Comparison of fumaric acid production by Rhizopus oryzae using different neutralizing agents
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Fumaric acid fermentation in a 10-L bubble column fermenter using different neutralizing agents [CaCO3, Ca(OH)2, NaHCO3] by Rhizopus oryzae ATCC 20344 was examined. It was found that in the fermentation using CaCO3 as the neutralizing agent the highest fumaric acid weight yield and volumetric productivity were obtained, 53.4% and 1.03 g/L×h–1 respectively. In the NaHCO3 case, the fumaric acid weight yield and volumetric productivity were 33.7% and 0.69 g/L×h–1, respectively, much lower than the CaCO3 case. However, the NaHCO3 alternative has advantages of cell reuse and simple downstream processing because of the high solubility of sodium fumarate. These advantages may offset the disadvantages of using NaHCO3 as the neutralizing agent, and the overall fumaric acid weight yield and volumetric productivity will increase.
KeywordsSodium Fermentation CaCO3 NaHCO3 Acid Production
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