Surgical Endoscopy

, Volume 22, Issue 2, pp 534–538 | Cite as

Comparison of four energy-based vascular sealing and cutting instruments: A porcine model

  • Benjamin PersonEmail author
  • David A. Vivas
  • Dan Ruiz
  • Michael Talcott
  • James E. Coad
  • Steven D. Wexner



To compare the safety and efficacy of four energy-based vascular sealing and cutting instruments.


Blood vessels of various types and diameters were harvested from four pigs using four instruments: Harmonic ACE™ (Ethicon Endo-Surgery, Cincinnati, OH), LigaSure™ V and LigaSure Atlas™ (Valleylab, Inc., Boulder, CO; a division of Tyco Healthcare), and EnSeal™ vessel fusion system (SurgRx, Inc. Redwood City, CA). The diameters of the vessels, speed and adequacy of the cutting and sealing process, and bursting pressures were compared. An additional set of specimens was sealed and left in situ for up to 4 h after which the vessels were harvested and histopathologically analyzed for the degree of thermal injury.


The bursting pressures were significantly higher with EnSeal™ compared to all other instruments (p < 0.0001). The sealing process was significantly shorter with Harmonic ACE™ and significantly longer with LigaSure Atlas™ (p <0.0001). The mean seal width was larger with the LigaSure Atlas™ compared to the other instruments, and it was smaller with EnSeal™ and Harmonic ACE™. Less radial adventitial collagen denaturation was present with EnSeal™ and LigaSure™ V than with the other two instruments; there were no significant differences in collagen denaturation although proximal thermal injury to the smooth muscle in the media of the vessel wall was less common with LigaSure Atlas™ than with the other instruments; however, the numbers were too small for statistical analysis.


The bursting pressures with EnSeal™ were significantly higher than with all the other instruments. Harmonic ACE™ was the fastest sealing instrument and LigaSure Atlas™ was slowest. EnSeal™ created less radial thermal damage to the adventitial collagen of the vessels and LigaSure Atlas™ created less thermal damage to the media of the vessels. The clinical significance of these findings is unknown.


Vascular sealing Energy-based Bursting pressure Thermal injury Porcine model 



–Research grant provided by SurgRx Inc., Redwood City, California

–SurgRx Inc. provides educational grant support to the Department of Colorectal Surgery at Cleveland Clinic Florida

–Ethicon Endosurgery Inc. provides educational grant support to the Department of Colorectal Surgery at Cleveland Clinic Florida

–Ethicon Endosurgery Inc., SurgRx Inc., and Tyco Healthcare Inc. provide financial support for Cleveland Clinic Florida educational programs

–Dr. Talcott is a consultant and owns stock at SurgRx Inc.


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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Benjamin Person
    • 1
    Email author
  • David A. Vivas
    • 1
  • Dan Ruiz
    • 1
  • Michael Talcott
    • 2
  • James E. Coad
    • 3
  • Steven D. Wexner
    • 1
  1. 1.Department of Colorectal SurgeryCleveland ClinicWestonUSA
  2. 2.Division of Comparative MedicineWashington University, St. Louis School of MedicineWashingtonUSA
  3. 3.Department of PathologyRobert C. Byrd Health Sciences Center of West Virginia UniversityPAUSA

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