Regulatory effect of chemokines in bone marrow niche
- 710 Downloads
Chemokines secreted from different cellular components of bone marrow (BM) play an important role in the formation of the BM niche system. The hematopoietic stem cell (HSC) pool located in specialized anatomical sites within the BM is subjected to a complex network of chemokines, such that the produced chemokines affect the fate of these cells. Expression of different chemokine receptors on leukemic stem cells (LSCs) uncovers the critical role of chemokines in the maintenance, survival and fate of these cells in the leukemic niche. As a pre-metastatic niche rich in a variety of chemokines, the BM niche is turned into a locus of tumor cell development and division. The chemokine receptors expressed on the surface of metastatic cells lead to their metastasis and homing to the BM niche. Knowledge of chemokines and their receptors leads to the production of various therapeutic antagonists at chemokine receptors expressed on leukemic and tumor cells, enabling interference with chemokine function as a therapeutic tool. New findings suggest that miRNAs, with their specific inhibitory function, affect the ability of producing and expressing chemokines and chemokine receptors. This review focuses on the emerging role of chemokines and their receptors in normal and pathologic conditions of the BM niche, and also discusses the new therapeutic methods with this background.
KeywordsChemokines Stem cell niche Hematopoietic stem cells Metastasis
We are grateful to all our colleagues in the Health Research Institute, Research Center of Thalassemia & Hemoglobinopathy.
Najmaldin Saki and Richard E. Kast conceived the manuscript and revised it; Neda Ketabchi, Mohammad Shahjahani and Ahmad Ahmadzadeh wrote the manuscript; Kaveh Jaseb and Saeid Shahrabi contributors helped writing final version of manuscript.
Conflict of interest
The authors declare no conflict of interest.
- Abroun S (2008) Chemokines in homeostasis and cancers. Yakhteh Med J 10:155–166Google Scholar
- Arabanian LS, Fierro FA, Stölzel F, Heder C, Poitz DM, Strasser RH, Wobus M, Bornhäuser M, Ferrer RA, Platzbecker U (2014) miRNA-23a mediates post-transcriptional regulation of CXCL12 in bone marrow stromal cells. Haematol Haematol 99:997–1005, 2013.097675Google Scholar
- Browne G, Taipaleenmäki H, Stein GS, Stein JL, Lian JB (2014) MicroRNAs in the control of metastatic bone disease. Trends Endocrinol Metab 25:6Google Scholar
- Bydlowski SP, Levy D, Ruiz JM, Pereira J (2013) Hematopoietic stem cell niche: role in normal and malignant hematopoiesis: In: Alimoghaddam K (ed) Stem cell biology in normal life and diseases, vol V.InTech, Rijeka, pp 17–32Google Scholar
- Clark EA, Kalomoiris S, Nolta JA, Fierro FA (2014) Concise review: MicroRNA function in multipotent mesenchymal stromal cells. Stem Cells 32:1074–1082Google Scholar
- Deng L, Chen N, Li Y, Zheng H, Lei Q (2010) CXCR6/CXCL16 functions as a regulator in metastasis and progression of cancer. Biochimica et Biophysica Acta (BBA)-reviews on. Cancer 1806:42–49Google Scholar
- Grassi F, Piacentini A, Cristino S, Toneguzzi S, Cavallo C, Facchini A, Lisignoli G (2003) Human osteoclasts express different CXC chemokines depending on cell culture substrate: molecular and immunocytochemical evidence of high levels of CXCL10 and CXCL12. Histochem Cell Biol 120:391–400PubMedGoogle Scholar
- Johnson EL, Singh S, Johnson-Holiday C, Singh UP, Partridge EE, Datta MW, Lillard JW (2006) CCL25-CCR9 axis role in ovarian cancer cell metastasis and survival. Proc Am Assoc Cancer Res 2006:70Google Scholar
- Karnoub AE, Weinberg RA (2007) Chemokine networks and breast cancer metastasis. Breast Dis 26:75–85Google Scholar
- Klarenbeek A, Maussang D, Blanchetot C, Saunders M, van der Woning S, Smit M, de Haard H, Hofman E (2013) Targeting chemokines and chemokine receptors with antibodies. Drug Discov Today Technol 9:e237–e244Google Scholar
- Krause DS, Scadden DT, Preffer FI (2013) The hematopoietic stem cell niche—home for friend and foe? Cytometry B 84:7–20Google Scholar
- Lisignoli G, Toneguzzi S, Piacentini A, Cattini L, Lenti A, Tschon M, Cristino S, Grassi F, Facchini A (2003) Human osteoblasts express functional CXC chemokine receptors 3 and 5: activation by their ligands, CXCL10 and CXCL13, significantly induces alkaline phosphatase and β‐N‐acetylhexosaminidase release. J Cell Physiol 194:71–79PubMedGoogle Scholar
- López-Giral S, Quintana NE, Cabrerizo M, Alfonso-Pérez M, Sala-Valdés M, de Soria VGG, Fernández-Rañada JM, Fernández-Ruiz E, Muñoz C (2004) Chemokine receptors that mediate B cell homing to secondary lymphoid tissues are highly expressed in B cell chronic lymphocytic leukemia and non-Hodgkin lymphomas with widespread nodular dissemination. J Leukoc Biol 76:462–471PubMedGoogle Scholar
- Nakamura ES, Koizumi K, Kobayashi M, Saitoh Y, Arita Y, Nakayama T, Sakurai H, Yoshie O, Saiki I (2006) RANKL-induced CCL22/macrophage-derived chemokine produced from osteoclasts potentially promotes the bone metastasis of lung cancer expressing its receptor CCR4. Clin Exp Metastasis 23:9–18PubMedGoogle Scholar
- Pontikoglou C, Deschaseaux F, Sensebé L, Papadaki HA (2011) Bone marrow mesenchymal stem cells: biological properties and their role in hematopoiesis and hematopoietic stem cell transplantation. Stem Cell Rev Rep 7:569–589Google Scholar
- Saki N, Abroun S, Hagh MF, Asgharei F (2011) Neoplastic bone marrow niche: hematopoietic and mesenchymal stem cells. Cell J (Yakhteh) 13:131Google Scholar
- Taubenberger AV (2014) In vitro microenvironments to study breast cancer bone colonisation. Adv Drug Deliv Rev 79-80C:135–144Google Scholar
- Tzoneva G, Ferrando AA (2012) Recent advances on NOTCH signaling in T-ALL. CurrTop Microbiol Immunol 360:163–182Google Scholar