Cell and Tissue Research

, Volume 371, Issue 2, pp 223–236 | Cite as

Laminin-derived Ile-Lys-Val-ala-Val: a promising bioactive peptide in neural tissue engineering in traumatic brain injury

  • Sajad Sahab Negah
  • Alireza Khooei
  • Fariborz Samini
  • Ali Gorji


The adult brain has a very limited regeneration capacity and there is no effective treatment currently available for brain injury. Neuroprotective drugs aim to reduce the intensity of cell degeneration but do not trigger tissue regeneration. Cell replacement therapy is a novel strategy to overcome brain injury-induced disability. To enhance cell viability and neuronal differentiation, developing bioactive scaffolds combined with stem cells for transplantation is a crucial approach in brain tissue engineering. Cell interactions with the extracellular matrix (ECM) play a vital role in neuronal cell survival, neurite outgrowth, attachment, migration, differentiation, and proliferation. Thus, appropriate cell–ECM interactions are essential when designing and modifying scaffolds for application in neural tissue engineering. To improve cell–ECM interactions, scaffolds can be modified with bioactive peptides. Here, we discuss the characteristic features of laminin-derived Ile-Lys-Val-Ala-Val (IKVAV) sequence as a bio-functional motif in scaffolds and the behavior of stem cells in scaffolds conjugated with the IKVAV peptide. The incorporation of this bioactive peptide in nanofiber scaffolds markedly improves stem cell behavior and may be a potential method for cell replacement therapy in traumatic brain injury.


IKVAV peptide Cell therapy Brain injury Tissue engineering Stem cells 







Beta-amyloid precursor protein


Bone marrow mesenchymal stem cell


Central nervous system


Chondroitin sulfate proteoglycans


Dorsal root ganglion


Extracellular matrix


Embryonic stem cells


Gallium nitride


Human neural stem cells


Human umbilical cord mesenchymal stem cells




Integrin-linked kinase


Induced neural stem cells


Laminin-binding protein


Mitogen-activated protein kinase/extracellular signal-regulated kinase


Neural stem cells


Oligodendrocyte progenitor cells


2-hydroxyethyl methacrylate with 2-aminoethyl methacrylate


Polyethylene glycol


Phosphatidylinositol 3-kinase/protein kinase B


Lactide-co-ethylene oxide-co-fumarate






Self-assembling peptide


Self-assembly peptide nanofiber scaffold


Subcallosal zone


Subgranular zone




Traumatic brain injury


Ventricular–subventricular zone





This study was supported by the Iran National Science Foundation (INSF) to AG.

Compliance with ethical standards

Conflict of interest

There is no conflict of interest.


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Copyright information

© Springer-Verlag GmbH Germany 2017

Authors and Affiliations

  • Sajad Sahab Negah
    • 1
    • 2
  • Alireza Khooei
    • 3
  • Fariborz Samini
    • 4
  • Ali Gorji
    • 1
    • 2
    • 5
    • 6
  1. 1.Department of Neuroscience, Faculty of MedicineMashhad University of Medical SciencesMashhadIran
  2. 2.Shefa Neuroscience Research CenterKhatam Alanbia HospitalTehranIran
  3. 3.Department of Pathology, Faculty of MedicineMashhad University of Medical SciencesMashhadIran
  4. 4.Department of Neurosurgery, Faculty of MedicineMashhad University of Medical SciencesMashhadIran
  5. 5.Department of Neurology and Department of NeurosurgeryWestfälische Wilhelms-Universität MünsterMünsterGermany
  6. 6.Epilepsy Research CenterWestfälische Wilhelms-Universität MünsterMünsterGermany

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