Stress at the intestinal surface: catecholamines and mucosa–bacteria interactions
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Psychological stress has profound effects on gastrointestinal function, and investigations over the past few decades have examined the mechanisms by which neural and hormonal stress mediators act to modulate gut motility, epithelial barrier function and inflammatory states. With its cellular diversity and large commensal bacterial population, the intestinal mucosa and its overlying mucous environment constitute a highly interactive environment for eukaryotic host cells and prokaryotic bacteria. The elaboration of stress mediators, particularly norepinephrine, at this interface influences host cells engaged in mucosal protection and the bacteria which populate the mucosal surface and gut lumen. This review will address growing evidence that norepinephrine and, in some cases, other mediators of the adaptation to stress modulate mucosal interactions with enteric bacteria. Stress-mediated changes in this delicate interplay may shift the microbial colonization patterns on the mucosal surface and alter the susceptibility of the host to infection. Moreover, changes in host-microbe interactions in the digestive tract may also influence ongoing neural activity in stress-responsive brain areas.
KeywordsBacteria Autonomic nervous system Immune cells Nerves Gut-to-brain
This work was supported by grants from the National Institutes of Health to L.V. (DA-17236) and D.R.W. (DA-10200).
- Chiocchetti R, Mazzuoli G, Albanese V, Mazzoni M, Clavenzani P, Lalatta-Costerbosa G, Lucchi ML, Di Guardo G, Marruchella G, Furness JB (2008) Anatomical evidence for ileal Peyer's patches innervation by enteric nervous system: a potential route for prion neuroinvasion? Cell Tissue Res 332:185–194PubMedCrossRefGoogle Scholar
- Diard S, Liévin-Le Moal V, Toribio AL, Boum Y, Vigier F, Servin AL, Bouvet O (2009) Norepinephrine-dependently released Dr fimbriae of diffusely adhering Escherichia coli strain IH11128 promotes a mitogen-activated protein kinase ERK1/2-dependent production of pro-inflammatory cytokine, IL-8 in human intestinal Caco-2/TC7 cells. Microbes Infect 11:886–894PubMedCrossRefGoogle Scholar
- Lyte M (2010a) Microbial Endocrinology: A Personal Journey. In: Lyte M, Freestone PPE (eds) Microbial endocrinology: interkingdom signaling in infectious disease and health. Springer, New York, pp 1–16Google Scholar
- Lyte M, Freestone PPE (2010) Microbial endocrinology: interkingdom signaling infectious disease and health. Springer, New YorkGoogle Scholar
- Moss AC, Anton P, Savidge T, Newman P, Cheifetz AS, Gay J, Paraschos S, Winter MW, Moyer MP, Karalis K, Kokkotou E, Pothoulakis C (2007) Urocortin II mediates pro-inflammatory effects in human colonocytes via corticotropin-releasing hormone receptor 2alpha. Gut 56:1210–1217PubMedCrossRefGoogle Scholar
- Nijhuis LE, Olivier BJ, de Jonge WJ (2010) Neurogenic regulation of dendritic cells in the intestine. Biochem Pharmacol (in press)Google Scholar
- Ochoa-Cortes F, Ramos Lomas T, Miranda-Morales M, Spreadbury I, Ibeakanma C, Barajas-López C, Vanner SJ (2010) Bacterial cell products signal to mouse colonic nociceptive dorsal root ganglia neurons. Am J Physiol Gastrointest Liver Physiol (in press)Google Scholar
- Pullinger GD, Carnell SC, Sharaff FF, van Diemen PM, Dziva F, Morgan E, Lyte M, Freestone PP, Stevens MP (2010a) Norepinephrine augments Salmonella enterica-induced enteritis in a manner associated with increased net replication but independent of the putative adrenergic sensor kinases QseC and QseE. Infect Immun 78:372–380PubMedCrossRefGoogle Scholar
- Selye H (1978) The stress of life, 2nd edn. McGraw-Hill, New YorkGoogle Scholar
- Walker AK, Nakamura T, Hodgson DM (2010) Neonatal lipopolysaccharide exposure alters central cytokine responses to stress in adulthood in Wistar rats. Stress (in press)Google Scholar