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Isolated aggregates of lymphoid cells in the inner bronchial wall in asthma patients

  • Thomas Tschernig
  • Reinhard Pabst
  • Frauke Prenzler
  • Susanne Rittinghausen
  • Armin Braun
  • Jens M. Hohlfeld
Short Communication

Abstract

Here, we report findings in volunteers with bronchial asthma. Biopsies were obtained from the inner bronchial wall before and a short time again after segmental allergen provocation. In most of the baseline biopsies and in all evaluable biopsies after segmental allergen provocation, the follicular lymphoid tissue was detected by immunohistochemistry in the epithelium of these asthmatic patients. The basic occurrence of the tertiary lymphoid tissue in the bronchial mucosa of mild asthmatics was unexpected and may have consequences for the interpretation of pathophysiology, e.g., as a cause or consequence of bronchial asthma.

Keywords

Bronchial asthma BALT Isolated aggregated lymphoid cells Tertiary lymphoid tissue Autoimmunity 

Notes

Acknowledgements

The skillful technical assistance of the staff members during the study conduct and sample preparation is gratefully acknowledged.

Author contributions

JH and AB conducted the study, JH did the bronchoscopies, FP and SR did the analyses and evaluations, and TT and RP wrote the manuscript.

Funding information

This work was partly funded by grants from the DFG (SFB587, GRK 1441) and the German Center for Lung Research.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Thomas Tschernig
    • 1
  • Reinhard Pabst
    • 2
  • Frauke Prenzler
    • 3
  • Susanne Rittinghausen
    • 3
  • Armin Braun
    • 2
    • 3
    • 4
    • 5
    • 6
  • Jens M. Hohlfeld
    • 3
    • 5
    • 7
  1. 1.Institute of Anatomy and Cell BiologySaarland UniversityHomburg/SaarGermany
  2. 2.Institute of ImmunomorphologyHannover Medical SchoolHannoverGermany
  3. 3.Fraunhofer Institute for Toxicology and Experimental MedicineHannoverGermany
  4. 4.Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH)HannoverGermany
  5. 5.Member of the German Centre for Lung Research (DZL)HannoverGermany
  6. 6.Member of the REBIRTH Cluster of ExcellenceHannoverGermany
  7. 7.Department of Respiratory MedicineHannover Medical SchoolHannoverGermany

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