The effect of a low-carbohydrate diet on the nonalcoholic fatty liver in morbidly obese patients before bariatric surgery
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Bariatric surgery may be complicated by enlargement of the liver, especially of the left lobe, caused by nonalcoholic fatty liver disease often present with morbid obesity.
The effect of a very low carbohydrate diet for 4 weeks before surgery on liver density and volume was assessed in 14 candidates for bariatric surgery. Computed tomography (CT) scans were performed before and at termination of the diet period.
The CT scans clearly showed a significant increase in mean liver density (p = 0.06) and a decrease in mean liver volume (p = 0.01). The increased mean density of the left lobe was markedly greater than that of the right lobe.
The findings show that 4 weeks of a very low carbohydrate diet reduces liver fat content and liver size, particularly of the left lobe. This approach may render bariatric surgery or any foregut operations less difficult in morbidly obese patients and may be a useful treatment for nonalcoholic fatty liver disease.
KeywordsBariatric surgery Low-carbohydrate diet Nonalcoholic fatty liver
- 12.Nakamuta M, Morizono S, Soejima Y, Yoshizumi T, Aishima S, Takasugi S, Yoshimitsu K, Enjoji M, Kotoh K, Taketomi A, Uchiyama H, Shimada M, Nawata H, Maehara Y (2005) Short-term intensive treatment for donors with hepatic steatosis in living-donor liver transplantation. Transplantation 80: 608–612PubMedCrossRefGoogle Scholar
- 16.Posulka PS, Bistrain BR, Benotti PN, Blackburn GL (1986) The risks of surgery in obese patients. Ann Intern Med 104: 540–546Google Scholar
- 17.Schwartz JM, Linfoot P, Dare D, Aghajanian K (2003) Hepatic de novo lipogenesis in normoinsulinemic and hyperinsulinemic subjects consuming high fat, low-carbohydrate and low-fat, high-carbohydrate isoenergenic diets. Am J Clin Nutr 77:43–50Google Scholar
- 18.Sjostorm CD, Lissner L, Wedel H, Sjostorm L (1999) Reduction in incidence of diabetes, hypertension, and lipid disturbance after intentional weight loss induced by bariatric surgery: the SOS intervention study. Obes Res 7: 477–484Google Scholar