Risperidone-Induced Bulbar Palsy-like Syndrome
- 385 Downloads
There have been several case reports of risperidone-associated dysphagia. Risperidone-induced bulbar palsy-like syndrome has not been previously described. We report on a 58-year-old gentleman with prior history of schizophrenia and remote chlorpromazine use with no history of extrapyramidal symptoms who experienced acute onset of dysphagia and facial diplegia with hyperprolactinemia while being treated with risperidone. To date there have been five reported cases of dysphagia associated with risperidone, occurring by such mechanisms as isolated pharyngeal dysfunction from pharyngeal constrictor palsy and dystonia, drug-induced parkinsonism, and acute dystonic reaction. These cases were associated either with initiation or up-titration of risperidone, with complete resolution of dysphagia after medication discontinuation or dose change. Our patient developed dysphagia within 2 weeks of taking risperidone and completely resolved 1 month after the medication was stopped. Unlike other reported cases, our patient also experienced symptomatic hyperprolactinemia, another known side effect of risperidone. Physicians should also be aware that risperidone can be associated with oropharyngeal dysphagia secondary to an acute bulbar palsy-like syndrome that places patients at increased risk of aspiration events and its associated morbidity and mortality.
KeywordsDysphagia Oropharyngeal hypomotility Deglutition Deglutition disorders Bulbar palsy Risperidone Hyperprolactinemia Swallowing
- 3.Janssen Pharmaceutica, Risperdal package insert. Available at http://www.janssen.com/janssen/products.html. Accessed 10 Nov 2008.
- 8.Nair S, Saeed O, Shahab H. Sudden dysphagia with uvular enlargement following the initiation of risperidone which responded to benztropine: was this an extrapyramidal side effect? Gen Hosp Psychiatry 2001;23:231-2.Google Scholar
- 12.Buchholz D. Neurogenic dysphagia: what is the cause when the cause is not obvious? Dysphagia 2004;9:245-55.Google Scholar