COLOR

A randomized clinical trial comparing laparoscopic and open resection for colon cancer
  • The Color Study Group
  • E. J. Hazebroek
Original Articles

Abstract

Background

Laparoscopic surgery has proven to be safe and effective. However, the value of laparoscopic resection for malignancy in terms of cancer outcome can only be assessed by large prospective randomized clinical trials with sufficient follow-up.

Methods

COLOR (COlon carcinoma Laparoscopic or Open Resection) is a European multicenter randomized trial that began in 1997. In 27 hospitals in Sweden, The Netherlands, Germany, France, Italy, Spain, and the United Kingdom, 1200 patients will be included. The primary endpoint of the study is cancer-free survival after 3 years.

Results

In <3.5 years, >850 patients have been randomized for right hemicolectomy (47%), left hemicolectomy (11%), and sigmoidectomy (42%). Fifty seven patients were excluded after randomization. Forty six months after the start of the trial, the overall recurrence rate is 6.8%. The distribution of stage of disease is as follows: stage I, 25%; stage II, 41%; stage III, 32%; stage IV, 2%.

Conclusion

Although laparoscopic surgery appears to be of value in the treatment of colorectal cancer, the final, results of randomized trials need to be considered to determine its definitive role. Given the current accrual rate, the COLOR study will be completed in 2002.

Key words

Laparoscopy Colorectal cancer Multicenter randomized trial Cancer 

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Copyright information

© Springer-Verlag 2002

Authors and Affiliations

  • The Color Study Group
  • E. J. Hazebroek
    • 1
  1. 1.Department of SurgeryUniversity Hospital Rotterdam-DijkzigtRotterdamThe Netherlands

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