Cell and Tissue Research

, Volume 378, Issue 3, pp 531–542 | Cite as

Human orbital adipose tissue-derived mesenchymal stem cells possess neuroectodermal differentiation and repair ability

  • Darilang Mawrie
  • Kasturi Bhattacharjee
  • Amit Sharma
  • Renu Sharma
  • Jina Bhattacharyya
  • Harsha Bhattacharjee
  • Nilutparna Deori
  • Atul Kumar
  • Bithiah Grace JaganathanEmail author
Regular Article


Mesenchymal stem cells (MSCs) are used extensively in cell therapy for repair and regeneration of several organs and tissues. Cell therapy is a valuable option to treat neurodegenerative diseases and MSCs have been shown to improve neuronal function through direct differentiation or secretion of neurotrophic factors. In the present study, we isolated and characterized stem cells from medial and central orbital adipose tissue and found that they could be grown in a monolayer culture. The orbital adipose tissue-derived cells were identical to bone marrow-derived MSCs in their cell surface marker expression, gene expression and multilineage differentiation abilities. The orbital adipose-derived MSCs (OAMSCs) express several neurotrophic factors, possess neuroectodermal differentiation ability and secreted factors from OAMSCs abrogated neuronal cell damage induced by oxidative stress. Thus, OAMSCs might be a valuable cell source for treatment of neurological diseases and to reverse oxidative damage in the neuronal cells.


Stem cells Neuroprotection Cell therapy Neurodegenerative disease Oxidative damage 



DM, AS, RS and AK were supported by MHRD, Govt. of India.

Authors’ contributions

KB and BGJ conceived the study. DM, AK and BGJ designed the study. KB performed blepharoplasty surgery. DM, AS, RS and AK performed experiments. DM, KB, JB, HB, ND and BGJ analyzed the data. DM, KB and BGJ wrote the manuscript. All the authors approved the final version of the manuscript.

Funding information

This work was supported by funds from the Indian Institute of Technology Guwahati (IITG).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflicts of interest.

Ethical statement

All procedures involving human samples were in accordance with the Helsinki convention and approved by the ethics committee of the Indian Institute of Technology Guwahati and Sri Sankaradeva Nethralaya, Guwahati. The study was carried out in accordance with the human ethics committee guidelines and written informed consent was obtained from all the patients involved in the study.

Supplementary material

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Darilang Mawrie
    • 1
  • Kasturi Bhattacharjee
    • 2
  • Amit Sharma
    • 1
  • Renu Sharma
    • 1
  • Jina Bhattacharyya
    • 3
  • Harsha Bhattacharjee
    • 2
  • Nilutparna Deori
    • 2
  • Atul Kumar
    • 1
  • Bithiah Grace Jaganathan
    • 1
    Email author
  1. 1.Stem Cell and Cancer Biology Group, Department of Biosciences and BioengineeringIndian Institute of Technology GuwahatiGuwahatiIndia
  2. 2.Departmentof Oculoplastics, Aesthetics and Reconstructive Surgery, Sri Sankaradeva NethralayaGuwahatiIndia
  3. 3.Department of HematologyGauhati Medical College HospitalGuwahatiIndia

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