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Novel therapeutic approaches of tissue engineering in male infertility

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Male reproductive organ plays an important role in sperm production, maintenance and entry to the female reproductive tract, as well as generation and secretion of male sex hormones responsible for the health of male reproductive system. The purpose of this paper is to discuss the experimental and clinical evidence on the utilization of tissue engineering techniques in treating male infertility. Tissue engineering (TE) and regenerative medicine have developed new approaches to treat patients with reproductive disorders such as iatrogenic injuries, congenital abnormalities, and trauma. In some cases, including congenital defects and undescended testis or hypogonadism, the sperm samples are not retrieved. This makes TE a possible future strategy for restoration of male fertility. Here, we have summarized the recent advances in experimental and clinical application of cell-, tissue-, and organ-based regenerative medicine in male reproductive disorders.

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Tissue engineering


Extracellular matrix


induced pluripotent stem cells


Embryonic stem cells


Mesenchymal stem cells


Growth factors


Assisted reproductive techniques


Vascular endothelial growth factor


Bone morphogenetic protein


Transforming growth factor


Human embryonic stem cells


Spermatogonia stem cells






in vitro fertilization


Intracytoplasmic sperm injection


Somatic cell nuclear transfer


Primordial germ cells


Congenital bilateral vas deferens


Smooth muscle cells


Testis-derived scaffolds


Testicular organoids


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This study was supported by stem cell research center at Tabriz University of Medical Sciences, Iran.

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Correspondence to Mehdi Yousefi.

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Ghanbari, E., Khazaei, M., Ghahremani-nasab, M. et al. Novel therapeutic approaches of tissue engineering in male infertility. Cell Tissue Res (2020). https://doi.org/10.1007/s00441-020-03178-w

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  • Tissue engineering
  • Regenerative medicine
  • Stem cell
  • Growth factor
  • Scaffold