Cell and Tissue Research

, Volume 367, Issue 3, pp 643–649 | Cite as

Pulmonary vascular remodeling in pulmonary hypertension

  • Rubin M. Tuder


Pulmonary vascular remodeling is the key structural alteration in pulmonary hypertension and involves changes in the intima, media and adventitia, often with the interplay of inflammatory cells. This review examines the pathology of these changes and highlights some of the pathogenetic mechanisms that underlie the remodeling process.


Pulmonary hypertension Pulmonary remodeling Endothelial cells Smooth muscle cells Lung 



The author’s work mentioned in this review was supported by grants R24 HL123767 and P01 HL014985-41A1.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  1. 1.Program in Translational Lung Research, Division of Pulmonary Sciences and Critical Care Medicine, Department of MedicineUniversity of Colorado School of MedicineAuroraUSA

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