Pneumoperitoneum does not influence trocar site implantation during tumor manipulation in a solid tumor model
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- Halpin, V.J., Underwood, R.A., Ye, D. et al. Surg Endosc (2005) 19: 1636. doi:10.1007/s00464-005-0005-0
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The purpose of this study was to assess tumor implantation at abdominal wound sites following manipulation of a solid abdominal tumor.
GW-39 human colon cancer cells were injected into the omentum of golden Syrian hamsters. At 2 weeks, an omental tumor was harvested and animals were randomized to bivalve (A), crush (B), strip (C), or excision (D), with or without pneumoperitoneum. Four 5-mm trocars were inserted into the abdomen, and the tumor was reinserted through the midline, swept through four quadrants, and removed. The incision was closed and pneumoperitoneum at 7 mmHg was maintained for 10 min. Tumor implantation at wound sites was documented at 7 weeks.
Implantation at trocar sites was 53 and 49% with and without pneumoperitoneum in the manipulated groups (A, B, C), respectively (p = 0.993). Implantation at trocar sites was reduced in the control group (D) at 9 and 10% with and without pneumoperitoneum, respectively (p < 0.001).
Tumor implantation at trocar sites is due to spillage of tumor during manipulation and not to pneumoperitoneum.