Cell and Tissue Research

, Volume 343, Issue 1, pp 153–165

NF-κB and STAT3 signaling hubs for lung innate immunity

Review

Abstract

Innate immune responses to lung pathogens involve the coordinated expression of myriad affector and effector molecules of innate immunity, which must be induced and appropriately regulated in response to diverse stimuli generated by microbes or the infected host. Many intercellular and intracellular signaling pathways are involved, but we propose NF-κB and STAT3 transcription factors to be especially important signaling hubs for integrating these pathways to orchestrate effective host defense without excessive inflammatory injury.

Keywords

Pneumonia Innate immunity NF-ĸB STAT3 Transcriptional regulation 

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© Springer-Verlag 2010

Authors and Affiliations

  1. 1.The Pulmonary CenterBoston University School of MedicineBostonUSA

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