Bioprocess Engineering

, Volume 18, Issue 3, pp 191–199

The performance of a scaled down industrial disc stack centrifuge with a reduced feed material requirement

  • J. P. Maybury
  • K. Mannweiler
  • N. J. Titchener-Hooker
  • M. Hoare
  • P. Dunnill
Article

DOI: 10.1007/s004490050430

Cite this article as:
Maybury, J., Mannweiler, K., Titchener-Hooker, N. et al. Bioprocess Engineering (1998) 18: 191. doi:10.1007/s004490050430

Abstract

A method is described for the scale-down of a disc stack centrifuge which reduces the number of separating discs and also the liquid and solid hold-up of the centrifuge bowl. This is to enable a reduced volume of process material to be used for study of clarification. Scale-down is achieved in stages using a series of interlocking inserts to suit particular applications. Maximum scale-down gives a 76% reduction in the separation area and a bowl volume reduction of 70%. Separation performance of the full stack machine and scale-down variants is compared using the grade efficiency concept. Polyvinyl acetate and bakers' yeast homogenate particle suspensions are used for the comparison. The grade efficiency curves produced by the scale-down variants closely follow the curves for the full stack machine. This resulted in supernatants of the same volume size distribution and concentration when using scale-down methodology to mimic the full scale operation.

Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • J. P. Maybury
    • 1
  • K. Mannweiler
    • 1
  • N. J. Titchener-Hooker
    • 1
  • M. Hoare
    • 1
  • P. Dunnill
    • 1
  1. 1.The Advanced Centre for Biochemical Engineering, Department of Chemical and Biochemical Engineering, University College London, Torrington Place, London WC1E 7JE, UKGB

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