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Cell and Tissue Research

, Volume 344, Issue 1, pp 1–11 | Cite as

Global daily dynamics of the pineal transcriptome

  • Diego M. Bustos
  • Michael J. Bailey
  • David Sugden
  • David A. Carter
  • Martin F. Rath
  • Morten Møller
  • Steven L. Coon
  • Joan L. Weller
  • David C. KleinEmail author
Mini Review

Abstract

Transcriptome profiling of the pineal gland has revealed night/day differences in the expression of a major fraction of the genes active in this tissue, with two-thirds of these being nocturnal increases. A set of over 600 transcripts exhibit two-fold to >100-fold daily differences in abundance. These changes appear to be primarily attributable to adrenergic-cyclic-AMP-dependent mechanisms, which are controlled via a neural pathway that includes the suprachiasmatic nucleus, the master circadian oscillator. In addition to melatonin synthesis, night/day differences in gene expression impact genes associated with several specialized functions, including the immune/inflammation response, photo-transduction, and thyroid hormone/retinoic acid biology. The following nonspecialized cellular features are also affected: adhesion, cell cycle/cell death, cytoskeleton, DNA modification, endothelium, growth, RNA modification, small molecule biology, transcription factors, vesicle biology, signaling involving Ca2+, cyclic nucleotides, phospholipids, mitogen-activated protein kinases, the Wnt signaling pathway, and protein phosphorylation.

Keywords

Pineal gland Suprachiasmatic nucleus Circadian rhythm Gene expression Transcriptome Microarray Systems biology 

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Copyright information

© Springer-Verlag (outside the USA) 2011

Authors and Affiliations

  • Diego M. Bustos
    • 1
  • Michael J. Bailey
    • 2
  • David Sugden
    • 3
  • David A. Carter
    • 4
  • Martin F. Rath
    • 5
  • Morten Møller
    • 5
  • Steven L. Coon
    • 6
  • Joan L. Weller
    • 6
  • David C. Klein
    • 6
    • 7
    Email author
  1. 1.Instituto Tecnológico de Chascomús (Instituto de Investigaciones Biotecnológicas-Instituto Tecnológico de Chascomús)ChascomúsArgentina
  2. 2.Department of Poultry ScienceTexas A & M UniversityCollege StationUSA
  3. 3.Division of Reproduction and Endocrinology, School of Biomedical and Health SciencesKing’s College LondonLondonUK
  4. 4.School of BiosciencesCardiff UniversityCardiffUK
  5. 5.Department of Neuroscience and Pharmacology, Faculty of Health SciencesUniversity of CopenhagenCopenhagenDenmark
  6. 6.Section on Neuroendocrinology, Program on Developmental Endocrinology and Genetics, The Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentNational Institutes of HealthBethesdaUSA
  7. 7.BethesdaUSA

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