MicroRNAs in the hypothalamic control of energy homeostasis
Obesity is a medical condition characterized by excess of fat content in the body. The majority of obese patients additionally develop cardiovascular disease and type 2 diabetes mellitus collectively referred to as the metabolic syndrome. Such condition reduces life expectancy and may ultimately result in cancer development. It affects more than half a billion adults worldwide and is a constantly growing epidemic, especially in developed and developing countries. This can be largely attributed to the lack of genetic, epigenetic, and social resistance to the unprecedented availability of cheap carbohydrate and fat rich food. Metabolic challenges such as over-eating or fasting transiently or chronically disrupt energy homeostasis which is maintained by a tightly regulated communication between peripheral organs and the central nervous system. In the former, the key regulatory functions are attributed to the pancreas, the main endocrine organ in the glucose metabolism, fat-storing cells...
This work was funded by the National Natural Science Foundation of China (31771433) and Shanghai Jiao Tong University (AF0800056) to I.A.V., and National Centre for Research and Development, Poland, 3/POLTUR-1/2016/APPETITE-MIR to W.K.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
This article does not contain any studies with mouse or human participants performed by any of the authors.
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