Cell and Tissue Research

, Volume 362, Issue 2, pp 269–279 | Cite as

Understanding the effects of mature adipocytes and endothelial cells on fatty acid metabolism and vascular tone in physiological fatty tissue for vascularized adipose tissue engineering

  • Birgit Huber
  • Ann-Cathrin Volz
  • Petra J. KlugerEmail author


Engineering of large vascularized adipose tissue constructs is still a challenge for the treatment of extensive high-graded burns or the replacement of tissue after tumor removal. Communication between mature adipocytes and endothelial cells is important for homeostasis and the maintenance of adipose tissue mass but, to date, is mainly neglected in tissue engineering strategies. Thus, new co-culture strategies are needed to integrate adipocytes and endothelial cells successfully into a functional construct. This review focuses on the cross-talk of mature adipocytes and endothelial cells and considers their influence on fatty acid metabolism and vascular tone. In addition, the properties and challenges with regard to these two cell types for vascularized tissue engineering are highlighted.


Mature adipocytes Endothelial cells Co-culture Vascularized fatty tissue engineering Cross-talk 


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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Birgit Huber
    • 1
  • Ann-Cathrin Volz
    • 2
  • Petra J. Kluger
    • 2
    • 3
    Email author
  1. 1.Institute of Interfacial Process Engineering and Plasma TechnologyUniversity of StuttgartStuttgartGermany
  2. 2.Process Analysis & Technology (PA&T)Reutlingen UniversityReutlingenGermany
  3. 3.Fraunhofer Institute for Interfacial Engineering and Biotechnology IGBStuttgartGermany

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