assisted group (P = 0.002).

Conclusions

Robot-assisted thymectomy is superior to transsternal thymectomy, reducing intraoperative blood loss, postoperative complications, and hospital length of stay. Further investigation of the long-term oncologic results in thymoma patients and long-term remission rates in patients with myasthenia gravis who underwent robot-assisted thymectomy is warranted.

Keywords

Robotic surgery Minimally invasive surgery Thymoma Myasthenia gravis Sternotomy 

Notes

Disclosures

Drs. Benny Weksler, Timothy Newhook, Christopher Greenleaf, James Diehl, and Mr. Jonathan Tavares have no conflicts of interest or financial ties to disclose.

References

  1. 1.
    Skeie GO, Apostolski S, Evoli A, Gilhus NE, Hart IK, Harms L, Hilton-Jones D, Melms A, Verschuuren J, Horge HW (2006) Guidelines for the treatment of autoimmune neuromuscular transmission disorders. Eur J Neurol 13(7):691–699PubMedCrossRefGoogle Scholar
  2. 2.
    Blumberg D, Port JL, Weksler B, Delgado R, Rosai J, Bains MS, Ginsberg RJ, Martini N, McCormack PM, Rusch V et al (1995) Thymoma: a multivariate analysis of factors predicting survival. Ann Thorac Surg 60(4):908–913 (discussion 914)PubMedCrossRefGoogle Scholar
  3. 3.
    McCart JA, Gaspar L, Inculet R, Casson AG (1993) Predictors of survival following surgical resection of thymoma. J Surg Oncol 54(4):233–238PubMedCrossRefGoogle Scholar
  4. 4.
    Meyer DM, Herbert MA, Sobhani NC, Tavakolian P, Duncan A, Bruns M, Korngut K, Williams J, Prince SL, Huber L, Wolfe GI, Mack MJ (2009) Comparative clinical outcomes of thymectomy for myasthenia gravis performed by extended transsternal and minimally invasive approaches. Ann Thorac Surg 87(2):385–390 (discussion 390–391)PubMedCrossRefGoogle Scholar
  5. 5.
    Cheng YJ, Kao EL, Chou SH (2005) Videothoracoscopic resection of stage II thymoma: prospective comparison of the results between thoracoscopy and open methods. Chest 128(4):3010–3012PubMedCrossRefGoogle Scholar
  6. 6.
    Zahid I, Sharif S, Routledge T, Scarci M (2011) Video-assisted thoracoscopic surgery or transsternal thymectomy in the treatment of myasthenia gravis? Interact Cardiovasc Thorac Surg 12(1):40–46PubMedCrossRefGoogle Scholar
  7. 7.
    Berman M, Stamler A, Vidne BA, Saute M (2003) Computer-enhanced thoracoscopic thymectomy with the Zeus telemanipulation surgical system. Interact Cardiovasc Thorac Surg 2(3):262–264PubMedCrossRefGoogle Scholar
  8. 8.
    Bodner J, Wykypiel H, Greiner A, Kirchmayr W, Freund MC, Margreiter R, Schmid T (2004) Early experience with robot-assisted surgery for mediastinal masses. Ann Thorac Surg 78(1):259–265PubMedCrossRefGoogle Scholar
  9. 9.
    Savitt MA, Gao G, Furnary AP, Swanson J, Gately HL, Handy JR (2005) Application of robotic-assisted techniques to the surgical evaluation and treatment of the anterior mediastinum. Ann Thorac Surg 79(2):450–455 (discussion 455)PubMedCrossRefGoogle Scholar
  10. 10.
    Augustin F, Schmid T, Bodner J (2006) The robotic approach for mediastinal lesions. Int J Med Robot 2(3):262–270PubMedCrossRefGoogle Scholar
  11. 11.
    Rea F, Marulli G, Bortolotti L, Feltracco P, Zuin A, Sartori F (2006) Experience with the “da Vinci” robotic system for thymectomy in patients with myasthenia gravis: report of 33 cases. Ann Thorac Surg 81(2):455–459PubMedCrossRefGoogle Scholar
  12. 12.
    Cakar F, Werner P, Augustin F, Schmid T, Wolf-Magele A, Sieb M, Bodner J (2007) A comparison of outcomes after robotic open extended thymectomy for myasthenia gravis. Eur J Cardiothorac Surg 31(3):501–504PubMedCrossRefGoogle Scholar
  13. 13.
    Augustin F, Schmid T, Sieb M, Lucciarini P, Bodner J (2008) Video-assisted thoracoscopic surgery versus robotic-assisted thoracoscopic surgery thymectomy. Ann Thorac Surg 85(2):S768–S771PubMedCrossRefGoogle Scholar
  14. 14.
    Castle SL, Kernstine KH (2008) Robotic-assisted thymectomy. Semin Thorac Cardiovasc Surg 20(4):326–331PubMedCrossRefGoogle Scholar
  15. 15.
    Ruckert JC, Ismail M, Swierzy M, Sobel H, Rogalla P, Meisel A, Wernecke KD, Ruckert RI, Muller JM (2008) Thoracoscopic thymectomy with the da Vinci robotic system for myasthenia gravis. Ann N Y Acad Sci 1132:329–335PubMedCrossRefGoogle Scholar
  16. 16.
    Sonett JR, Jaretzki A 3rd (2008) Thymectomy for nonthymomatous myasthenia gravis: a critical analysis. Ann N Y Acad Sci 1132:315–328PubMedCrossRefGoogle Scholar
  17. 17.
    Fleck T, Fleck M, Muller M, Hager H, Klepetko W, Wolner E, Wisser W (2009) Extended videoscopic robotic thymectomy with the da Vinci telemanipulator for the treatment of myasthenia gravis: the Vienna experience. Interact Cardiovasc Thorac Surg 9(5):784–787PubMedCrossRefGoogle Scholar
  18. 18.
    Goldstein SD, Yang SC (2010) Assessment of robotic thymectomy using the Myasthenia Gravis Foundation of America Guidelines. Ann Thorac Surg 89(4):1080–1085 (discussion 1085–1086)PubMedCrossRefGoogle Scholar
  19. 19.
    Wagner AJ, Cortes RA, Strober J, Grethel EJ, Clifton MS, Harrison MR, Farmer DL, Nobuhara KK, Lee H (2006) Long-term follow-up after thymectomy for myasthenia gravis: thoracoscopic vs open. J Pediatr Surg 41(1):50–54 (discussion 54)PubMedCrossRefGoogle Scholar
  20. 20.
    Toker A, Eroglu O, Ziyade S, Tanju S, Senturk M, Dilege S, Kalayci G (2005) Comparison of early postoperative results of thymectomy: partial sternotomy vs videothoracoscopy. Thorac Cardiovasc Surg 53(2):110–113PubMedCrossRefGoogle Scholar
  21. 21.
    Park A, Lee G, Seagull FJ, Meenaghan N, Dexter D (2010) Patients benefit while surgeons suffer: an impending epidemic. J Am Coll Surg 210(3):306–313PubMedCrossRefGoogle Scholar
  22. 22.
    Sivarajah M, Weksler B (2010) Robotic-assisted resection of a thymoma after two previous sternotomies. Ann Thorac Surg 90(2):668–670PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Benny Weksler
    • 1
  • Jonathan Tavares
    • 2
  • Timothy E. Newhook
    • 2
  • Christopher E. Greenleaf
    • 2
  • James T. Diehl
    • 3
  1. 1.University of Pittsburgh Medical CenterPittsburghUSA
  2. 2.Thomas Jefferson Medical CollegePhiladelphiaUSA
  3. 3.Thomas Jefferson University HospitalPhiladelphiaUSA

Personalised recommendations