Cell and Tissue Research

, Volume 343, Issue 1, pp 97–106

Monocyte and macrophage heterogeneity and Toll-like receptors in the lung

  • David Schneberger
  • Karin Aharonson-Raz
  • Baljit Singh
Review

Abstract

Mononuclear phagocytes are crucial components of the innate host defense system. Cells such as macrophages and monocytes phagocytose and process pathogens, produce inflammatory mediators, and link the innate and the adaptive immune systems. The role of innate immune receptors such as Toll-like receptors (TLRs) in the recognition of pathogens is critical for mounting a precise and targeted immune response. This review focuses attention on the development of monocytes and macrophages, various populations of macrophages, and the expression and function of TLRs on macrophages.

Keywords

Lung Innate immunity Pulmonary intravascular macrophages Toll-like receptors Heterogeneity 

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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • David Schneberger
    • 1
  • Karin Aharonson-Raz
    • 2
  • Baljit Singh
    • 1
  1. 1.Department of Veterinary Biomedical SciencesUniversity of SaskatchewanSaskatoonCanada
  2. 2.Koret School of Veterinary MedicineThe Hebrew University of JerusalemJerusalemIsrael

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