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Bioengineered gold nanoparticles from marine seaweed Acanthophora spicifera for pharmaceutical uses: antioxidant, antibacterial, and anticancer activities

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Abstract

In this study, we report a green synthesis of pharmaceutically active gold nanoparticles from marine red alga Acanthophora spicifera by the reduction of chloroauric acid. The formation of A. spicifera-mediated gold nanoparticles (As-AuNPs) was characterized by several analytical techniques. The crystalline and face-centered cubic (fcc) structure were confirmed by X-ray diffraction (XRD) analysis. Electron microscopy results confirmed that As-AuNPs were spherical and the average size of particles was < 20 nm. As-AuNPs hold a significant level of antioxidant activities than A. spicifera extract. As-AuNPs exhibited the highest antibacterial activity against Vibrio harveyi than Staphylococcus aureus at 100 µg/ml. Furthermore, As-AuNPs exhibited the utmost cytotoxicity against human colon adenocarcinoma (HT-29) cells and registered the half-maximal inhibitory concentration (IC50) at 21.86 µg/ml. These findings authenticated that the synthesized As-AuNPs possess a broad spectrum of biological activities, and it can be effectively applied in the field of aquaculture and biomedical application.

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Acknowledgements

The authors are grateful to RUSA scheme Phase 2.0 Grant [F-24-51/ 2014–U, Policy (TNMulti-Gen), Dept of Edn. Govt. of India. Dt. 09.10.2018] for their financial support. The authors also wish to thank the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2018R1A6A1A03023584) for the support to complete this work.

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Authors and Affiliations

  1. Disease Control and Prevention Lab, Department of Animal Health and Management, Alagappa University, Karaikudi, Tamil Nadu, 630 003, India

    Baskaran Babu, Manoharan Vinosha, Ravichandran Anjali & Narayanasamy Marimuthu Prabhu

  2. East Coast Life Sciences Institute, Gangneung-Wonju National University, 120 Gangneung, Gangwon, 210-720, Republic of Korea

    Subramanian Palanisamy & SangGuan You

  3. Department of Marine Food Science and Technology, Gangneung-Wonju National University, 120 Gangneungdaehangno, Gangneung, Gangwon, 210-702, Republic of Korea

    Subramanian Palanisamy & SangGuan You

  4. Food Chemistry and Molecular Cancer Biology Lab, Department of Animal Health and Management, Alagappa University, Karaikudi, Tamil Nadu, 630 003, India

    Ponnuchamy Kumar

  5. Department of Bioinformatics, Alagappa University, Karaikudi, Tamil Nadu, 630 003, India

    Boomi Pandi

  6. Department of Seafood Processing, Faculty of Marine Sciences, Tarbiat Modares University, P.O. Box 46414-356, Noor, Iran

    Mehdi Tabarsa

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  1. Baskaran Babu
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  9. Narayanasamy Marimuthu Prabhu
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Correspondence to Narayanasamy Marimuthu Prabhu.

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There are no conflicts to declare. Also, I hereby declare that Dr. Mehdi Tabarsa, one of our manuscript co-authors, is an Associate Professor of the Department of Seafood Processing at Tarbiat Modares University which has no function other than research and education. Moreover, none of them is an official representative or on behalf of the government.

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Babu, B., Palanisamy, S., Vinosha, M. et al. Bioengineered gold nanoparticles from marine seaweed Acanthophora spicifera for pharmaceutical uses: antioxidant, antibacterial, and anticancer activities. Bioprocess Biosyst Eng 43, 2231–2242 (2020). https://doi.org/10.1007/s00449-020-02408-3

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