Surgical Endoscopy

, Volume 22, Issue 6, pp 1435–1439 | Cite as

Prospective randomized comparison of laparoscopic versus open adrenalectomy for sporadic pheochromocytoma

  • Guido A. M. Tiberio
  • Gian Luca Baiocchi
  • Luca Arru
  • Claudia Agabiti Rosei
  • Simona De Ponti
  • Albert Matheis
  • Damiano Rizzoni
  • Stefano M. Giulini



Laparoscopic adrenalectomy for pheochromocytoma remains subject of debate, owing to the systemic consequences of pneumoperitoneum in patients with catecholamine-secreting tumors.


A prospective randomized study was conducted (2000–2006), evaluating cardiovascular instability during open (n = 9, group A) or laparoscopic (n = 13, group B) adrenalectomy for pheochromocytoma. Haemodynamic parameters were recorded by invasive monitoring.


Haemodynamic instability was observed in 3/9 (group A) and 6/13 patients (group B), with a mean of 1.8 and 2.2 hypertensive peaks per patient (p = n.s.). Blood loss (164 ± 94 cc versus 48 ± 36 cc, p < 0.05) and operative time (180 ± 40 versus 158 ± 45 min, p = n.s.) favored laparoscopic procedures. Postoperative morbidity and mortality were nil. Hospital stay was shorter in group B (p < 0.05). Long-term follow-up was always normal.


Laparoscopic approach for pheochromocytoma can be as safe as open surgery; intraoperative haemodynamic instability, although usually controlled with success, remains a source of concern.


Pheochromocytoma Adrenalectomy Laparoscopy Open surgery 



The authors are very grateful to Prof. Bruno Mario Cesana of the Department of Biomedical Sciences and Biotechnology, Section of Medical Statistic, Brescia University for his valuable help in reviewing the statistical analysis of the paper.


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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Guido A. M. Tiberio
    • 1
    • 2
    • 3
  • Gian Luca Baiocchi
    • 1
  • Luca Arru
    • 1
  • Claudia Agabiti Rosei
    • 4
  • Simona De Ponti
    • 1
  • Albert Matheis
    • 5
  • Damiano Rizzoni
    • 4
  • Stefano M. Giulini
    • 1
  1. 1.Surgical Clinic, Department of Medical and Surgical SciencesUniversity of BresciaBresciaItaly
  2. 2.Campus Bio-Medico UniversityRomeItaly
  3. 3.BresciaItaly
  4. 4.Internal Medicine, Department of Medical and Surgical SciencesUniversity of BresciaBresciaItaly
  5. 5.Department of Anaesthesia and ResuscitationUniversity of BresciaBresciaItaly

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