Cell and Tissue Research

, Volume 356, Issue 3, pp 575–584 | Cite as

Roles of chromatin remodeling BAF complex in neural differentiation and reprogramming

Review

Abstract

ATP-dependent BAF chromatin remodeling complexes play an essential role in the maintenance of the gene expression program by regulating the structure of chromatin. There is increasing evidence that BAF complexes based on the alternative ATPase subunits, Brg1 and Brm, control the differentiation of neural stem cells (NSCs) to generate distinct neural cell types and modulate trans-differentiation between cell types. The BAF complexes have dedicated functions at different stages of neural differentiation that appear to arise by combinatorial assembly of their subunits. Furthermore, the differentiation of NSCs is regulated by the tight interactions between the BAF chromatin remodeling complex and the transcriptional machinery. Here, we review recent insights into the functional interaction between BAF complexes and various transcription factors (TFs) in neural differentiation and cellular reprogramming.

Keywords

BAF complex Chromatin regulation Neural stem cells Neural differentiation Reprogramming 

Notes

Acknowledgments

We apologize to colleagues whose work we may not have been able to include in this review due to space limitation. We thank J. Staiger for his support and M. Ahmad and K. Shanmugarajan for proofreading of the manuscript. This work was supported by the University Medicine Göttingen (UMG) and DFG grant (TU 432/1-1). The authors declare no competing financial interests

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Institute of NeuroanatomyUniversitätsmedizin GöttingenGöttingenGermany

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