Neuromonitoring and video-assisted thyroidectomy: a prospective, randomized case-control evaluation
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This study evaluates the role of intraoperative neuromonitoring (IONM) in video-assisted thyroidectomy (VAT) with emphasis given to the identification of recurrent laryngeal nerve (RLN) and external branch of superior laryngeal nerve (EBSLN).
The study was based on a prospectively randomized series comprising 72 standard VAT gasless approaches. In the control group (N = 36), the laryngeal nerves were identified by 30° 5-mm endoscope magnification solely. The standard technique of the IONM group (N = 36) consisted of localizing and monitoring EBSLN, both vagus and RLNs, before and after thyroid resection to prove nerve integrity. Surgical outcomes were mean operative time, nerve representation, incision length, and morbidity.
All procedures were performed successfully. There were no instances of equipment malfunction or interference. No permanent complications occurred in either group. The incidences of temporary RLN injury were 2.7% (1 patient) and 8.3% (3 patients) in the IONM and control group, respectively. The EBSLN was identified better in the IONM group: 83.6% versus 42% (p < 0.05). In the IONM group, a negative electromyography (EMG) response indicated an altered function of RLN and stage thyroidectomy was scheduled.
This is the first VAT series with a standardized IONM technique. The technical feasibility and safety of IONM in selected patients seem acceptable. Neuromonitoring during VAT is effective in providing identification and function of laryngeal nerves. IONM enables surgeons to feel more comfortable with their approach to VAT. A reduction of rates for postoperative complications could not be demonstrated in the present study. Larger series are needed for further evaluation.
KeywordsVideo-assisted thyroidectomy Morbidity Neuromonitoring Recurrent laryngeal nerve External branch of the superior laryngeal nerve Stage thyroidectomy
Written consent from the patients was obtained for publication of this report. Supported in part by grants from the Italian Ministry of Education, University and Research (FAR, Project 2007 “Il sistema di monitoraggio del nervo laringeo ricorrente e della branca sterna del nervo laringeo superior durante interventi di tiroidectomia mininvasiva”). The authors are grateful to Professors H. Dralle, G.W. Randolph, and L. Bartalena for general support, excellent technical assistance, and helpful discussion.
GD: acquisition of data; FR, LB: study conception and design; GD: analysis and interpretation of data; LB, BA: drafting of manuscript; RD: Critical revision and supervision.
- 8.Timmermann W, Hamelmann WH, Thomusch O, Sekulla C, Grond S, Neumann HJ, Kruse E, Mühlig HP, Richter C, Voss J, Dralle H (2004) Effectiveness and results of intraoperative neuromonitoring in thyroid surgery. Statement of the Interdisciplinary Study Group on Intraoperative Neuromonitoring of Thyroid Surgery. Chirurg 75(9):916–922Google Scholar
- 14.Dralle H, Sekulla C, Lorenz K, Brauckhoff M, Machens A, the German IONM Study Group (2008) Intraoperative monitoring of the recurrent laryngeal nerve in thyroid surgery. World J Surg [ahead of print]Google Scholar
- 16.Dionigi G, Rovera F, Boni L, Castano P, Dionigi R (2006) Surgical site infections after thyroidectomy. Surg Infect (Larchmt) 7:S117–S120Google Scholar
- 17.Miccoli P, Minuto MN, Ugolini C, Pisano R, Fosso A, Berti P (2008) Minimally invasive video-assisted thyroidectomy for benign thyroid disease: an evidence-based review. World J Surg [ahead of print]Google Scholar
- 18.Alvarado R, McMullen T, Sidhu SB, Delbridge LW, Sywak MS (2008) Minimally invasive thyroid surgery for single nodules: an evidence-based review of the lateral mini-incision technique. World J Surg [ahead of print]Google Scholar