Cell and Tissue Research

, Volume 375, Issue 1, pp 217–225 | Cite as

Neuropeptides in sensory signal processing

  • Richard CarrEmail author
  • Stephan Frings
Mini Review


Peptides released from trigeminal fibers fulfill well-understood functions in neuroinflammatory processes and in the modulation of nociceptive signal processing. In particular, calcitonin gene-related peptide (CGRP) and substance P (SP), released from afferent nerve terminals, exert paracrine effects on the surrounding tissue and this has been recently highlighted by the prominent parcrine role of CGRP in the development of headache and migraine. Some recent communications suggest that these sensory neuropeptides may also modulate the workings of sensory organs and influence afferent signals from nose, tongue, eyes and ears. Here, we briefly review the evidence for modulatory effects of CGRP and SP in the sensory periphery.


Neuropeptide Sensory Trigeminal Chemesthesis CGRP 


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Experimental Pain Research, Medical Faculty MannheimUniversity of HeidelbergMannheimGermany
  2. 2.Department of Animal Physiology, Centre for Organismal StudiesUniversity of HeidelbergHeidelbergGermany

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