Surgical Endoscopy

, Volume 24, Issue 8, pp 2056–2067

Minimally invasive fetoscopic interventions: an overview in 2010

Open Access
New Technology



The availability of high-end endoscopic equipment, microcatheters, miniballoons, tiny laser fibers, and other devices has been instrumental in the development of minimally invasive fetoscopic interventions. These interventions are performed for a spectrum of fetal disease states that progress in severity over the course of gestation and have a huge impact on termination of pregnancy rates, fetal demise, perinatal mortality and morbidity, and long-term prognosis. This report aims to introduce interested readers to these new procedures.


Fetoscopic interventions such as laser coagulation of pathologic placental vascular connections in twin-to-twin-transfusion-syndrome, fetal biopsies, fetal tracheal balloon occlusion in diaphragmatic hernia, perforation of posterior urethral valves, tracheal decompression in fetal laryngeal atresia, and even coverage of spina bifida aperta can be performed by percutaneous minimally invasive fetoscopic techniques.


In contrast to prenatally untreated patients, the majority of patients who underwent fetoscopic interventions followed by state-of-the-art neonatal intensive care experienced improved survival rates and enhanced quality of life. Yet for some patients, significant morbidity from the underlying disease or fetal surgical complications, most often early preterm delivery, persist in postnatal life.


A growing spectrum of fetal disease states has become amenable to minimally invasive fetoscopic interventions. Sufficient training, an interdisciplinary approach, ethical board supervision, and continued scientific assessment of benefits and risks are important for the success and acceptance of these procedures. Further improvements in fetal selection, surgical techniques, and postnatal management accompanied by the development of specialized devices are desired.


Amniotic band constriction Diaphragmatic hernia Fetal surgery Fetoscopy Minimally invasive Posterior urethral valves Prenatal medicine syndrome Spina bifida Twin-to-twin transfusion 

Fetal surgery aims to improve the poor prognoses of human fetuses affected by a spectrum of disease states that progress in severity over the course of gestation and have a huge impact on termination of pregnancy rates, fetal demise, perinatal mortality and morbidity, and long-term prognosis.

Lacking minimally invasive tools at the time, Michael Harrison and other investigators introduced open fetal surgery requiring maternal laparotomy and hysterotomy in the early 1980s [1]. Until today, the open fetal surgical approach is performed for some fetal surgical procedures, most commonly fetal spina bifida repair [2]. To reduce the maternal trauma from the open fetal surgical approach, minimally invasive fetoscopic procedures are being developed.

After fetoscopy first became available in about 1970, its clinical role for many years remained mostly confined to diagnostic purposes because image quality, particularly the lack of video cameras, put a lid on the development of more complex orchestrated procedures [3]. Since then, the availability of high-end endoscopic equipment as well as microcatheters, miniballoons, tiny laser fibers, and other devices has prompted the systematic development of minimally invasive fetoscopic interventions by a small number of teams around the world. As a consequence, fetoscopic procedures have become feasible [4, 5, 6, 7, 8, 9, 10], as have laser coagulation of pathologic placental vascular connections in twin–twin transfusion syndrome, fetoscopic umbilical cord ligation to prevent neurologic injury or demise in discordant monochorionic twins or twin-reversed arterial perfusion (TRAP), fetal tracheal balloon occlusion in diaphragmatic hernia, fulgurization of posterior urethral valves, tracheal decompression in fetal laryngeal atresia, and even coverage of spina bifida aperta over the past one and a half decades.

Maternal and fetal pain management monitoring and tocolysis

Infiltration of the maternal abdominal and uterine wall with local anesthetics provides sufficient maternal analgesia during most single-trocar fetoscopic procedures such as laser ablation of placental vessels or fetal tracheal balloon occlusion. Intraumbilical or direct fetal intramuscular administration of opioid analgesics and muscle relaxants suffices for most invasive procedures performed on the fetus. Only lengthy and complex procedures such as fetoscopic surgery for fetal spina bifida require general materno-fetal anesthesia. Standardized protocols ensure both patient safety and technical success [11, 12].

In contrast to previous assumptions, tocolytic requirements usually are minimal during the perioperative period of most minimally invasive fetal interventions. Either no tocolysis at all or only a one-time administration of either indomethacin or nifedipin, sometimes accompanied by infusion of the oxytocin antagonist atosiban, is used at our center. Notably, in monochorionic twin gestations affected by the twin-to-twin transfusion syndrome, indomethacin may prompt dangerous degrees of ductus arteriosus constriction [13].

Patients requiring more intense tocolysis usually are the ones who exhibit marked polyhydramnios resulting in uterine contractions, abdominal pain, cervical shortening, vaginal bleeding, and even increased C-reactive protein levels before fetal intervention. Therefore, not surprisingly, a massive polyhydramnios before fetal surgery accompanied by the aforementioned signs and symptoms has been the most important risk factor for perioperatively adverse outcomes at our center.

Maternal and fetal safety

In contrast to open fetal surgery, the minimally invasive fetoscopic approaches largely decrease maternal and fetal morbidity. Nevertheless, despite the use of small-caliber trocars, bleeding complications from vascular or placental injuries, separation of chorioamniotic membranes, amniotic fluid leakage, chorioamnionitis, or early preterm delivery must be expected to occur for some patients. Nevertheless, the majority of fetuses undergoing fetoscopic interventions, including those undergoing spina bifida repair via three trocars, currently are born beyond 32 weeks of gestation. At this gestational age, the risks from immaturity become so low that the benefits of the prenatal intervention may outweigh its risks.

Intraamniotic access

Currently, most fetoscopic interventions can be performed entirely by a percutaneous approach. Percutaneous intraamniotic access is facilitated by satisfactory ultrasound image quality, a not too obese maternal abdominal wall, and a favorable placenta position [14, 15, 16]. Depending on the operative goal, one to three trocars are placed into the amniotic cavity (Fig. 1). External trocar diameters usually range from 3 to 5 mm.
Fig. 1

Typical operating room setup for fetoscopic surgery at the author’s center. In this case, fetoscopic closure of fetal spina bifida was performed, requiring a three-trocar approach

Partial amniotic carbon dioxide insufflation

During complex fetoscopic surgical interventions, such as those for spina bifida aperta that require tissue dissection and resection, the amniotic fluid continuously gets tainted by small amounts of blood. In this setting, only partial insufflation of the amniotic cavity is needed to maintain adequate visualization throughout the entire procedure (Fig. 2).
Fig. 2

During complex fetoscopic surgical interventions such as those for spina bifida aperta, only partial amniotic carbon dioxide insufflation (PACI) can maintain adequate visualization throughout the entire procedure. Top: Close-up view of instrument manipulations using a 3.7-mm 30º fetoscope via three trocars with an external diameter of 5 mm. Bottom left: Superior visibility offered by PACI during dissection of the neural placode using a specially developed microknife. Bottom right: After removal of pathologic tissues, the neural tissue is covered by an absorbable patch

Both technical and safety aspects of amniotic gas insufflation have been examined in sheep and humans, with conflicting safety results [15, 17, 18, 19, 20, 21, 22, 23]. Some investigators observed that in this species, carbon dioxide insufflation may result in fetal acidosis and demise. In contrast, our group did not show detrimental effects of amniotic gas insufflation with either compressed air or carbon dioxide on the postnatal neurologic status, behavior, or brain histology of sheep during fetoscopic interventions. Based on our personal experience from these experiments, carbon dioxide has become the insufflation medium of first choice at our center.

At the time of this report, we had safely used partial amniotic carbon dioxide insufflation (PACI) during 51 human fetoscopic surgical procedures, for which efforts at obtaining sufficient visualization would have been too time consuming or impossible with conventional means [24]. Nevertheless, because of this still very limited clinical experience with PACI, continued assessment of its risks, safety margins, and management issues accompanied by serial postnatal patient follow-up evaluation using standardized development tests is desired.

Fetoscopic interventions

Diagnostic fetoscopy

The simplest fetoscopic procedures are diagnostic fetoscopies. For example, a fetal muscle or skin biopsy can be performed to rule out Duchenne muscular dystrophy or Harlekin ichthyosis. These procedures usually are well tolerated by the patient under maternal local anesthesia and fetal analgo-sedation. At many centers, less invasive ultrasound-guided biopsies have entirely replaced the fetoscopic approach.

Fetoscopic laser coagulation in the treatment of twin–twin transfusion syndrome

Severe twin–twin transfusion syndrome (TTTS) occurs in about 10% of monochorionic twin gestations. Untreated, the disease commonly results in the demise of both fetuses [25]. Because monochorionic twins share a single placenta, the circulation of one of the twins, the so-called “donor,” becomes compromised by blood and pressure loss via arteriovenous anastomoses toward its sibling twin, the so-called “recipient.” Additional venovenous or arterioarterial anastomoses that modify the disease course and severity also can be observed [26, 27].

On the other hand, the transfer of renin released by both the hypotensive, hypovolemic donor and the placenta favor the development of hypervolemia, hypertension, polyuria, cardiac failure, and abnormal fetoplacental blood flow in the recipient twin [28, 29]. Fetoscopic laser photocoagulation of abnormal placental vessels in TTTS has been developed and clinically introduced by de Lia et al. [4, 30] (Fig. 3). With some modifications as to where the pathologic vessels should be targeted on the placental surface [31], this approach has become the most commonly performed and tested fetoscopic procedure worldwide.
Fig. 3

Fetoscopic laser photocoagulation of abnormal placental vessels in twin–twin transfusion syndrome. The percutaneous procedure is performed with the patient under local anesthesia via a single trocar or after direct insertion of the fetoscope shaft. Most often, laser ablation of pathologic vessels on the placental surface is performed within amniotic fluid (top). For cases in which adequate visualization of an anterior placenta within blood-stained or turbid amniotic fluid is difficult, partial amniotic carbon dioxide insufflation (PACI) is used at the author’s center (bottom)

The results of a randomized trial by the Eurofetus group have proved that fetoscopic laser ablation is superior to serial amnioreduction in improving outcome [32]. In short, after fetoscopic laser ablation, the survival of at least one twin can be expected in about 80% of cases and the survival of both twins in about half of cases. Most fetuses currently are born beyond 30 weeks of gestation, and the incidence of neurologic damage in survivors is low. Preoperative staging of affected fetuses is most commonly performed by a system developed by Quintero et al. [33].

Based on a recent metaanalysis, fetoscopic laser ablation may now be considered for treating all stages of TTTS [34], yet further research investigating the effect of this treatment on milder stages is recommended. The procedure is performed with the patient under local anesthesia via a single trocar or after direct insertion of the fetoscope shaft using a stab trocar. For cases in which adequate visualization of an anterior placenta within blood-stained or turbid amniotic fluid is difficult, PACI is used at our center [35]. At the end of the procedure, excess amniotic fluid is drained, resulting in immediate improvement of maternal discomfort.

Fetoscopic laser ablation of posterior urethral valves

Total bladder outlet obstruction by posterior urethral valves before 20 weeks of gestation usually results in bilateral kidney destruction and due to the concomitant lack of amniotic fluid in severe pulmonary hypoplasia [36]. Prenatal intervention for this condition currently is most often performed by ultrasound-guided percutaneous shunt insertion for bladder drainage. Limited evidence from a systematic review and metaananalysis suggests that this approach may improve perinatal survival for affected fetuses, particularly those with poor predicted prognoses [37]. The University of Birmingham’s PLUTO (percutaneous shunting in lower urinary tract obstruction) trial aims to provide more robust evidence by conducting a prospective randomized multicenter investigation with a subgroup of affected fetuses [38].

As an alternative to vesico-amniotic shunt insertion, Quintero et al. [8] were the first to demonstrate the feasibility of therapeutic fetal cystoscopy and endoscopic fulguration of posterior urethral valves. Since then, posterior valve ablation has been performed by various groups for a larger number of patients, albeit with limited success [39, 40, 41]. Within the same anatomic region, endoscopic fetal urethrotomy for anterior urethral valves also has been described [42]. Recent technical modifications aim to facilitate fetoscopic bladder entry and overcome access to the proximal urethra from physiologic angulation of the bladder neck [43].

Unfortunately, ultrasound examination and serial analysis of fetal urine samples before fetal intervention remain unreliable for differentiating between groups of fetuses that may or may not benefit from fetal intervention [44, 45, 46, 47]. Therefore, further research is needed to improve fetal selection for intervention and to perform it earlier in the gestation period.

Fetoscopic lysis of amniotic bands

Amniotic bands constricting a fetal limb or the umbilical cord may result in loss of extremity function or fetal demise [48, 49]. After studies with fetal sheep demonstrating the potential for functional recovery of affected extremities after debanding [50], Quintero et al. [51] performed the first fetoscopic lysis of amniotic bands in human fetuses. Since then, the procedure has been performed for small numbers of human fetuses with variable success [52] (Fig. 4).
Fig. 4

Amniotic bands constricting a fetal limb or the umbilical cord may result in loss of extremity function or fetal demise. Top left: Three-dimensional ultrasound image exhibiting severe constriction of the distal third of the left calf in an unborn fetus at 21 + 1 weeks of gestation. Top right: Fetoscopic view during transection and removal of the band in the gas-insufflated amniotic cavity. Bottom left: Fetoscopic aspect after removal of the band. Pink skin coloration distal to the obstruction site allows assumption of preserved microvascular blood flow. Bottom right: After delivery, near normal contour and function of the left foot were observed. (Color figure online)

From our own limited experience with three fetuses, we assume that Doppler ultrasound demonstration of both arterial and venous wave forms accompanied by active muscle movements distal to the constriction indicate fetuses with limb constriction that may benefit from band removal [53].

Fetoscopic tracheal balloon occlusion in fetuses with diaphragmatic hernia

Herniation of abdominal organs into the fetal chest results in life-threatening pulmonary hypoplasia for about half of prenatally detected fetuses with congenital diaphragmatic hernia. Attempts at open fetal surgery to close the diaphragmatic defect during gestation did not improve survival for the most severely affected fetuses and impaired outcome in the less severe cases [54]. Alternatively, the therapeutic concept of fetoscopic tracheal occlusion was developed and introduced clinically [55, 56].

After tracheal occlusion, the pressure buildup from fluid normally released by the lung to maintain airway patency and promote pulmonary development throughout gestation results in lung distension and hyperplasia. Quintero et al. [7] were the first to report percutaneous single-trocar fetoscopic tracheal occlusion in a human fetus. Since then, the technique has been refined further in animal studies [57, 58, 59]. Like other single-trocar techniques, percutaneous fetoscopic tracheal balloon occlusion can be performed using maternal local anesthesia combined with fetal analgo-sedation and relaxation (Fig. 5). Fetal selection is based on ultrasound assessment of liver position, the so-called lung-to-head ratio, and/or determination of fetal lung volume by magnetic resonance imaging [60, 61, 62].
Fig. 5

Fetoscopic images during fetoscopic tracheal occlusion in a late gestation fetus with severe diaphragmatic hernia. Fetoscopic view using a 2-mm rod-lens endoscope in the fetal trachea before (top) and after (bottom) balloon insertion

For awhile, the results of a National Institutes of Health (NIH)-sponsored prospective randomized clinical trial carried out at the University of California at San Francisco (UCSF) stirred confusion about the value of the described approach [63]. The trial was prematurely abandoned when fetal tracheal occlusion had not improved outcome compared with postnatal intensive care therapy offered in this highly specialized center. Although obvious to the specialist reader, most readers seemed to miss that the study cohort included a marked proportion of less severely affected fetuses and that early preterm premature delivery also may have had an impact on the poor outcome in the occlusion group.

Following an effective international recruitment strategy, the Eurofetus consortium recently published their sobering experience with fetoscopic tracheal balloon occlusion in 210 cases with severe diaphragmatic hernia [64]. In these fetuses, the group achieved survival rates of 49% for severely affected fetuses with left and 35% of fetuses with right diaphragmatic hernia. Hinting to severe logistical problems at the time of delivery, 10 deaths alone could be directly attributed to difficulties with balloon removal. In addition, following tracheal occlusion at a mean gestational age of 27.1 weeks, 30% of cases where born prior to 34 weeks. At this gestational age, poor outcomes can be expected due to the more immature lungs and because extracorporeal membrane oxygenation is usually not an option.

Whereas Harrison et al. [63] already had speculated from their trial that early preterm delivery after fetoscopic tracheal occlusion might offset the beneficial effects of the intervention on pulmonary growth and function, further debate concerning the timing and duration of the occlusion period ensued between the European groups [65, 66]. Based on the UCSF and the Eurofetus experience and the ever growing body of experimental studies on fetal tracheal occlusion, our group introduced the strategy of deliberately delayed fetoscopic tracheal balloon occlusion [67]. The first goal of this strategy was to prevent entirely iatrogenic preterm delivery of immature fetuses with diaphragmatic hernia by postponing the intervention to beyond 30 weeks of gestation. The second goal was to achieve a gestational age at delivery that enabled these frail infants to be provided all means of intensive care therapy, particularly extracorporeal membrane oxygenation (ECMO). In addition, we reduced the occlusion period before removal of the balloon again by fetoscopy to between 8 and 14 days. Yet after application of our deliberately delayed and much shorter fetoscopic tracheal occlusion approach in sixteen fetuses with isolated left diaphragmatic hernia, only six (37%) survived to discharge. Adding to the frustration, one death resulted from anesthetic problems and three from balloons dislodging within the first three days of treatment. In these cases, two mothers opted against reintervention and one for termination of pregnancy. Our recent efforts in order to improve outcome in this subset of fetuses have resulted in the development of a more reliable occlusion device and in further postponing occlusion such that treated fetuses are born even nearer to term.

As neither in the similar sized control group nor in the failing-balloon group a single fetus with left diaphragmatic hernia has survived despite the postnatal availability of ECMO, I believe that the poor survival also reflects the selection of severest cases. In contrast, we observed an impressive survival rate in a small series of fetuses with right diaphragmatic hernia undergoing temporary tracheal occlusion at our center. Seven of eight fetuses (87%) with isolated right diaphragmatic hernia survived postnatal treatment to discharge. We attribute the markedly higher survival rates following the delayed approach in right diaphragmatic hernia to delivery of treated fetuses between 35 and 38 weeks of gestation, the regular availability of extracorporeal membrane oxygenation (ECMO) on the first day of life and despite smaller lungs to begin with the intrinsic property of more normally developed pulmonary vessels that vasodilate during materno-fetal hyperoxygenation in the right-sided condition.

In the meantime, the deliberately delayed and shortened approach to fetoscopic tracheal balloon occlusion has also been adopted for a current randomized trial protocol by Eurofetus, with the balloon placed at 30–32 + 6 weeks of gestation and removed at 34–35 + 6 weeks of gestation [68]. In our own randomized trial, we assess the value of the delayed approach in relation to a variety of postnatal treatment aspects for fetuses with less severe left diaphragmatic hernia [69]. Despite the availability of similar data previously published by Eurofetus for much larger cohorts of fetuses [70], an unblinded, nonrandomized trial by the pioneering fetal treatment center at UCSF simply focuses on fetal lung growth after successful tracheal occlusion by serial ultrasound assessment of the lung-to-head ratio [71].

Fetoscopic tracheal occlusion in fetuses with severe pulmonary hypoplasia from early preterm premature rupture of membranes

Early preterm premature rupture of membranes (ePPROM) before 22 weeks of gestation affects thousands of pregnant women throughout the world each year. Amniotic fluid loss often is so severe that anhydramnios occurs. It is in these cases that chronic external compression of the fetal chest from the uterine wall and marked upward displacement of the diaphragm by the liver interfere with normal lung development. Pulmonary hypoplasia may become so severe that chances of postnatal survival are poor [72].

Based on an analysis of 31 fetuses, Laudy et al. [73] calculated a positive predictive value of 86% for the development of lethal pulmonary hypoplasia when preterm premature rupture of membranes occurred at or before 20 weeks of gestation followed by 8 weeks or more of oligohydramnios and the degree of oligohydramnios was 1 cm or less.

Experimental treatments such as the amniopatch procedure or serial amnioinfusions have been ineffective in restoring adequate amounts of amniotic fluid in many pregnancies with spontaneously occurring ePPROM [74, 75, 76]. Therefore, based on the observation from ovine studies that experimental fetal tracheal ligation prevents pulmonary hypoplasia associated with fetal nephrectomy [77], we performed percutaneous fetoscopic tracheal balloon occlusion between 27 + 6 and 28 + 3 weeks of gestation in three fetuses with severe fetal pulmonary compression/hypoplasia from ePPROM [78, 79]. In each case, tracheal occlusion resulted in stunningly fast improvements in lung volume and survival.

Fetoscopic surgery for fetal laryngeal atresia

Near total to total occlusion of the fetal larynx or trachea is rarely observed. In about half of fetuses, this malformation occurs in association with Fraser syndrome [80]. Concomitant congestion of pulmonary fluid inside the fetal tracheobronchial tree causes massive distension and hyperplasia of the lungs as well as cardiac failure. For this sequence of events, the telling acronym CHAOS (congenital high-airway obstruction syndrome) has been coined. For affected hydropic fetuses, CHAOS has been almost uniformly fatal, yet some have been salvaged by elective preterm delivery using the ex utero intrapartum (EXIT) procedure [81, 82].

In fetal sheep with iatrogenic CHAOS, prenatal opening of the airway obstruction led to reversal of hydropic changes [83]. Based on these findings and the poor natural history of the syndrome, we performed percutaneous fetoscopic tracheal decompression in two hydropic human fetuses with laryngeal atresia and CHAOS at about 20 weeks of gestation (Fig. 6) [9, 84]. Fetal cardiac filling, diaphragmatic function, lung hyperechogenicity, and the cardiothoracic area ratio progressively normalized as a result of the percutaneous fetoscopic intervention. Both infants survived to discharge from the hospital.
Fig. 6

Sonographic and fetoscopic findings in a human fetus with congenital high-airway obstruction syndrome (CHAOS) from laryngeal atresia at 21 + 3 weeks of gestation. Top left: Fetal ultrasound imaging in the four-chamber view depicts the typical findings of bilateral lung hyperechogenicity and enlargement as well as a small heart. Top right: Five days after fetoscopic tracheal decompression, improvement in fetal heart–lung size relationship and normalization of lung echogenicity can be observed. Bottom left: Fetal laryngoscopy using a 2-mm 0° rod-lens fetoscope confirms laryngeal atresia by a membrane seen beneath the vocal folds. Bottom right: To achieve fetal tracheal decompression, a laser fiber was advanced via the working channel of the fetoscope and placed above the atretic region. At this location, the fiber was activated and repositioned until four small 0.4-mm openings were achieved

Fetoscopic spina bifida repair

Fetal surgery on unborns with spina bifida aims to protect the exposed neural tissue from amniotic fluid, fetal stool, and mechanical stress and to reduce hindbrain herniation [85, 86]. After studies with sheep, the first fetoscopic approaches for spina bifida closure in humans by maternal laparotomy, uterine exteriorization, and transuterine trocar placement were reported in the United States by Bruner et al. and Farmer et al. [23, 87, 88, 89]. Yet both teams abandoned their fetoscopic approaches because early results were disappointing due to technical difficulties.

Since then, fetoscopic fetal surgery for spina bifida has been replaced by an open surgical approach performed currently for several hundreds of human fetuses in North America [89, 90] and also for some fetuses in Brazil, Poland, and Spain. Pending the results of a randomized trial (MOMS trial), the therapeutic potential of the open operation to improve leg, bladder, and bowel function and to reduce the severity of hindbrain malformation and hydrocephalus will remain controversially discussed [91, 92, 93, 94, 95, 96, 97, 98, 99, 100].

To minimize maternal trauma from the open fetal surgical approach, after technical feasibility studies with inanimate models and sheep, our group reintroduced a percutaneous minimally invasive fetoscopic approach [10, 101]. Currently, the approach allows precise dissection of the placode, resection of pathologic tissues, and coverage of the malformation in layers such that neonatal neurosurgical repair currently has been obviated in already 10 cases (Fig. 2) [102, 103].

Probably because of more careful attention to membrane closure at the time of trocar removal than in earlier patients [104], most surgically treated fetuses currently are delivered at 32–35 weeks of gestation. From our early clinical experience in 25 human fetuses it appears that
  1. 1.

    the quality of leg function (and also likely bladder and bowel function), present at the time of surgery can be preserved in these fetuses, regardless of lesion height,

  2. 2.

    the fetoscopic procedure reliably results in improvements of hindbrain herniation, and

  3. 3.

    progressive ventricular dilatation and postnatal ventriculo-peritoneal shunt insertion can be avoided in most cases when the lateral ventricular width is ≤ 12 mm at the time of surgery.


Fetal cardiac interventions assisted by fetoscopy

Fetal cardiac interventions are being developed to improve the outcome and prognosis of fetuses with a spectrum of cardiac malformations, most often severe semilunar valve obstructions [110]. During fetal balloon valvuloplasty, we found that fetoscopic fetal transesophageal echocardiography (FFTEE) permits substantially clearer definition of fetal cardiac anatomy and intracardiac device manipulation than conventional maternal transabdominal fetal echocardiography (Fig. 7) [105, 106, 107, 108].
Fig. 7

Fetoscopic fetal transesophageal echocardiography (FFTEE) at 26 + 6 weeks of gestation in a human fetus with a closed atrial septum and aortic atresia. Top: Ultrasound catheter insertion requiring a single trocar. Middle: The closed atrial septum and the hypoplastic aortic root can be identified clearly (LA, left atrium; RA, right atrium). Bottom: A microinstrument with opened jaw (arrow) can be seen directed against the septum. Such clear demonstration of an intracardiac interventional device usually is not possible with the conventional imaging approach

Most recently, fetoscopic transesophageal electrocardiography has become available a minimally invasive tool for cardiac monitoring, diagnostics and intervention in human fetuses with theray refractory fetal tachycardias [109].

Less invasive alternatives to other fetoscopic procedures

Fetoscopic procedures such as umbilical cord ligation (Fig. 8) in discordant monochorionic twins or in the twin-reversed arterial perfusion (TRAP) sequence will most likely be replaced by technically far more simple and less invasive percutaneous ultrasound guided radiofrequency ablation of the umbilical vessels [110].
Fig. 8

Fetoscopic umbilical cord ligation in a discordant monochorionic twin pregnancy via a single trocar. Top: External aspect during knot pushing. Bottom: Clear demonstration of umbilical cord, ligature, and knot pusher during cord ligation in the gas insufflated amniotic cavity


For an increasing spectrum of fetal malformations and disease states, minimally invasive fetoscopic techniques can now be offered. Nevertheless, because these procedures still rely heavily on equipment borrowed from other specialties, further development of specialized instrumentation and devices is required. Their efficacy for improving fetal outcome over that demonstrated by state-of-the-art postnatal treatment strategies requires further studies in dedicated centers.


This report is cordially dedicated to Kristina Tchatcheva, who has over the past 5 years so often supported me with her infatigable camera skills during the most difficult fetoscopic prodedures. I thank the German Research Society (DFG) for funding my efforts to develop techniques for minimally invasive fetoscopic intervention by a whole series of grants since 1993.


Thomas Kohl is a consultant for Karl Storz Inc., Tuttlingen, Germany.

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Copyright information

© The Author(s) 2010

Authors and Affiliations

  1. 1.German Center for Fetal Surgery and Minimally Invasive Therapy, Department of Obstetrics and Prenatal MedicineUniversity of BonnBonnGermany

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