Cell and Tissue Research

, Volume 349, Issue 3, pp 783–793 | Cite as

Delivering value from sperm proteomics for fertility

  • Aruna Govindaraju
  • Sule Dogan
  • Nelida Rodriguez-Osorio
  • Kamilah Grant
  • Abdullah Kaya
  • Erdogan MemiliEmail author


Fertilization of an egg by a spermatozoon sets the stage for mammalian development. Viable sperm are a prerequisite for successful fertilization and beyond. Spermatozoa have a unique cell structure where haploid genomic DNA is located in a tiny cytoplasmic space in the head, mitochondria in the midpiece and then the tail, all enclosed by several layers of membrane. Proteins in sperm play vital roles in motility, capacitation, fertilization, egg activation and embryo development. Molecular defects in these proteins are associated with low fertility or in some cases, infertility. This review will first summarize genesis, molecular anatomy and physiology of spermatozoa, fertilization, embryogenesis and then those proteins playing important roles in various aspects of sperm physiology.


Sperm Proteomics Fertility Markers Biotechnology 


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Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Aruna Govindaraju
    • 1
  • Sule Dogan
    • 1
  • Nelida Rodriguez-Osorio
    • 2
  • Kamilah Grant
    • 1
  • Abdullah Kaya
    • 3
  • Erdogan Memili
    • 1
    Email author
  1. 1.Department of Animal and Dairy SciencesMississippi State UniversityStarkvilleUSA
  2. 2.Grupo Centauro Universidad de AntioquiaMedellinColombia
  3. 3.Alta Genetics, Inc.WatertownUSA

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