Surgical Endoscopy And Other Interventional Techniques

, Volume 16, Issue 9, pp 1297–1301 | Cite as

Role of dopamine in renal dysfunction during laparoscopic surgery

  • J. Pérez
  • P. Taurá
  • J. Rueda
  • J. Balust
  • T. Anglada
  • J. Beltran
  • A. M. Lacy
  • J. C. Garcia-Valdecasas
Original Articles



Sympathetic vascular insult and hemodynamic changes represent the most reliable explanation of renal impairment resulting from acute intraabdominal pressure. We evaluated the effects of low-dose dopamine administration during a long-lasting surgical laparoscopic procedure.


For this study 40, patients submitted to a colorectal laparoscopic procedure with 15 mmHg of intraabdominal pressure were randomly allocated to two groups: 20 receiving 2μg/kg/min of dopamine and 20 receiving the same perfusion of saline. Hemodynamic parameters, renal function, urinary output, and creatinine clearance, were studied.


The hemodynamic parameters were similar in both groups. The urinary output decreased during the intraoperative period only the saline group (p=0.4). Then 2 h postoperatively, it increased in both groups, and no statistically significant differences were found between the groups. The creatinine clearance decreased in both groups during the intraoperative time, but it was worse in the saline group (−28±120 vs −194±106; p=0.022). During the postoperative period, both groups showed improvement, but in control group the values remained lower than at baseline (p=0.04), and significantly lower than in the dopamine group (230±337 vs 100±192; p=0.012).


An intrabdominal pressure of 15 mmHg induces a time-limited renal dysfunction, and low doses of dopamine could prevent this undesirable effect.

Key words

Laparoscopic surgery Renal impairment Dopamine Protective effect 


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Copyright information

© Springer-Verlag 2002

Authors and Affiliations

  • J. Pérez
    • 1
  • P. Taurá
    • 1
  • J. Rueda
    • 1
  • J. Balust
    • 1
  • T. Anglada
    • 1
  • J. Beltran
    • 1
  • A. M. Lacy
    • 2
  • J. C. Garcia-Valdecasas
    • 2
  1. 1.Anesthesiology Department, Hospital Clinic of BarcelonaUniversity of BarcelonaBarcelonaSpain
  2. 2.Digestive Surgery Department, Hospital Clinic of BarcelonaUniversity of BarcelonaBarcelonaSpain

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