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Cell and Tissue Research

, Volume 301, Issue 1, pp 133–142 | Cite as

Radiation-induced apoptosis

  • Marcel Verheij
  • Harry Bartelink
Review

Abstract

Radiation-induced apoptosis has been a topic of intense research during the last decade. Its recognition as a significant component of radiation-induced cell death has initiated several lines of investigation aimed at modulating the apoptotic response and thereby radiosensitivity. These strategies require the integration of both classical radiobiological concepts and the knowledge of the biochemical and molecular biological mechanisms involved in apoptosis induction. This review discusses mechanisms of radiation-induced apoptosis and highlights the radiobiological and radiotherapeutical relevance of this mode of cell death.

Ionizing radiation Clonogenic survival Apoptosis Signal transduction p53 SAPK/JNK Caspases 

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Copyright information

© Springer-Verlag 2000

Authors and Affiliations

  • Marcel Verheij
    • 1
  • Harry Bartelink
    • 1
  1. 1.Department of Radiation OncologyThe Netherlands Cancer Institute/Antoni van Leeuwenhoek ZiekenhuisAmsterdamThe Netherlands

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