Bioprocess and Biosystems Engineering

, Volume 38, Issue 6, pp 1167–1177 | Cite as

Extracellular synthesis of gold bionanoparticles by Nocardiopsis sp. and evaluation of its antimicrobial, antioxidant and cytotoxic activities

  • Panchanathan Manivasagan
  • Moch Syaiful Alam
  • Kyong-Hwa Kang
  • Minseok Kwak
  • Se-Kwon KimEmail author
Original Paper


Advancement of biological process for the synthesis of bionanoparticles is evolving into a key area of research in nanotechnology. The present study deals with the biosynthesis, characterization of gold bionanoparticles by Nocardiopsis sp. MBRC-48 and evaluation of their antimicrobial, antioxidant and cytotoxic activities. The gold bionanoparticles obtained were characterized by UV–visible spectroscopy, X-ray diffraction analysis, Fourier transform infrared spectroscopy, field emission scanning electron microscopy, energy dispersive X-ray analysis and transmission electron microscopy (TEM). The synthesized gold bionanoparticles were spherical in shape with an average of 11.57 ± 1.24 nm as determined by TEM and dynamic light scattering (DLS) particle size analyzer, respectively. The biosynthesized gold nanoparticles exhibited good antimicrobial activity against pathogenic microorganisms. It showed strong antioxidant activity as well as cytotoxicity against HeLa cervical cancer cell line. The present study demonstrated the potential use of the marine actinobacterial strain of Nocardiopsis sp. MBRC-48 as an important source for gold nanoparticles with improved biomedical applications including antimicrobial, antioxidant as well as cytotoxic agent.


Gold bionanoparticles Extracellular Marine actinobacteria Biosynthesis Antimicrobial Antioxidant Cytotoxicity 



This paper was supported by research funds of Pukyong National University in 2015.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Panchanathan Manivasagan
    • 1
  • Moch Syaiful Alam
    • 1
  • Kyong-Hwa Kang
    • 1
  • Minseok Kwak
    • 2
  • Se-Kwon Kim
    • 1
    Email author
  1. 1.Department of Marine-Bio Convergence Science and Marine Bioprocess Research CenterPukyong National UniversityBusanRepublic of Korea
  2. 2.Department of ChemistryPukyong National UniversityBusanRepublic of Korea

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