, Volume 32, Issue 3, pp 449–453 | Cite as

Effect of Food Thickener on the Inhibitory Effect of Mitiglinide Tablets on Post-prandial Elevation of Blood Glucose Levels

  • Takashi TomitaEmail author
  • Hidekazu Goto
  • Kenji Sumiya
  • Tadashi Yoshida
  • Katsuya Tanaka
  • Kenzo Kudo
  • Yukinao Kohda
Original Article


The aim of this study was to examine the effect of food thickener on the pharmacodynamics of mitiglinide (MGN), a drug belonging to a class of rapid-acting insulin secretagogues. First, MGN tablets were coated by immersion in a xanthan gum-based food-thickening agent. This treatment was shown to delay disintegration rates of MGN tablets in vitro. The pharmacodynamics of MGN after ingestion of a single oral dose of an MGN tablet, with or without food thickener immersion, were then examined in an open-label crossover study comprising 5 healthy participants. It was observed that after administration of 75 g of oral glucose, the area under the blood glucose concentration–time curve was larger for treatment with MGN tablets that had been immersed in the food thickener than for nonimmersed tablets. The maximum blood glucose level was also higher in treatments with MGN tablets that had been immersed in food thickener. The extended time of higher glucose levels associated with thickener-immersed MGN tablets given to human volunteers may be associated with the reduced disintegration rates of immersed MGN tablets as observed in the in vitro experiment. Overall, our study suggests that commercially available food thickeners influence the pharmacodynamics of MGN and that their use should therefore be carefully assessed and monitored in certain clinical situations.


Food thickener Deglutition Mitiglinide Deglutition disorders Post-prandial elevation Blood glucose level 


Compliance with Ethical Standards

Conflict of interest

The authors declare no conflict of interest.


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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • Takashi Tomita
    • 1
    • 2
    Email author
  • Hidekazu Goto
    • 2
  • Kenji Sumiya
    • 3
  • Tadashi Yoshida
    • 4
  • Katsuya Tanaka
    • 5
  • Kenzo Kudo
    • 1
  • Yukinao Kohda
    • 2
    • 6
  1. 1.Department of Clinical Pharmaceutics and Pharmacy Practice, School of PharmacyIwate Medical UniversityMoriokaJapan
  2. 2.Department of PharmacyHospital BandoBandoJapan
  3. 3.Faculty of PharmacyIwaki Meisei UniversityIwakiJapan
  4. 4.Department of Internal MedicineHospital BandoBandoJapan
  5. 5.Department of PsychiatryHospital BandoBandoJapan
  6. 6.Faculty of Health SciencesTsukuba International UniversityTsuchiuraJapan

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