Surgical Endoscopy And Other Interventional Techniques

, Volume 16, Issue 9, pp 1336–1340

A new method of preemptive analgesia in laparoscopic cholecystectomy

  • U. Maestroni
  • D. Sortini
  • C. Devito
  • F. Pour Morad Kohan Brunaldi
  • G. Anania
  • L. Pavanelli
  • A. Pasqualucci
  • A. Donini
Original Articles

DOI: 10.1007/s00464-001-9181-8

Cite this article as:
Maestroni, U., Sortini, D., Devito, C. et al. Surg Endosc (2002) 16: 1336. doi:10.1007/s00464-001-9181-8

Abstract

Background

Although laparoscopic cholecystectomy (LC) results in less pain then open cholecystectomy, it is not a pain-free procedure. The aim of this study was to test a new method of preemptive analgesia.

Methods

By simple randomization 60 patients were assigned to two groups (30 in each group). Group A, the placebo group, received 200 ml of 0.9% saline, and group B received 5 mg/kg of a local anesthetic solution (ropivacaine) in 200 ml of 0.9% saline. Local anesthetic or place solution were administer before creation of the pneumoperitoneum.

Results

Pain intensity, as rated by visual analog and verbal rating scales, and stress response data were significantly less in the group receiving ropivacaine than in the placebo group. No patients in treatment group received an additional dose of analgesic, whereas two patients in placebo group needed an additional analgesic.

Conclusions

Our results support the clinical validity of preemptive analgesia, but the timing of intraperitoneal administration of local anesthetic is very important. Only application before creation of the pneumoperitoneum may preempt every neuronal central sensitization.

Key words

Laparoscopic cholecistectomy Postoperative pain Preemptive analgesia 

Copyright information

© Springer-Verlag 2002

Authors and Affiliations

  • U. Maestroni
    • 1
  • D. Sortini
    • 1
  • C. Devito
    • 1
  • F. Pour Morad Kohan Brunaldi
    • 2
  • G. Anania
    • 1
  • L. Pavanelli
    • 1
  • A. Pasqualucci
    • 1
  • A. Donini
    • 1
  1. 1.Department of Surgery, Anaesthsiology, and RadiologyUniversity of FerraraFerraraItaly
  2. 2.Department of Biomedical SciencesUniversity of FerraraFerraraItaly

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